Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

Diem, Phan Ha Nu; Thao, Doan Thi Thu; Phú, Đặng Văn; Duy, Nguyễn Ngọc; Quy, Hoang Thi Dong; Hòa, Trần Thái; Hiến, Nguyễn Quốc

doi:10.1155/2017/6836375

Cited by 18 publications

(18 citation statements)

References 39 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The higher permeability for PEI-Au may occur due to the higher affinity of dextrans towards AuNPs. Some authors reported that dextrans are used as stabilizers of colloidal AuNPs solution [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes

et al. 2021

View full text Add to dashboard Cite

Nanocomposite multilayered membrane coatings have been widely used experimentally to enhance biomedical materials surfaces. By the selection of reliable components, such systems are functionalized to be adjusted to specific purposes. As metal nanoparticles can reduce bacterial cell adhesion, the idea of using gold and silver nanoparticles of unique antimicrobial properties within membrane structure is outstandingly interesting considering dressings facilitating wound healing. The study was aimed to explore the interface between eukaryotic cells and wound dressing materials containing various nanoelements. The proposed systems are based on polyethyleneimine and hydroxyapatite thin layers incorporating metallic nanoparticles (silver or gold). To examine the structure of designed materials scanning electron and transmission electron microscopies were applied. Moreover, Fourier-transform infrared and energy-dispersive X-ray spectroscopies were used. Additionally, water contact angles of the designed membranes and their transport properties were estimated. The functioning of human fibroblasts was examined via flow cytometry to assess the biocompatibility of developed shells in the aspect of their cytotoxicity. The results indicated that designed nanocomposite membrane scaffolds support eukaryotic cells’ functioning, confirming that the elaborated systems might be recommended as wound healing materials.

show abstract

Section: Resultsmentioning

confidence: 99%

Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Researchers have also used various biomolecules or biopolymers to stabilize GNPs and increase their biocompatibility. Chitosan, alginate, gelatin, dextran, copolymers, and biosurfactants, etc., are examples of such molecules used as stabilizing agents for gold nanoparticles [66]. Recently, Spadavecchia et al used PEG as a stabilizing agent for GNPs, loaded them with doxorubicin, and decorated them with a polyclonal antibody to target pancreatic cancer cells [67].…”

Section: Nanomaterials As Carriers Of Biomolecules In Conjugatesmentioning

confidence: 99%

Present Scenario of Bioconjugates in Cancer Therapy: A Review

Wadhawan

Chatterjee

Singh

2019

IJMS

View full text Add to dashboard Cite

Cancer is one of the deadliest diseases and poses a risk to people all over the world. Surgery, chemo, and radiation therapy have been the only options available until today to combat this major problem. Chemotherapeutic drugs have been used for treatment for more than 50 years. Unfortunately, these drugs have inherent cytotoxicities and tumor cells have started inducing resistance against these drugs. Other common techniques such as surgery and radiotherapy have their own drawbacks. Therefore, such techniques are incompetent tools to alleviate the disease efficiently without any adverse effects. This scenario has inspired researchers to develop alternative techniques with enhanced therapeutic effects and minimal side effects. Such techniques include targeted therapy, liposomal therapy, hormonal therapy, and immunotherapy, etc. However, these therapies are expensive and not effective enough. Furthermore, researchers have conjugated therapeutic agents or drugs with different molecules, delivery vectors, and/or imaging modalities to combat such problems and enhance the therapeutic effect. This conjugation technique has led to the development of bioconjugation therapy, in which at least one molecule is of biological origin. These bioconjugates are the new therapeutic strategies, having prospective synergistic antitumor effects and have potency to overcome the complications being produced by chemo drugs. Herein, we provide an overview of various bioconjugates developed so far, as well as their classification, characteristics, and targeting approach for cancer. Additionally, the most popular nanostructures based on their organic or inorganic origin (metallic, magnetic, polymeric nanoparticles, dendrimers, and silica nanoparticles) characterized as nanocarriers are also discussed. Moreover, we hope that this review will provide inspiration for researchers to develop better bioconjugates as therapeutic agents.

show abstract

“…To date, AuNPs have been synthesized by radiation techniques using various polysaccharides for stabilization, such as dextran [15], hyaluronate [16], chitosan [13,17], and alginate [12,18]. Carboxymethyl chitosan (CM-chitosan), a derivative of chitosan, is a water-soluble and biocompatible polymer.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Carboxymethyl Chitosan-Capped Gold Nanoparticles by Gamma Irradiation with Novel Potential Applications as Antioxidant, Hepatoprotective, and Anticancer Substance

Linh

Nghĩa²,

Vu³

et al. 2021

Journal of Nanomaterials

View full text Add to dashboard Cite

Gold nanoparticles capped by carboxymethyl chitosan (AuNPs/CM-chitosan) with particle sizes of 5.2–7.3 nm were successfully synthesized by the γ-irradiation of Au3+ solutions. Their characteristics were analysed by transmission electron microscope images, powder X-ray diffraction patterns, UV-visible spectroscopy, and Fourier transform infrared spectra. The antioxidant activity of AuNP/CM-chitosan was time dependent and much higher than that of ascorbic acid at the same concentration. On the other hand, the results of tail vein injection of AuNP/CM-chitosan in mice indicated that this product was not toxic to mice and that AuNPs were mainly distributed in liver tissue, at approximately 77.5%, 6 h after injection. The hepatoprotective activity of AuNP/CM-chitosan was also tested in acetaminophen-induced hepatotoxic mice by oral administration at daily doses of 0.5–2 mg/head. The results indicated that compared to the control, supplementation with 2 mg of AuNPs/head strongly reduced the aspartate aminotransferase and alanine aminotransferase indexes in the blood of the tested mice by approximately 66.5 and 69.3%, respectively. Furthermore, the MTT (3[4,5 dimetylthiazol-2-yl]-2,5-diphenyltetrazol bromide) assay on a liver cancer cell line (HepG2) clearly confirmed strong anticancer activity on HepG2 cells treated with 0.05–0.5 mM AuNPs and the tested cells did not survive after treatment with 0.5 mM AuNPs, while the growth of the normal cell line (L929) has no significant effect at the same treated concentration of AuNPs. The AuNP/CM-chitosan in the present study was synthesized by the γ-irradiation method without using any toxic-reducing chemical and stabilized in a natural biocompatible polymer. The strong antioxidant, hepatoprotective, and anticancer effects of this product may be supported to be used in the biomedical field.

show abstract

Synthesis of Gold Nanoparticles Stabilized in Dextran Solution by Gamma Co-60 Ray Irradiation and Preparation of Gold Nanoparticles/Dextran Powder

Cited by 18 publications

References 39 publications

Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes

Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes

Present Scenario of Bioconjugates in Cancer Therapy: A Review

Synthesis of Carboxymethyl Chitosan-Capped Gold Nanoparticles by Gamma Irradiation with Novel Potential Applications as Antioxidant, Hepatoprotective, and Anticancer Substance

Contact Info

Product

Resources

About