Enfermedad de Castleman. Análisis histopatológico e inmunohistoquímico de treinta y nueve casos

Sevilla-Lizcano, Diana Brisa; Frias-Soria, Christian Lizette; Ortíz-Hidalgo, Carlos

doi:10.24875/gmm.17003021

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Peru reported two cases of UCD hyaline that were KSHV positive by IHC [ 169 ]. We found only one PEL and three MCD reported from Mexico [ 170 , 172 , 173 ], and two PEL and one MCD from Cuba [ 179 , 187 ]. Figure 5 shows KSHV positive PEL and MCD.…”

Section: Kaposi Sarcoma Human Herpesvirusmentioning

confidence: 87%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.

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Section: Kaposi Sarcoma Human Herpesvirusmentioning

confidence: 87%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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“…unicentric presentation, of plasma cells of multicentric presentationwhich is manifested by generalized peripheral lymphadenopathy, hepatosplenomegaly, fever and nocturnal sweating-and the mixed one [2]. Unicentric form as a good prognosis while multicentric, which commonly occurs in a scenario of immunocompromised patients, as a high morbidity and mortality with few therapeutic options [6]. The following is the case of an immunocompetent patient who developed the disease, which is striking in itself, with an atypical clinical presentation.…”

mentioning

confidence: 99%

Castleman’s Disease about a Case

Ap¹,

Cp²,

Crc³

et al. 2019

J Clin Lab Med

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Castleman's disease is a very rare lymphoproliferative disorder. There are two Clinical forms: the unicentric, which is usually benign, and the multicentric progressive course. There are three described histological patterns: hyali neovascular of unicentric presentation, of plasma cells of multicentric presentation and the mixed one. The aim of this paper is to present a clinical case of multicentric Castleman's disease of hyaline vascular histology very little described in the literature. The patient started with asthenia, anorexia, profuse nocturnal sweating, weight loss, generalized lymphadenopathy, splenomegaly and respiratory episodes. At physical examination: multiple cervical, axillary and bilateral inguinal adenopathies. The diagnosis was made with the histopathological study of the resected ganglion, the evolution after the treatment has been favorable. Because there are no specific clinical and radiographic features, a high degree of diagnostic suspicion and the experience of the pathologist are required to diagnose this rare disease.

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Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report

Ekwere

Eziagu

2020

J Lab Physicians

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Castleman disease (CD), or angiofollicular hyperplasia, or giant lymph node hyperplasia, is a heterogeneous benign lymphoproliferative disorder of unknown etiology. It has three distinct histologic subtypes (hyaline vascular, plasma cell, and mixed hyaline vascular plasma cell types) as well as unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD) variants. In the unicentric form, the disease is confined to one anatomical lymph node and usually with no systemic symptoms. However, in the multicentric form (further subdivided into idiopathic MCD, human herpes virus-8-associated MCD, and POEMS-associated MCD), lymphadenopathy is more generalized with more aggressive systemic symptoms mimicking a malignant lymphoma. Therefore, this case report aims to underscore the importance of immunohistochemical evaluation as an indispensable ancillary technique to routine histopathological examination of a lymph node biopsy specimen, as a gold standard for definitive diagnosis of proliferative lymph node lesions.

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Enfermedad de Castleman. Análisis histopatológico e inmunohistoquímico de treinta y nueve casos

Cited by 4 publications

References 30 publications

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Castleman’s Disease about a Case

Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report

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