Engineering pharmaceutical nanocarriers for photodynamic therapy on wound healing: Review

Shanmugapriya, Karuppusamy; Kang, Hyun Wook

doi:10.1016/j.msec.2019.110110

Cited by 79 publications

(44 citation statements)

References 187 publications

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“…The application of TiO 2 in PDT concerns its various forms, especially composites and hybrids, with some perspectives to use also in the area of wound healing application and management [44]. Archana et al obtained and characterized blends of chitosan, poly(N-vinylpyrrolidone) and TiO 2 by infrared spectroscopy, thermogravimetric analysis, transmission electron microscopy, and scanning electron microscopy [45].…”

Section: Photodynamic Activity Of Neat Tio 2 Nanoparticles and In Drumentioning

confidence: 99%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

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Metallic and metal oxide nanoparticles (NPs), including titanium dioxide NPs, among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites and combinations with other molecules or biomolecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 nanoparticles, leading to hybrid materials. These nanostructures can reveal increased light absorption, allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer and antimicrobial therapies, many approaches utilizing titanium dioxide were tested. Results of selected studies presenting the scope of potential uses are discussed in this review.

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Section: Photodynamic Activity Of Neat Tio 2 Nanoparticles and In Drumentioning

confidence: 99%

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

et al. 2020

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“…The second generation PSs combined with carrier can circumvent the skin barrier and improve selective delivery to melanoma cells (120,146,149,150,165). The use of nanocarriers can improve the activity of photosensitizing agents through preferential accumulation of the carrier at the tumor site and facilitating slow, controlled release of the PS (166). Nanocarriers function by binding to the target molecules of overexpressed receptors in tumor cells, leading to enhanced uptake of PS that have been conjugated with peptides, aptamers, and antibody fragments.…”

Section: Photosensitizersmentioning

confidence: 99%

Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma

Tan

Dong

et al. 2020

Front. Oncol.

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Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells.

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“…The application of TiO2 in PDT concerns its various forms, especially composites and hybrids, with some perspectives to use also in the area of wound healing application and management [44]. Archana et al obtained and characterized blends of chitosan, poly(N-vinylpyrrolidone) and TiO2 by infrared spectroscopy, thermogravimetric analysis, transmission electron microscope, and scanning electron microscope [45].…”

Section: Photodynamic Activity Of Neat Tio2 and In Drug Delivery Systemsmentioning

confidence: 99%

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

Ziental

Czarczyńska-Goślińska

Mlynarczyk

et al. 2020

Preprint

101

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Metallic nanoparticles (NPs), among polymeric NPs, liposomes, micelles, quantum dots, dendrimers, or fullerenes, are becoming more and more important due to their potential use in the novel medical therapies. Titanium dioxide (titanium(IV) oxide, titania, TiO2) is an inorganic compound that owes its recent rise in scientific interest to photoactivity. After the illumination in aqueous media with UV light, TiO2 produces an array of reactive oxygen species (ROS). The capability to produce ROS and thus induce cell death has found application in the photodynamic therapy (PDT) for the treatment of a wide range of maladies, from psoriasis to cancer. Titanium dioxide NPs were studied as photosensitizing agents in the treatment of malignant tumors as well as in photodynamic inactivation of antibiotic-resistant bacteria. Both TiO2 NPs themselves, as well as their composites with other molecules, can be successfully used as photosensitizers in PDT. Moreover, various organic compounds can be grafted on TiO2 NPs, leading to hybrid materials. These nanostructures can reveal increased light absorption allowing their further use in targeted therapy in medicine. In order to improve efficient anticancer therapy, many approaches utilizing titanium dioxide were tested. The most significant studies are discussed in this review.

show abstract

Engineering pharmaceutical nanocarriers for photodynamic therapy on wound healing: Review

Cited by 79 publications

References 187 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma

Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine

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Engineering pharmaceutical nanocarriers for photodynamic therapy on wound healing: Review

Cited by 79 publications

References 187 publications

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Titanium Dioxide Nanoparticles: Prospects and Applications in Medicine

Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma

Titanium Dioxide Nanoparticles &ndash; Prospects and Applications in Medicine

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Titanium Dioxide Nanoparticles – Prospects and Applications in Medicine