Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats

Rogalska, Joanna; Brzóska, Małgorzata M.; Roszczenko, Alicja; Moniuszko-Jakoniuk, J

doi:10.1016/j.cbi.2008.09.011

Cited by 100 publications

(84 citation statements)

References 37 publications

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“…A positive effect of Zn co-treatment has also been proven in an in vitro study (44) performed on Caco-2 TC7l cells -a model system for the investigation of intestinal epithelium. Moreover, literature data indicate that not only does Zn supplementation ameliorate the Cd-induced disturbances of Zn levels, but it also influences and prevents Cd atherogenic effects through its effect on lipid metabolism whereby it prevents hyperlipidemia and hypercholesterolemia (29,45).…”

Section: Bulat Z Et Al Can Zinc Supplementation Ameliorate Cadmium-mentioning

confidence: 99%

“…On the other hand, there is growing evidence that supplementation with certain essential elements, especially Zn, could have a protective role against Cd toxicity (27)(28)(29)(30)(31). The antagonism between Cd and Zn is well documented and is probably one of the most investigated toxic metalbioelement interactions (32,33).…”

mentioning

confidence: 99%

“…The antagonism between Cd and Zn is well documented and is probably one of the most investigated toxic metalbioelement interactions (32,33). Thus, Rogalska et al (29) concluded that Zn supplementation during chronic cadmium exposure may have a protective role against the proatherogenic action of Cd by preventing hyperlipidemia and lipid peroxidation in rats. The hepatoprotective Zn impact, observed in a prolonged Cd treatment of rats, was attributed to the antioxidative, antiapoptotic, and antiinflammatory properties of Zn, as well as to its ability to stimulate regenerative processes and to reduce non-MTbound Cd levels in the liver (30,34).…”

mentioning

confidence: 99%

“…A beneficial, i.e. protective role of Zn against Cd toxicity is rather well documented and is prevalently explained by the ability of Zn to ameliorate Cd-induced oxidative stress, apoptosis, and necrosis (28,29,39).…”

mentioning

confidence: 99%

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Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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The study was designed to investigate the influence of zinc (Zn) supplementation on cadmium-induced alterations in zinc, copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of cadmium (Cd), Zn, Cu, and Mg were estimated in the blood, liver, kidney, and bone. The rabbits were divided in a control group, a Cd group-animals intoxicated orally with Cd (10 mg kg -1 bw, as aqueous solution of Cd-chloride), and a Cd+Zn group-animals intoxicated with the same dose of Cd and co-treated with Zn (20 mg kg -1 bw, as aqueous solution of Zn-sulphate). Solutions were administered orally, every day for 28 days. Sample mineralisation was performed with concentrated nitric acid (HNO 3 ) and perchloric acid (HClO 4 ) (4:1) and metal concentrations were determined by atomic absorption spectrophotometry (AAS). Zinc supplementation improved some of Cd-induced disturbances in bioelement levels in the investigated tissues. Beneficial effects of Zn on Zn and Cu levels were observed in blood, as well as on the Cu kidney level. The calculated values for Cu/Zn, Mg/Zn, and Mg/Cu ratios in blood suggest that Zn co-treatment reduces Cd-induced changes in bioelement ratios in blood.

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Section: Bulat Z Et Al Can Zinc Supplementation Ameliorate Cadmium-mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat

Đukić-Ćosić²,

Antonijević³

et al. 2017

Archives of Industrial Hygiene and Toxicology

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“…Literature data indicate the protective role of Zn supplementation against Cd toxicity, possibly because it stimulates metallothionein synthesis and competes with Cd for enzyme-binding sites (14,67,(76)(77)(78). In addition, some studies have shown favourable effects of pretreatment with other essential elements on Cd toxicity (79,80).…”

Section: Therapy Of Cadmium Poisoningmentioning

confidence: 99%

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Matović

Buha

Bulat

et al. 2011

Archives of Industrial Hygiene and Toxicology

179

122

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Discovered in late 1817, cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to fi nd out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically effi cient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has benefi cial effect under condition of cadmium exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These fi ndings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.

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Smoking and Cardiovascular Diseases

Bernhard¹

2011

Cigarette Smoke Toxicity

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Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats

Cited by 100 publications

References 37 publications

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Smoking and Cardiovascular Diseases

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