Engineering of axially vascularized bone tissue using natural coral scaffold and osteogenic bone marrow mesenchymal stem cell sheets

Weng, Yanming; Wang, Zhifa; Sun, Jianwei; Han, Lei; Xiao, Li; Wu, Buling; Dong, Qingshan; liu, Yanpu

doi:10.1016/j.jormas.2021.01.013

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…The results showed that the bionic cartilage scaf-fold could induce the proliferation and differentiation of MSCs and effectively repair the cartilage defect. It is worth noting that the lack of vascularization in addition to osteogenic induction is the next problem for stem cells to be solved by biological scaf-folds ( 52 ), Growth factors play an irreplaceable role in the regulation of angiogenesis and osteogenic differentiation. Therefore, future bone tissue engineering will focus on the composite of biological scaf-folds through different manufacturing technologies and the addition of growth factors and other chemotactic peptides to maximize the function of MSCs.…”

Section: Discussionmentioning

confidence: 99%

Research trends of mesenchymal stem cells application in orthopedics: A bibliometric analysis of the past 2 decades

Deng

Luo

Lin

et al. 2022

Front. Public Health

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BackgroundBibliometric analysis and visualization tools were used to determine the development trend of mesenchymal stem cells (MSCs) in orthopedics in the past 20 years, so as to guide researchers to explore new directions and hotspots in the field in the future.MethodsIn the Web of Science Core Collection, all articles about the application of MSCs in orthopedics from 2002 to 2021 were searched. The qualitative and quantitative analysis was performed based on Web of Science and CiteSpace software.ResultsA total of 2,207 articles were retrieved. After excluding non-article articles such as review and letter and non-English language articles, 1,489 articles were finally included. Over the past 2 decades, the number of publications on the application of MSCs in orthopedic diseases increased. Among them, the United States, China, Japan and the United Kingdom have made significant contributions in this field. The most productive institution was Shanghai Jiao Tong University. Journal of Orthopedic Research published the largest number of publications. The journal with the highest citation frequency was Experimental Hematology. The authors with the highest output and the highest citation frequency on average were Rochy S. Tuan and Scott A. Rodeo, respectively. “Mesenchymal stem cell”, “in vitro” and “Differentiation” were the top three keywords that appeared. From the keyword analysis, the current research trend indicates that the primary research hotspots of MSCs in orthopedics are the source of MSCs, in vitro experiments and the differentiation of MSCs into bone and cartilage. The frontiers of this field are the combination of MSCs and platelet-rich plasma (PRP), the treatment of knee diseases such as osteoarthritis, osteogenic differentiation, and the application of biological scaffolds combined with MSCs.ConclusionOver the past 2 decades, the application of MSCs in orthopedic diseases has received increasing attention. Our bibliometric analysis results provide valuable information and research trends for researchers in the field to understand the basic knowledge of the field, identify current research hotspots, potential collaborators, and future research frontiers.

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Section: Discussionmentioning

confidence: 99%

Research trends of mesenchymal stem cells application in orthopedics: A bibliometric analysis of the past 2 decades

Deng

Luo

Lin

et al. 2022

Front. Public Health

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“…Bone marrow mesenchymal stem cells (BMSCs), a population of cells with multi‐directional differentiation ability, which can differentiate into osteoblasts and become bone cells eventually, are necessary for bone regeneration and repair 19 . Weng et al 20 found that a large amount of bone tissue formed after implanting axially vascularized bone tissue using natural coral scaffold and BMSCs sheets into the inguinal region of rabbits for 12 weeks. BMSCs are therefore considered one of the most hopeful therapeutic candidates to improve bone regeneration in vitro and in vivo 21 .…”

Section: Introductionmentioning

confidence: 99%

The influences of PEG‐functionalized graphdiyne on cell growth and osteogenic differentiation of bone marrow mesenchymal stem cells

Huang

et al. 2023

J Biomed Mater Res

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Guided bone regeneration (GBR) is a frequently used technique for patients with insufficient alveolar bone. The discovery of bone substitutes that can enhance osteogenesis is critical for GBR. Graphdiyne (GDY), a newly discovered carbon-based nanomaterial, has been recognized as the most stable allotrope of acetylene carbon and is anticipated to be able to promote osteogenesis. Whereas it still remains unknown whether it could enhance osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In this study, GDY was modified with polyethylene glycol (PEG) and the influences of GDY-PEG at different concentrations on BMSCs cell growth and osteogenic differentiation were researched for the first time. In this study, we found that GDY-PEG at low concentration possessed premium bio-compatibility and revealed evident facilitation of BMSCs osteogenic differentiation. The cell growth and osteogenic differentiation of BMSCs treated with GDY-PEG were dose-dependent.GDY-PEG at 1 μg/mL demonstrated the optimal promoting effects of BMSCs osteogenic differentiation. Moreover, the regulating effect of BMSCs osteogenic differentiation by GDY-PEG might be associated with the Wnt/β-catenin signaling pathway. In all, the present study indicated a novel application of GDY in promoting bone tissue regeneration, providing a novel biomaterial for bone augmentation in clinics.

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Stem cells and common biomaterials in dentistry: a review study

Mosaddad

Rasoolzade

Namanloo

et al. 2022

J Mater Sci: Mater Med

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Stem cells exist as normal cells in embryonic and adult tissues. In recent years, scientists have spared efforts to determine the role of stem cells in treating many diseases. Stem cells can self-regenerate and transform into some somatic cells. They would also have a special position in the future in various clinical fields, drug discovery, and other scientific research. Accordingly, the detection of safe and low-cost methods to obtain such cells is one of the main objectives of research. Jaw, face, and mouth tissues are the rich sources of stem cells, which more accessible than other stem cells, so stem cell and tissue engineering treatments in dentistry have received much clinical attention in recent years. This review study examines three essential elements of tissue engineering in dentistry and clinical practice, including stem cells derived from the intra- and extra-oral sources, growth factors, and scaffolds.

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Engineering of axially vascularized bone tissue using natural coral scaffold and osteogenic bone marrow mesenchymal stem cell sheets

Cited by 5 publications

References 29 publications

Research trends of mesenchymal stem cells application in orthopedics: A bibliometric analysis of the past 2 decades

Research trends of mesenchymal stem cells application in orthopedics: A bibliometric analysis of the past 2 decades

The influences of PEG‐functionalized graphdiyne on cell growth and osteogenic differentiation of bone marrow mesenchymal stem cells

Stem cells and common biomaterials in dentistry: a review study

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