Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Sul, Ok-Joo; Kim, Jin-Chun; Kyung, Tae-Wook; Kim, Hye-Jin; Kim, Youn-Young; Kim, Song-Hee; Kim, Ji-Soon; Choi, Hye-Seon

doi:10.1271/bbb.100375

Cited by 103 publications

(67 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Vargas et al [131] suggested that gold acts by inhibiting prostaglandin E2 and interleukin-1. Another study revealed association of gold nanoparticles with RANKL, a major inducer of osteoclast formation [132].…”

Section: Goldmentioning

confidence: 99%

Effects of thirty elements on bone metabolism

Dermience

Lognay

Mathieu³

et al. 2015

Journal of Trace Elements in Medicine and Biology

200

152

View full text Add to dashboard Cite

Section: Goldmentioning

confidence: 99%

Effects of thirty elements on bone metabolism

Dermience

Lognay

Mathieu³

et al. 2015

Journal of Trace Elements in Medicine and Biology

200

152

View full text Add to dashboard Cite

“…Furthermore, recent studies have demonstrated that GNPs have potential antioxidant effects (Barathmanikanth et al 2010;Sul et al 2010) and are effective in quenching reactive oxygen species, including H 2 O 2 and superoxide anion radicals (O 2 •) in a dosedependent manner (Kajita et al 2007). Although many reports have been released on the relationship of oxidative stress with inflammation, its role in inflammatory diseases remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

Ferreira

Cardoso

Vuolo

et al. 2015

Biochem. Cell Biol.

View full text Add to dashboard Cite

This study evaluated the parameters of oxidative stress and energy metabolism after the acute and long-term administration of gold nanoparticles (GNPs, 10 and 30 nm in diameter) in different organs of rats. Adult male Wistar rats received a single intraperitoneal injection or repeated injections (once daily for 28 days) of saline solution, GNPs-10 or GNPs-30. Twenty-four hours after the last administration, the animals were killed, and the liver, kidney, and heart were isolated for biochemical analysis. We demonstrated that acute administration of GNPs-30 increased the TBARS levels, and that GNPs-10 increased the carbonyl protein levels. The long-term administration of GNPs-10 increased the TBARS levels, and the carbonyl protein levels were increased by GNPs-30. Acute administration of GNPs-10 and GNPs-30 increased SOD activity. Long-term administration of GNPs-30 increased SOD activity. Acute administration of GNPs-10 decreased the activity of CAT, whereas long-term administration of GNP-10 and GNP-30 altered CAT activity randomly. Our results also demonstrated that acute GNPs-30 administration decreased energy metabolism, especially in the liver and heart. Long-term GNPs-10 administration increased energy metabolism in the liver and decreased energy metabolism in the kidney and heart, whereas long-term GNPs-30 administration increased energy metabolism in the heart. The results of our study are consistent with other studies conducted in our research group and reinforce the fact that GNPs can lead to oxidative damage, which is responsible for DNA damage and alterations in energy metabolism.

show abstract

“…GNPs catalyzed the oxidation of NADH to NAD, enhanced the antioxidant activity of vitamin E and decreased ROS induced in a hepatoma cell line (Nie et al, 2007;Martín et al, 2010) and inhibited osteoclast formation induced by the receptor activator of NF-kB ligand in bone marrow-derived macrophages (Sul et al, 2010). In another wound healing model, GNP decreased CD68 expression and increased SOD1 expression around the wound area, suggesting anti-inflammatory and antioxidative effects.…”

Section: Discussionmentioning

confidence: 97%

Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

et al. 2014

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects of therapeutic pulsed ultrasound with gold nanoparticles on oxidative stress parameters after traumatic muscle injury in Wistar rats. The animals were randomly divided into nine groups (n ¼ 6 each): sham (uninjured muscle); muscle injury without treatment; muscle injury and treatment with dimethyl sulfoxide (15 mg/kg); muscle injury and treatment with gold nanoparticles (27 mg); muscle injury and treatment with dimethyl sulfoxide + gold nanoparticles (Plus); muscle injury and therapeutic pulsed ultrasound; muscle injury and therapeutic pulsed ultrasound + dimethyl sulfoxide; muscle injury and therapeutic pulsed ultrasound + gold nanoparticles; and muscle injury and therapeutic pulsed ultrasound + Plus. Gastrocnemius injury was induced by a single-impact blunt trauma. Therapeutic pulsed ultrasound (6-min application, frequency 1.0 MHz, intensity 0.8 W/cm 2 ) was used 2, 12, 24, and 48 h after trauma. Mitochondrial superoxide generation, lipid peroxidation, and protein carbonylation, and the activities of superoxide dismutase, glutathione peroxidase, and catalase were evaluated. The increase in the superoxide production and TBARS and carbonyl levels observed in the control group after muscle damage were reduced in animals exposed to therapeutic pulsed ultrasound plus nanoparticles. Similarly, antioxidants enzymes showed a decreased activity with the same treatment. Our work suggest that therapeutic pulsed ultrasound + dimethyl sulfoxide + gold nanoparticles has beneficial effects on the muscle healing process by inducing a decrease in oxidative stress parameters and most likely decreasing the deleterious effects of the inflammatory response.

show abstract

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Cited by 103 publications

References 25 publications

Effects of thirty elements on bone metabolism

Effects of thirty elements on bone metabolism

Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

Contact Info

Product

Resources

About