Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

Victor, Eduardo Ghisi; Notoya, Frederico de Souza; Scheffer, Débora da Luz; Silva, Luciano da; Cantú, Roberto Benavides; Martinez, Virginia Hidolina Collins; Pinho, Ricardo A.; Paula, Marcos Marques da Silva

doi:10.3109/10717544.2014.923063

Cited by 20 publications

(18 citation statements)

References 55 publications

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“…However, in this study, we used a concentration of 70 mg.L -1 , which was shown to be toxic, because the gold levels that accumulate in the organs are proportional to the administered dosage (Lasagna-Reeves et al 2010). Other studies have been conducted using gold nanoparticles for the treatment of certain pathologies in which the NPs were revealed to be non-toxic, likely because they used smaller doses than was used in this current study (Zortea et al 2015;Silveira et al 2014;Dohnert et al 2014;Pereira et al 2012). …”

Section: Discussionmentioning

confidence: 84%

Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

Ferreira

Cardoso

Vuolo

et al. 2015

Biochem. Cell Biol.

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This study evaluated the parameters of oxidative stress and energy metabolism after the acute and long-term administration of gold nanoparticles (GNPs, 10 and 30 nm in diameter) in different organs of rats. Adult male Wistar rats received a single intraperitoneal injection or repeated injections (once daily for 28 days) of saline solution, GNPs-10 or GNPs-30. Twenty-four hours after the last administration, the animals were killed, and the liver, kidney, and heart were isolated for biochemical analysis. We demonstrated that acute administration of GNPs-30 increased the TBARS levels, and that GNPs-10 increased the carbonyl protein levels. The long-term administration of GNPs-10 increased the TBARS levels, and the carbonyl protein levels were increased by GNPs-30. Acute administration of GNPs-10 and GNPs-30 increased SOD activity. Long-term administration of GNPs-30 increased SOD activity. Acute administration of GNPs-10 decreased the activity of CAT, whereas long-term administration of GNP-10 and GNP-30 altered CAT activity randomly. Our results also demonstrated that acute GNPs-30 administration decreased energy metabolism, especially in the liver and heart. Long-term GNPs-10 administration increased energy metabolism in the liver and decreased energy metabolism in the kidney and heart, whereas long-term GNPs-30 administration increased energy metabolism in the heart. The results of our study are consistent with other studies conducted in our research group and reinforce the fact that GNPs can lead to oxidative damage, which is responsible for DNA damage and alterations in energy metabolism.

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Section: Discussionmentioning

confidence: 84%

Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

Ferreira

Cardoso

Vuolo

et al. 2015

Biochem. Cell Biol.

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“…Conversely, anti‐inflammatory and antioxidant effects can be enhanced when the nanoparticles are associated with antioxidant compounds. Our group has demonstrated the therapeutic potential of AuNP isolated or linked to N ‐acetylcysteine (NAC) in experimental models of muscle damage . However, it remains uncertain whether the isolated use of AuNP or the use of AuNP together with compound thiols such as NAC is more effective in acute inflammatory models.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles and/orN-acetylcysteine mediate carrageenan-induced inflammation and oxidative stress in a concentration-dependent manner

Paula

Petronilho

Vuolo

et al. 2015

J. Biomed. Mater. Res.

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We report the effect of gold nanoparticles (AuNP) in an acute inflammation model induced by carrageenan (CG) and compared this effect with those induced by the antioxidant N-acetylcysteine (NAC) alone and by the synergistic effect of NAC and AuNP together. Male Wistar rats received saline or saline containing CG administered into the pleural cavity, and some rats also received NAC (20 mg/kg) subcutaneously and/or AuNP administered into the pleural cavity immediately after surgery. Four hours later, the rats were sacrificed and pleural exudates obtained for evaluation of cytokine levels and myeloperoxidase activities. Oxidative stress parameters were also evaluated in the lungs. The results demonstrated that the inflammatory process caused by the administration of CG into the pleural cavity resulted in a substantial increase in the levels of tumor necrosis factor-α, interleukin-1β, and myeloperoxidase and a reduction in interleukin-10 levels. These levels seem to be reversed after different treatments in animals. Antioxidant enzymes exhibited positive responses after treatment of NAC + AuNP, and all treatments were effective at reducing lipid peroxidation and oxidation of thiol groups induced by CG. These findings suggest that small compounds, such as NAC plus AuNP, may be useful in the treatment of conditions associated with local inflammation.

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“…Ascorbic acid, glutathione and N-acetyl cysteine (a precursor of glutathione) are known antioxidants which have been known in clinical practice. If the glutathione production is genetically suppressed, the genotoxicity and cytotoxicity of AuNPs is reported to be increased (74).…”

Section: Special Case: Oxidation Stressmentioning

confidence: 99%

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

et al. 2016

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-Nanotechnology has opened a new horizon of research in various fields including applied physics, chemistry, electronics, optics, robotics, biotechnology and medicine. In the biomedical field, nanomaterials have shown remarkable potential as theranostic agents. Materials which are considered inert are often used in nanomedicine owning to their nontoxic profile. At nanoscale, these inert materials have shown unique properties that differ from bulk and dissolved counterparts. In the case of metals, this unique behavior not only imparts paramount advantages but also confers toxicity due to their unwanted interaction with different cellular processes. In the literature, the toxicity of nanoparticles made from inert materials has been investigated and many of these have revealed toxic potential under specific conditions. The surge to understand underlying mechanism of toxicity has increased and different means have been employed to overcome toxicity problems associated with these agents. In this review, we have focused nanoparticles of three inert metallic materials i.e. gold, silver and iron as these are regarded as biologically inert in the bulk and dissolved form. These materials have gained wider research interest and studies indicating the toxicity of these materials are also emerging. Oxidative stress, physical binding and interference with intracellular signaling are the major role player in nanotoxicity and their predominance is highly dependent upon size, surface coating and administered dose of nanoparticles. Current strategies to overcome toxicity have also been reviewed in the light of recent literature. The authors also suggested that uniform testing standards and well-designed studies are needed to evaluate nanotoxicity of these materials that are otherwise considered as inert.

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Effects of phonophoresis with gold nanoparticles on oxidative stress parameters in a traumatic muscle injury model

Cited by 20 publications

References 55 publications

Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

Gold nanoparticles and/orN-acetylcysteine mediate carrageenan-induced inflammation and oxidative stress in a concentration-dependent manner

Nanotoxicity of Inert Materials: The Case of Gold, Silver and Iron

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