Enteric pH responsive cargo release from PDA and PEG coated mesoporous silica nanoparticles: a comparative study in<i>Drosophila melanogaster</i>

Sapre, Nidhi; Chakraborty, Rusha; Purohit, Poorvi; Bhat, Suresh; Das, Gaurav; Bajpe, Sneha

doi:10.1039/c9ra11019d

Cited by 12 publications

(7 citation statements)

References 89 publications

(108 reference statements)

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“…Another example of PDA coating on porous structures such as mesoporous silica NPs loaded with a fluorescent dye was successfully achieved by Sapre et al as an alternative drug delivery nanocarriers [103]. The particles were fed to Drosophila melanogaster to test their pH-responsive cargo release behaviour.…”

Section: Biomedical Applications Of Pda Coatingsmentioning

confidence: 99%

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

et al. 2020

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Biological structures have emerged through millennia of evolution, and nature has fine-tuned the material properties in order to optimise the structure-function relationship. Following this paradigm, polydopamine (PDA), which was found to be crucial for the adhesion of mussels to wet surfaces, was hence initially introduced as a coating substance to increase the chemical reactivity and surface adhesion properties. Structurally, polydopamine is very similar to melanin, which is a pigment of human skin responsible for the protection of underlying skin layers by efficiently absorbing light with potentially harmful wavelengths. Recent findings have shown the subsequent release of the energy (in the form of heat) upon light excitation, presenting it as an ideal candidate for photothermal applications. Thus, polydopamine can both be used to (i) coat nanoparticle surfaces and to (ii) form capsules and ultra-small (nano)particles/nanocomposites while retaining bulk characteristics (i.e., biocompatibility, stability under UV irradiation, heat conversion, and activity during photoacoustic imaging). Due to the aforementioned properties, polydopamine-based materials have since been tested in adhesive and in energy-related as well as in a range of medical applications such as for tumour ablation, imaging, and drug delivery. In this review, we focus upon how different forms of the material can be synthesised and the use of polydopamine in biological and biomedical applications. platform is highlighted ( Figure 1A). Then, theoretical and experimental proof of the chemical formation of polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applications are envisaged. Materials 2019, 12, x FOR PEER REVIEW 2 of 22polydopamine-based structures is summarised ( Figure 1B,C). This is then followed by descriptions of the unique (physicochemical) properties of polydopamine. Their applications as adhesive and in energy-related applications are also highlighted ( Figure 1D). Throughout, their wide range of applications in the biomedical field (thanks to their biocompatibility) is thoroughly explained. This includes examples of theranostic and drug delivery applications derived from different types of polydopamine-based configurations: adhesive, particle coating agent, capsule, and NPs/composites, respectively ( Figure 1C,E). Lastly, some challenges to make PDA into functional tools for future clinical applicatio...

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Section: Biomedical Applications Of Pda Coatingsmentioning

confidence: 99%

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

et al. 2020

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“…At pH 4.0 and 7.0, the release of 2,4-D was fitted well by the Higuchi model, indicating that the erosion and swelling of MIL-101(Fe) were negligible, and the diffusion coefficient of the pesticides was constant. However, THIA was more in line with the Ritger–Peppas model, which might be related to the slow dissolution of PDA in acidic conditions . At pH 10.0, the release of THIA and 2,4-D was fitted better with a first-order model, indicating the concentration-dependent release behaviors under alkaline conditions.…”

Section: Resultsmentioning

confidence: 99%

Facile Synthesis of the Dual Pesticide-Loaded Metal–Organic Framework Hybrid for pH-Responsive Release

Wang

Yang

et al. 2022

ACS Agric. Sci. Technol.

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Controlled release formulations, used for the long-term preservation of pesticides, make agricultural development more precise, efficient, and safe. However, facile synthesis and high utilization of these formulations remain challenging. In this work, a polydopamine and metal−organic framework (MOF) hybrid was fabricated by a facile synthesis strategy for the controlled delivery of insecticide thiacloprid (THIA) and herbicide 2,4-D. The pesticides exhibited environment-responsive release behaviors. After 24 h, the cumulative release of THIA and 2,4-D reached 52.78 and 58.63% under alkaline conditions. The antiultraviolet photodegradation ability of THIA and 2,4-D increased nearly 4 times and 2 times, respectively. Significant insecticidal and herbicidal properties were observed

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“…The PDA-coated RhB @MSN sample has higher negative potential at neutral pH resulting in a higher release of the dye when compared to uncoated RhB@ MSN. 136 systems. 137 Based on the above characteristics of NH 4 HCO 3 , PDA-coated hollow CeO 2 NPs can avail CeO 2 to be a pHsensitive drug delivery system with excellent photothermal performance.…”

Section: ■ Synthetic Polymers Membrane Coatingmentioning

confidence: 99%

“…Sapre et al synthesized PDA-coated mesoporous silica nanoparticles (MSNs) loaded with a fluorescent dye and fed them to individual adult flies. The PDA-coated RhB @MSN sample has higher negative potential at neutral pH resulting in a higher release of the dye when compared to uncoated RhB@MSN . However, slow and passive drug release controlled by pH value compromises antitumor effectiveness.…”

Section: Polyphenols Membrane Coatingmentioning

confidence: 99%

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

Wang

et al. 2022

ACS Materials Lett.

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Antitumor nanoparticles now confront several obstacles, including poor biocompatibility and biodegradability, quick removal, and a short cycle time, given the growing interest in surface membrane coating as a versatile platform for altering nanoparticles and overcoming the limitations of current nanodrug delivery methods. This paper reviews the recent progress of cells, synthetic polymers, polyphenols, and polysaccharides membrane coatings with favorable biocompatibility and biodegradability and easy surface modification on the surface of antitumor nanoparticle platforms, which can provide a promising strategy for endowing nanoparticles with specific and expected performance to optimize the efficiency of antitumor. Furthermore, multiple membrane combination strategies and additional biorecognition ligands modification on the membrane surface are supplied in an attempt to tackle the challenges of single membrane coating in a variety of tumor therapeutic applications and ultimately facilitate effective clinical transformation.

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Enteric pH responsive cargo release from PDA and PEG coated mesoporous silica nanoparticles: a comparative study inDrosophila melanogaster

Abstract: Targeted delivery in Drosophila middle mid-gut at pH < 4.0.

Cited by 12 publications

References 89 publications

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

From Bioinspired Glue to Medicine: Polydopamine as a Biomedical Material

Facile Synthesis of the Dual Pesticide-Loaded Metal–Organic Framework Hybrid for pH-Responsive Release

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

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