Environmental management for dengue control: a systematic review protocol

Abstract

IntroductionDengue is among the most important mosquito-borne diseases, with more than half of the world’s population at risk of infection in dengue endemic countries. Environmental management, which includes any activities that involve environmental modification, environmental manipulation and changes to human behaviour have been used to mitigate the risk of dengue transmission. In this protocol, we will integrate the data from various sources to assess the overall effect of environmental management on the incidence of dengue and other entomological indices.Methods and analysesWe will conduct a systematic review of intervention that assess the effect of environmental management on the incidence of dengue and/or entomological indices. We will include any studies that include intervention through environmental management for dengue control, involving environmental modification, environmental manipulation and changes to human behaviour. A comprehensive search will be performed in electronic databases PUBMED, CENTRAL, SCOPUS, Web of Science and relevant research websites such as PROPSERO, WHO ICTRP and ClinicalTrials.gov to identify studies that meet our inclusion criteria. A systematic approach to searching, screening, reviewing and data extraction will be applied based on Preferred Reporting Items for Systematic reviews and Meta-Analysis. Titles, abstract, keywords for eligibility will be examined independently by researchers. The quality of the included studies will be assessed using quality assessment tool for studies with diverse design and Cochrane risk of bias tool. The characteristics of the selected articles will be described based on the study design, types of intervention and outcomes of the study in various countries. These include the types of environmental management intervention methods and the effectiveness of the intervention in reducing dengue cases or incidence and impact on entomological indices.Ethics and disseminationWe will register this systematic review with the National Medical Research Register, Ministry of Health Malaysia. This protocol also had been registered with the PROSPERO. No ethical approval is necessary, as there will be no collection of primary data. The results will be disseminated though a peer-reviewed publication and conference presentation.Trial registration numberCRD42018092189.

Geographic Partitioning of Dengue Virus Transmission Risk in Florida

“…However, as some seronegative recipients have developed clinical signs reminiscent of antibody-dependent enhancement of DENV infection leading to severe dengue, this vaccine is limited to those with proof of previous dengue infection [5]. Due to the lack of preventative interventions, the current best practices for DENV prevention rely heavily on mosquito vector control, although this approach is insufficient to completely prevent DENV transmission [6][7][8][9][10][11].…”

Blood Meals With Active and Heat-Inactivated Serum Modifies the Gene Expression and Microbiome of Aedes albopictus

“…This mosquito has an opportunistic feeding pattern ( Delatte et al, 2010 ; Kamgang et al, 2012 ), which increases the risk of transmission of zoonotic diseases to humans. Due to the lack of therapeutic options or widely available vaccines against human arbovirus infections, control of mosquito population is the most used way to prevent diseases transmission ( Mahmud et al, 2019 ). To halter expansion of this mosquito and control pathogen transmitted by it, we need a better understanding of its biology that will lead to innovative and effective control strategies.…”

Data quality and arbovirus infection associated factors in pregnant and non-pregnant women of childbearing age in Brazil: A surveillance database analysis

“…Imposing a potential risk of infection to approximately half of the world population and about 50 to 100 million new cases annually, dengue is deemed to be the arbovirus of enormous international relevance. However, is estimated that the number of infected people may be much higher due to underreporting [ [1] , [2] , [3] ].…”

“…Evaluated as the country in the Latin American and Caribbean region with the highest burden of pathologies related to neglected diseases, Brazil also ranks among the nations with the highest number of dengue cases [ 4 ]. The combination of environmental conditions conducive to the proliferation of the vector Aedes aegypti (rainfall, temperature, relative humidity, deforestation); disorderly occupation of urban areas; deficient health infrastructure; ineffective preventive interventions favored viral amplification and transmission, making arbovirus endemic in the country [ 2 , 3 , 5 , 6 ].…”