Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Bulat, Zorica; Đukić-Ćosić, Danijela; Antonijević, Biljana; Buha, Aleksandra; Bulat, Petar; Pavlović, Zoran; Matović, Vesna

doi:10.1515/aiht-2017-68-2919

Cited by 31 publications

(19 citation statements)

References 50 publications

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“…Even though exposure to Pb and Cd has been shown to interfere with essential metals in many tissues (15,30,(51)(52)(53), our findings fail to confirm this in the rat brain. No visible interference in the brain was also reported by other similar studies (54,55).…”

Section: Discussioncontrasting

confidence: 99%

Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture

Javorac

Djordjevic

Anđelković

et al. 2020

Archives of Industrial Hygiene and Toxicology

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Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential metal status in the brain of Wistar rats. Animals were randomised in four groups of six to eight rats, which received 15 or 30 mg/kg of Cd, 150 mg/kg of Pb, or 150 mg/kg of Pb + 15 mg/kg of Cd by gavage. The fifth, control, group received distilled water only. Co-treatment with Pb and Cd induced significant increase in malondialdehyde (MDA) and thiobarbituric acid-reactive substances (TBARS) compared to control and groups receiving either metal alone. This is of special importance, as MDA presence in the brain has been implicated in many neurodegenerative disorders. The groups did not significantly differ in Zn, Cu, Mn, and Fe brain levels. Our findings highlight the importance of metal mixture studies. Neurotoxicity assessments of single chemicals do not provide a real insight into exposure to mixtures in real life. Further research should look into interactions between these metals to reveal complex molecular mechanisms of their neurotoxicity.

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Section: Discussioncontrasting

confidence: 99%

Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture

Javorac

Djordjevic

Anđelković

et al. 2020

Archives of Industrial Hygiene and Toxicology

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“…This is supported by the fact that we measured lower serum values of Mg in all treated groups, with the most pronounced reduction in groups treated with Pb. Interaction between toxic metals and bioelements has been extensively studied by our research group and these studies confirmed many hypotheses; prolonged oral exposure to Cd significantly reduced Zn levels in blood and nine organs; Cd interferes with intestinal Mg absorption and affects its homeostasis; and Cd exposure results in negative effects on Mg, Zn, Cu, and even iron tissue levels [12,13,14,41,42,76,77].…”

Section: Discussionmentioning

confidence: 56%

“…The present body of knowledge suggests oxidative stress as one of the critical mechanisms of toxicity of both metals, even though neither of these metals is a Fenton’s metal [7,8,9,10]. Other possible mechanisms of toxicity are binding to oxygen, nitrogen, and sulphur ligands, which may affect numerous enzymes and proteins [7,11]; interaction with bioelements [12,13,14]; inhibition of apoptosis [15]; and changes in DNA structure and the inhibition of damaged DNA repair, which may lead to aberrant gene expression [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney

Andjelković

Djordjevic

Antonijević

et al. 2019

IJERPH

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Background: Cadmium and lead are widespread and non-biodegradable pollutants of great concern to human health. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and it is therefore of paramount importance to assess their toxicity. In this study, we investigated the toxicity of Cd and Pb alone and as a mixture in an animal model of acute exposure. Methods: Experimental groups received a single treatment of aqueous solution of Cd-chloride (15 and 30 mg/kg body weight (b.w.) and Pb-acetate (150 mg/kg b.w.), while the mixture group received 15 mg Cd/kg b.w. and 150 mg Pb/kg b.w. Toxic effects of individual metals and their mixture were investigated on hematological and biochemical parameters, and the redox status in the plasma, liver, and kidneys of treated Wistar rats. Results: Tissue-specific changes were recorded in various parameters of oxidative damage, while the accumulation of metals in tissues accompanied the disturbances of both hematological and biochemical parameters. It was observed that the level of toxic metals in tissues had a different distribution pattern after mixture and single exposure. Conclusions: Comprehensive observations suggest that exposure to Cd and Pb mixtures produces more pronounced effects compared to the response observed after exposure to single metal solutions. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic metals in the organisms.

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“…This conflicted finding was partly attributed to the observed higher Zn levels in the same group of patients and the relatively small sample size (65 participants). Indeed, Cd belongs to the same group of elements as zinc, and the number of common biological targets of the two metals abound [56][57][58][59][60]. The role of zinc in insulin regulation has been extensively examined [61][62][63].…”

Section: Insulin Resistance and Cadmium: Human Studiesmentioning

confidence: 99%

Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

Buha

Đukić-Ćosić

Ćurčić

et al. 2020

Toxics

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Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of “hyperglycemic” metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.

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Can zinc supplementation ameliorate cadmium-induced alterations in the bioelement content in rabbits?

Cited by 31 publications

References 50 publications

Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture

Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture

Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney

Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

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