Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Matović, Vesna; Buha, Aleksandra; Bulat, Zorica; Đukić-Ćosić, Danijela

doi:10.2478/10004-1254-62-2011-2075

Cited by 172 publications

(128 citation statements)

References 67 publications

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“…The increased cadmium contents in the animal organism can affect the metabolism of many other essential elements such as selenium, manganese, chromium, magnesium, sodium, potassium, etc. (Matovic et al 2011). Therefore, the supplementation of the organism with essential elements can lead to improvement of animal health status as described by Kusakabe et al (2008) in the case of Fe, Cu, and Zn.…”

Section: Introductionmentioning

confidence: 99%

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Vlčková¹,

Malinová²,

Koubková³

et al. 2014

CZECH J ANIM SCI

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ABSTRACT:The long-term accumulation of risk elements (As, Cd, Pb) originated from differently contaminated soils in rat organism was investigated during a model two-generation experiment. The effect of soil contamination level, gender, and length of exposure as well as the interactions between risk elements and selected essential macro-and microelements were studied. Rat diet contained 10% of individual soils (based on dry weight): (i) Fluvisol heavily polluted by As, Cd, Zn, and Pb, (ii) Luvisol contaminated by As, Cd, and Zn, and (iii) uncontaminated Chernozem. Male and female Wistar rats used for the experiment were housed in cages in a room with controlled temperature for 60 days and were fed ad libitum the mentioned diets. Subsequently, the pregnant females were continuously fed the experimental diet until weaning when the young animals were separated to male and female and fed the experimental diet till day 110 of age. The element contents in rat tissues reflected the risk element contents in contaminated soils. The bioaccessibility and bioavailability of the risk elements decreased in the order Cd>As>Pb and was affected by the soil physicochemical parameters. No significant differences were observed between male and female rats as well as between the first and the second generation. However, interactions were reported among the risk elements where the high cadmium content in Fluvisol resulted in increasing arsenic accumulation in the rat liver. Moreover, arsenic-copper interactions were observed where significant increase of the copper level was determined in kidney of the animals fed Luvisol exceeding 50-fold the maximum permissible limits for As content in agricultural soils. Among the hematological and biochemical characteristics of rats, total erythrocyte count (Er), hematocrit (Hct) increased confirming adverse effect of soil-derived risk elements especially in male rats.

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Section: Introductionmentioning

confidence: 99%

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Vlčková¹,

Malinová²,

Koubková³

et al. 2014

CZECH J ANIM SCI

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“…It main target point of toxicity is liver and kidney after absorption. Cadmium induces it deleterious effects through generation of oxidative stress (Matovi´c et al, 2011) and also affect liver functioning and metabolism. Valko et al (2005) earlier reported that cadmium toxicity induces oxidative stress, promotes lipid peroxidation actively and depletes glutathione.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of methanol extract of Telfairia occidentalis Hook. and Amaranthus hybridus Linn. against cadmium induced oxidative stress in rats

2017

J App Pharm Sci

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Oxidative stress caused by cadmium in living systems leading to various clinical interpretations has been well documented. The study investigated if methanol extract of Telfairia occidentalis and Amaranthus hybridus could ameliorate the toxicity caused by cadmium. Administration of cadmium lead to an increase in lipid peroxidation marker MDA 0.42+018, 1.66+1.13 and reduced the concentration of enzymatic antioxidants SOD 10.22+2.13, 10.92+0.54, Catalase 22.82+14.74, 19.90+1.16 and GSH 18.02+0.49, 12.89+085 in liver and kidney of the rats. Result for liver function assay showed a significant increase in AST 24.00+3.31, ALT 60.40+10.85 and ALP 78.05+15.75 in the serum of rats administered cadmium without treatment. Total protein concentration was significantly higher in the vegetable treated group when compared to the group administered cadmium without treatment 3.72+041. Kidney function assay, creatinine and urea were significantly high in the rat administered cadmium without treatment when compared to the rats that received the vegetables. Phytochemical screening showed the presence of flavonoids, phenols, alkaloid in high concentration in the vegetables. In vitro antioxidant reflected high radical scavenging activity. From the result of this study, the vegetable showed robust ameliorative effect on cadmium induced toxicity which can be labelled to the rich antioxidant content of the vegetables and also the ability of the vegetable to promote phase 2 bio-transformation of xenobiotic.

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“…Finally, if an association between cadmium exposure and ME/CFS is demonstrated, also the management of the syndrome could be affected. Thus, nutritional supplementation of magnesium and zinc have been proposed in the prophylaxis and therapy of cadmium exposure [32], and it is interesting to notice that an old randomised controlled trial comparing a magnesium supplement with placebo found beneficial effects of magnesium on ME/CFS patients' symptom profiles [33].…”

Section: Consequences Of the Hypothesis And Discussionmentioning

confidence: 99%

Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

et al. 2012

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a b s t r a c tAccording to the World Health Organization, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/ CFS) is a neurological disease characterized by widespread inflammation and multi-systemic neuropathology. Aetiology and pathogenesis are unknown, and several agents have been proposed as causative agents or as factors perpetuating the syndrome. Exposure to heavy metals, with particular reference to mercury and gold in dental amalgams, has been considered among the triggers of ME/CFS. Here we hypothesize that cadmium, a widespread occupational and environmental heavy metal pollutant, might be associated with some of the neurological findings described in ME/CFS. In fact, ME/CFS patients show a decrease of the volume of the gray matter in turn associated with objective reduction of physical activity. Cadmium induces neuronal death in cortical neurons through a combined mechanism of apoptosis and necrosis and it could then be hypothesized that cadmium-induced neuronal cell death is responsible for some of the effects of cadmium on the central nervous system, i.e. a decrease in attention level and memory in exposed humans as well as to a diminished ability for training and learning in rats, that are symptoms typical of ME/CFS. This hypothesis can be tested by measuring cadmium exposure in a cohort of ME/CFS patients compared with matched healthy controls, and by measuring gray matter volume in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. In addition, we hypothesize that cadmium exposure could be associated with reduced cerebral blood flow in ME/CFS patients because of the disruptive effects of cadmium on angiogenesis. In fact, cadmium inhibits angiogenesis and low global cerebral flow is associated with abnormal brain neuroimaging results and brain dysfunction in the form of reduced cognitive testing scores in ME/CFS patients. This hypothesis can be tested by measuring cerebral cortex blood flow in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. If our hypothesis is demonstrated correct, the consequences could affect prevention, early diagnosis, and treatment of ME/CFS. Implications in early diagnosis could entail the evaluation of symptoms typical of ME/CFS in cadmium-exposed subjects as well as the search for signs of exposure to cadmium in subjects diagnosed with ME/CFS. Nutritional supplementation of magnesium and zinc could then be considered, since these elements have been proposed in the prophylaxis and therapy of cadmium exposure, and magnesium was demonstrated effective on ME/CFS patients' symptom profiles.

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Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium

Cited by 172 publications

References 67 publications

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats

Ameliorative effect of methanol extract of Telfairia occidentalis Hook. and Amaranthus hybridus Linn. against cadmium induced oxidative stress in rats

Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

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