Engineered Biomimetic Membranes for Organ-on-a-Chip

Abstract

Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems. Here, we review the preparation and characterization of biomimetic membranes in comparison with the features of the extracellular matrix. After that, we review and discuss the latest applications of engineered biomimetic membranes to fabricate various organs on a chip, such as liver, kidney, intestine, lung, skin, heart, vasculature and blood vessels, brain, and multiorgans with perspectives for further biomedical applications.

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“…An immediate model of BM structure and functions is based on a stack of 2 or more microfluidic compartments communicating through semipermeable inserts. ,, Selecting or synthesizing suitable inserts for this purpose is a complex, multiparametric task. First of all, the permeable substrate needs to faithfully replicate both the biochemical and biophysical BM properties − to support cell adhesion, proliferation, and differentiation. , Practical manufacturing considerations, such as ease of handling, scalability, compatibility with microfluidic systems, and ability to consistently sustain appropriate shear stress levels, are also important.…”