Enhanced radical scavenging activity by antioxidant-functionalized gold nanoparticles: A novel inspiration for development of new artificial antioxidants

Nie, Zhou; Liu, Ke Jian; Zhong, Chuan‐Jian; Wang, Lanfen; Yang, Ying; Qiu, Tian; Liu, Yang

doi:10.1016/j.freeradbiomed.2007.06.011

Cited by 149 publications

(86 citation statements)

References 61 publications

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“…The antioxidant potential of gold nanoparticles has been reported earlier. 36 Moreover, Sg-AuNPs could also be combined with cosmetics to enhance skin texture and prevent aging symptoms. Abbreviations: sg-agNPs, siberian ginseng silver nanoparticles; sg-auNPs, siberian ginseng gold nanoparticles.…”

Section: Assessment Of Antioxidant Activitymentioning

confidence: 99%

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Abbai¹,

Mathiyalagan²,

Markus³

et al. 2016

IJN

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Pharmacologically active stem of the oriental herbal adaptogen, Siberian ginseng, was employed for the ecofriendly synthesis of Siberian ginseng silver nanoparticles (Sg-AgNPs) and Siberian ginseng gold nanoparticles (Sg-AuNPs). First, for metabolic characterization of the sample, liquid chromatography-tandem mass spectrometry analysis (indicated the presence of eleutherosides A and E), total phenol content, and total reducing sugar were analyzed. Second, the water extract of the sample mediated the biological synthesis of both Sg-AgNPs and Sg-AuNPs that were crystalline face-centered cubical structures with a Z-average hydrodynamic diameter of 126 and 189 nm, respectively. Moreover, Fourier transform infrared analysis indicated that proteins and aromatic hydrocarbons play a key role in the formation and stabilization of Sg-AgNPs, whereas phenolic compounds accounted for the synthesis and stability of Sg-AuNPs. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) assay determined that Sg-AgNPs conferred strong cytotoxicity against MCF7 (human breast cancer cell line) and was only slightly toxic to HaCaT (human keratinocyte cell line) at 10 µg⋅mL −1 . However, Sg-AuNPs did not display cytotoxic effects against both of the cell lines. The disc diffusion assay indicated a dose-dependent increase in the zone of inhibition of Staphylococcus aureus (ATCC 6538), Bacillus anthracis (NCTC 10340), Vibrio parahaemolyticus (ATCC 33844), and Escherichia coli (BL21) treated with Sg-AgNPs, whereas Sg-AuNPs did not show inhibitory activity. In addition, the 2,2-diphenyl-1-picrylhydrazyl assay demonstrated that both Sg-AgNPs and Sg-AuNPs possess strong antioxidant activity. To the best of our knowledge, this is the first report unraveling the potential of Eleutherococcus senticosus for silver and gold nanoparticle synthesis along with its biological applications, which in turn would promote widespread usage of the endemic Siberian ginseng.

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Section: Assessment Of Antioxidant Activitymentioning

confidence: 99%

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Abbai¹,

Mathiyalagan²,

Markus³

et al. 2016

IJN

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“…Recent studies have demonstrated that metal nanoparticles are potential antioxidants. Bimetallic nanoparticles consisting of gold and platinum are effective in quenching reactive oxygen species (ROS), including hydrogen peroxide (H 2 O 2 ) and the superoxide anion radical (O 2 À ), in a dose-dependent manner, 4) and gold nanoparticles enhance the antioxidant activity of vitamin E. 5) In addition nanoparticles of gold and platinum have been found to catalyze oxidation of NADH to NAD. 6,7) ROS have been implicated in bone metabolism.…”

Section: Gold Nanoparticles Inhibited the Receptor Activator Of Nuclementioning

confidence: 99%

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Sul¹,

Kim²,

Kyung³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

102

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“…On the other hand, materials based on functionalized AuNPs are regarded as one of the most important nanocomposites especially due to their biological and catalytic activities [23,24]. For example, assembly of chromanol group on AuNPs could efficiently enhance the activity of the vitamin E-derived antioxidant [25]; aptamer-conjugated AuNPs showed the advantages in detection of cancer cells by colorimetric assay [26], AuNPs supported on MgO for CO oxidation [27].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

Diem

Thao

Phú

et al. 2017

Journal of Chemistry

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Gold nanoparticles (AuNPs) in spherical shape with diameter of 6-35 nm stabilized by dextran were synthesized by -irradiation method. The AuNPs were characterized by UV-Vis spectroscopy and transmission electron microscopy. The influence of pH, Au 3+ concentration, and dextran concentration on the size of AuNPs was investigated. Results indicated that the smallest AuNPs size (6 nm) and the largest AuNPs size (35 nm) were obtained for pH of 1 mM Au 3+ /1% dextran solution of 5.5 and 7.5, respectively. The smaller Au 3+ concentration favored smaller size and conversely the smaller dextran concentration favored bigger size of AuNPs. AuNPs powders were prepared by spay drying, coagulation, and centrifugation and their sizes were also evaluated. The purity of prepared AuNPs powders was also examined by energy dispersive X-ray (EDX) analysis. Thus, the as-prepared AuNPs stabilized by biocompatible dextran in solution and/or in powder form can be potentially applied in biomedicine and pharmaceutics.

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Enhanced radical scavenging activity by antioxidant-functionalized gold nanoparticles: A novel inspiration for development of new artificial antioxidants

Cited by 149 publications

References 61 publications

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

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