Lung Cancer Mortality Trends in a Brazilian City with a Long History of Asbestos Consumption

Abstract

There are scarce epidemiological studies on lung cancer mortality in areas exposed to asbestos in developing countries. We compared the rates and trends in mortality from lung cancer between 1980 and 2016 in a municipality that made extensive use of asbestos, Osasco, with rates from a referent municipality with lower asbestos exposure and with the rates for the State of São Paulo. We retrieved death records for cases of lung cancer (ICD-9 C162) (ICD-10 C33 C34) from 1980 to 2016 in adults aged 60 years and older. The join point regression and age-period-cohort models were fitted to the data. Among men, there was an increasing trend in lung cancer mortality in Osasco of 0.7% (CI: 0.1; 1.3) in contrast to a mean annual decrease for Sorocaba of -1.5% (CI: −2.4; −0.6) and a stable average trend for São Paulo of -0.1 (IC: −0.3; 0.1). Similar increasing trends were seen in women. The age-period-cohort model showed an increase in the risk of death from 1996 in Osasco and a reduction for Sorocaba and São Paulo State during the same period. Our results point to a need for a special monitoring regarding lung cancer incidence and mortality in areas with higher asbestos exposure.

Causes of death in former asbestos‐cement workers in the state of São Paulo, Brazil

“…10 This finding is in agreement with the results of a Brazilian study showing considerable excess mortality from this condition in the city of Osasco compared to the entire country. 13 The excess mortality due to lung MN among the participants was similar to the findings in previous cohorts of asbestos-cement workers. 15,[28][29][30] Recently, an ecological analysis found an increasing trend in mortality due to lung cancer in the city of Osasco that was not seen in the state of São Paulo as a whole.…”

“…15,[28][29][30] Recently, an ecological analysis found an increasing trend in mortality due to lung cancer in the city of Osasco that was not seen in the state of São Paulo as a whole. 31 Mortality analyses are not sensitive for diseases with long survival durations, such as MN of the larynx, which has a 5-year survival rate of 72.3%. 32 The long survival time of patients with laryngeal MN may mean that these individuals die due to other causes.…”

“…From the 1970s onward, fiber use increased significantly, reaching a peak of 1.5-1.6 kg/inhabitant between 1985 and 1991. 13 In 2016, the country produced 20.4% of the total asbestos consumed worldwide. 14 Studies on mortality in workers exposed to asbestos have been carried out in recent decades in Italy, 10,15,16 Denmark, 17 Australia, 18 and the UK, 4 among others.…”

Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer

“…Historically, these were industrial and mining provinces. Apart from tobacco consumption, exposure to asbestos 32 , 33 , polycyclic aromatic hydrocarbons 34 , 35 or PM 36 , 37 are highlighted in the literature as other LOCP (and lung cancer) risk factors. Between 1914 and 1918, there was a coal boom in Asturias, increasing the number of coal miners from 18,000 to 39,000, making it the main province for national coal production 38 .…”

Μελέτη Των Ορυκτών Αμιάντου Και Τρόποι Ανίχνευσης Των Ινών Τους Στο Περιβάλλον

“…Φινλανδία (Meurman et al, 1974, Vilkman et al, 1993, Koskinen et al, 2003, N. Αφρική (Bonn, 1999, Rees et al, 1999, Abratt, 2004, Braun & Kisting, 2006, Phillips et al, 2016, Γαλλία (Banaei et al, 2000, Meguellati-Hakkas et al, 2006, Gramond et al, 2012, Αυστρία (Neuberger & Vutuc, 2003), Ζιμπάμπουε (McCulloch, 2003, Ολλανδία (Burdorf et al, 2003), Αίγυπτο (Gaafar & Eldin, 2005), Ινδία (Subramanian & Madhavan, 2005, Ansari et al, 2007, Jadhav & Gawde, 2019, Βραζιλία (Berman, 1986, Giannasi & Thébaud-Mony, 1999, Fernandes et al, 2019, Ισπανία (Artieda et al, 2005), Δανία (Würtz ετ αλ., 2020) κ.ά., ενώ υπήρξε και μεγάλο ενδιαφέρον για την απελευθέρωση ινών αμιάντου από την κατάρρευση του Παγκοσμίου Κέντρου Εμπορίου, με το τρομοκρατικό χτύπημα της 11/9/2001 στη Νέα Υόρκη (Budgen, 2004, Lange, 2004, Nolan et al, 2005, Swayze et al, 2009, Li et al, 2012, de la Hoz et al, 2018.…”