Enhancement of orthodontic anchorage and retention by the local injection of strontium: An experimental study in rats

Abstract

The local injection of strontium can inhibit the degree of experimental and relapsed tooth movement in a rat model.

Could medications and biologic factors affect post‐orthodontic tooth movement changes? A systematic review of animal studies

“…Subsequently, another nine studies were excluded: 2 as not studying post‐movement changes, 1 as involving humans, 1 with subjects exhibiting pathological conditions, 2 involving fewer than five subjects per experimental group, 1 studying gene transfer and 2 articles in journals that could not be retrieved despite repeated efforts (Table ). Finally, 17 full‐text study reports were considered eligible and their results were presented 35‐51 …”

“…The retrieved papers included investigation of the following administered substances: ketorolac; 36 tetracycline; 49 the antihyperlipidemics atorvastatin, 40 simvastatin; 38,39,41,48 the bisphosphonates alendronate, 44 pamidronate 45 and risedronate; 35 osteoprotegerin (OPG); 43,46 relaxin; 42,47 strontium ranelate; 37 raloxifene; 50 and psoralen 51…”

“…Assessment of the risk of bias resulted in seven studies being considered as unclear, 37,40‐42,46,50,51 eight of high 35,36,43‐45,47‐49 and two of low risk of bias 38,39 …”

Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

“…They noted that the strontium injections led to significant inhibition of both tooth movement and relapse movement, and that "histological examinations showed that strontium enhanced the number of osteoblasts and reduced the number of osteoclasts". 31 Forsgren et al showed that incorporating strontium into the surfaces of orthopedic and dental implants accelerated bone healing. 24 Hao et al found that the use of strontium hydroxyapatite and alginate in an injectable in situ gel-forming system resulted in shorter healing times in a rat calvarial model compared with conventional graft surgery, and that the animals showed no signs of inflammation.…”

Procedimientos Ortodónticos Mecánicos Y No Mecánicos en Recidiva Y Retención: Revisión De Cobertura Temática

“…44 Others studies in treatment models, such as the application of strontium in Wistar rats, show an inhibitory effect of osteoclast production and osteoblast enhancer, which trigger a relapse stop by local use of injections on teeth affected by orthodontic forces. 45 There are other relevant in-treatment studies with aspirin as an effective anti-relapse modulator through the control of Th1-mediated response, and molecules such as TNF-α and other immunomodulators. 46…”