Endometriosis and ovarian cancer

Campbell, Ian; Thomas, Eric J.; Hitchcock, Andrew; Morland, Sarah J.; Jiang, Xin

doi:10.1111/j.1471-0528.1998.tb09981_7.x

Cited by 4 publications

(5 citation statements)

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“…This fact furnishes strong evidence that endometriosis is a precancerous lesion for both endometrioid and clear cell carcinomas. Using a molecular genetic approach, Campbell et al [81] and Jiang et al [82] detected genetic lesions common to the carcinoma and the adjacent endometriotic tissue; Obata et al [83] showed that endometrioid but not serous or mucinous epithelial ovarian tumors had frequent PTEN/MMAC mutations. In addition, the loss of PTEN immunoreactivity has been reported in a significantly higher percentage of clear cell and endometrioid ovarian cancers than cancers of other histologic types [84].…”

Section: Molecular Evidencementioning

confidence: 99%

Etiology and Pathogenesis of Epithelial Ovarian Cancer

et al. 2007

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Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer development. Among them, an inflammatory stromal microenvironment seems to play a critical role in the initiation of the disease. The interaction between such a microenvironment, genetic polymorphisms, and different epithelial components such as endosalpingiosis, endometriosis, and ovarian inclusion cyst in the ovarian cortex may induce different genetic changes identified in the epithelial component of different histological types of ovarian tumors. Genetic studies on different histological grades and types provide insight into the pathogenetic pathways for the development of different disease phenotypes. However, the link between all these genetic changes and the etiological factors remains to be established.

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Section: Molecular Evidencementioning

confidence: 99%

Etiology and Pathogenesis of Epithelial Ovarian Cancer

et al. 2007

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“…Endometrioid and clear cell tumors each account for 10% of epithelial ovarian cancers. These tumors are thought to arise from foci of endometriosis and endometriotic cysts within the ovary [ 7 , 8 ]. Different tumor subtypes are characterized by dysregulation in specific pathways and have important ramifications in disease prognosis and treatment response [ 9 - 11 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures

Saw

Yang

et al. 2012

BMC Cancer

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BackgroundAldehyde dehydrogenases belong to a superfamily of detoxifying enzymes that protect cells from carcinogenic aldehydes. Of the superfamily, ALDH1A1 has gained most attention because current studies have shown that its expression is associated with human cancer stem cells. However, ALDH1A1 is only one of the 19 human ALDH subfamilies currently known. The purpose of the present study was to determine if the expression and activities of other major ALDH isozymes are associated with human ovarian cancer and ovarian cancer sphere cultures.MethodsImmunohistochemistry was used to delineate ALDH isozyme localization in clinical ovarian tissues. Western Blot analyses were performed on lysates prepared from cancer cell lines and ovarian cancer spheres to confirm the immunohistochemistry findings. Quantitative reverse transcription-polymerase chain reactions were used to measure the mRNA expression levels. The Aldefluor® assay was used to measure ALDH activity in cancer cells from the four tumor subtypes.ResultsImmunohistochemical staining showed significant overexpression of ALDH1A3, ALDH3A2, and ALDH7A1 isozymes in ovarian tumors relative to normal ovarian tissues. The expression and activity of ALDH1A1 is tumor type-dependent, as seen from immunohistochemisty, Western blot analysis, and the Aldefluor® assay. The expression was elevated in the mucinous and endometrioid ovarian epithelial tumors than in serous and clear cell tumors. In some serous and most clear cell tumors, ALDH1A1 expression was found in the stromal fibroblasts. RNA expression of all studied ALDH isozymes also showed higher expression in endometrioid and mucinous tumors than in the serous and clear cell subtypes. The expression of ALDH enzymes showed tumor type-dependent induction in ovarian cancer cells growing as sphere suspensions in serum-free medium.ConclusionsThe results of our study indicate that ALDH enzyme expression and activity may be associated with specific cell types in ovarian tumor tissues and vary according to cell states. Elucidating the function of the ALDH isozymes in lineage differentiation and pathogenesis may have significant implications for ovarian cancer pathophysiology.

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“…Some have proposed unopposed estrogen as a factor (3) although for extragondal disease, three of those reported were pregnant at the time of diagnosis which would not support this theory. Others have provided genetic data suggesting that endometriosis is a premalignant condition although further evidence for this hypothesis is required (4) .…”

Section: Discussionmentioning

confidence: 99%

A case of clear cell carcinoma arising in extragonadal endometriosis

Todd

Kehoe

Gearty

2000

Int J Gynecol Cancer

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Malignancy developing in extragonadal endometriosis is rare with the majority of cases being endometrioid adenocarcinomas. We present a 54-year-old woman who developed a clear cell carcinoma in her perineum, 25 years after excision of a perineal endometrioma in an episiotomy scar. Treatment involved radiotherapy and surgery, with a view to preserving vaginal function. Where benign extragonadal endometriosis occurs, the potential for malignant transformation persists even years after primary treatment.

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Endometriosis and ovarian cancer

Cited by 4 publications

References 0 publications

Etiology and Pathogenesis of Epithelial Ovarian Cancer

Etiology and Pathogenesis of Epithelial Ovarian Cancer

Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures

A case of clear cell carcinoma arising in extragonadal endometriosis

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