Porous Polymeric Nanofilms for Recreating the Basement Membrane in an Endothelial Barrier-on-Chip
Elena Mancinelli,
Nanami Zushi,
Megumi Takuma
et al.
Abstract:Organs-on-chips (OoCs) support an organotypic human cell culture in vitro. Precise representation of basement membranes (BMs) is critical for mimicking physiological functions of tissue interfaces. Artificial membranes in polyester (PES) and polycarbonate (PC) commonly used in in vitro models and OoCs do not replicate the characteristics of the natural BMs, such as submicrometric thickness, selective permeability, and elasticity. This study introduces porous poly(D,L-lactic acid) (PDLLA) nanofilms for replicat… Show more
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