Etiology and Pathogenesis of Epithelial Ovarian Cancer

Mok, Samuel C.; Kwong, Joseph; Welch, William R.; Samimi, Goli; Ozbun, Laurent; Bonome, Tomás; Birrer, Michael J.; Berkowitz, Ross S.; Wong, Kwong-Kwok

doi:10.1155/2007/474320

Cited by 43 publications

(59 citation statements)

References 75 publications

(70 reference statements)

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“…Most theories concerning the origin of ovarian cancer hypothesize that the cell of origin resides in the single-cell layer of epithelial cells, which cover the surface of the ovaries. Repeated trauma of this cellular layer by ovulation (incessant ovulation) with subsequent tissue repair has been proposed as a mechanism for the early transformation events for ovarian cancer [8,18]. This hypothesis is supported by the well-known correlation between total ovulatory cycles and the risk of developing ovarian cancer [18,[23][24][25].…”

Section: Origin Of Ovarian Cancermentioning

confidence: 95%

“…One of the major stumbling blocks has been the characterization of a mutually agreed upon precursor lesion and the identification of intermediate/transition lesions [18]. For example, there is controversy on whether the surface epithelium of the ovary displays abnormal lesions [19,20].…”

Section: Origin Of Ovarian Cancermentioning

confidence: 99%

“…Repeated trauma of this cellular layer by ovulation (incessant ovulation) with subsequent tissue repair has been proposed as a mechanism for the early transformation events for ovarian cancer [8,18]. This hypothesis is supported by the well-known correlation between total ovulatory cycles and the risk of developing ovarian cancer [18,[23][24][25]. Further, in vitro models involving rat and mouse ovarian surface epithelial cells in culture demonstrate transformation and chromosomal abnormalities with repeated passaging [26][27][28][29].…”

Section: Origin Of Ovarian Cancermentioning

confidence: 99%

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Genomic analysis of epithelial ovarian cancer

2008

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Ovarian cancer is a major health problem for women in the United States. Despite evidence of considerable heterogeneity, most cases of ovarian cancer are treated in a similar fashion. The molecular basis for the clinicopathologic characteristics of these tumors remains poorly defined. Whole genome expression profiling is a genomic tool, which can identify dysregulated genes and uncover unique sub-classes of tumors. The application of this technology to ovarian cancer has provided a solid molecular basis for differences in histology and grade of ovarian tumors. Differentially expressed genes identified pathways implicated in cell proliferation, invasion, motility, chromosomal instability, and gene silencing and provided new insights into the origin and potential treatment of these cancers. The added knowledge provided by global gene expression profiling should allow for a more rational treatment of ovarian cancers. These techniques are leading to a paradigm shift from empirical treatment to an individually tailored approach. This review summarizes the new genomic data on epithelial ovarian cancers of different histology and grade and the impact it will have on our understanding and treatment of this disease.

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Section: Origin Of Ovarian Cancermentioning

confidence: 95%

Section: Origin Of Ovarian Cancermentioning

confidence: 99%

Section: Origin Of Ovarian Cancermentioning

confidence: 99%

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Genomic analysis of epithelial ovarian cancer

2008

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“…Previously, it has been suggested that the origin of most ovarian carcinomas is from the ovarian surface epithelium or postovulatory inclusion cysts formed after follicular rupture and repair [1,2] . There are many hypotheses on the occurrence of ovarian carcinoma among women.…”

Section: Introductionmentioning

confidence: 99%

Ovarian carcinoma: An overview of current status

Lugani¹,

Asthana²,

Labani³

2016

Adv Mod Oncol Res

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Abstract:Ovarian carcinoma is one of the leading causes of morbidity and mortality associated with carcinomas affecting women. It comprises a heterogeneous group of neoplasms that represents the seventh most lethal malignancy in women worldwide, and is a major cause of death from gynecological carcinoma. Specific to different geographical locations all over the globe, there are variations in the magnitude and trends of ovarian carcinoma, and the scenario of the disease keeps changing. As such, it is necessary to update and review the existing study on ovarian carcinoma. Reviews on ovarian carcinoma from 2000 to 2015 were extracted from PubMed and Google Scholar, and a few selected landmark studies that incorporated old data were also included. The focus of the present study is to consolidate an updated global view on epithelial ovarian carcinoma, the most prevalent type of ovarian carcinoma. This article covers the epidemiology, types, diagnosis, prognosis, and treatment of epithelial ovarian carcinoma.

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“…It typically develops as an insidious disease (1,3,4), with few distinct symptoms until the tumor has become large or disseminated (2). Thus, EOC is not usually diagnosed prior to reaching an advanced stage, when the five-year survival rate is poor (1).…”

Section: Introductionmentioning

confidence: 99%

Impact of post-operative hormone replacement therapy on life quality and prognosis in patients with ovarian malignancy

Pan

Gao

et al. 2011

Oncology Letters

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Abstract. The present study aimed to assess the impact of post-surgical hormone replacement therapy (HRT) on life quality and prognosis in women with ovarian malignancy. HRT (Premarin, Nilestriol and medroxyprogesterone) was administered following surgery in 31 patients with ovarian cancer. A total of 44 ovarian cancer patients of similar age, clinical stage and pathological features did not receive HRT following surgery. The expression of estrogen receptor (ER)-α, ERβ and progesterone receptor (PR) in cancer tissues was detected by immunohistochemical staining. Serum levels of calcitonin (CT) and transforming growth factor (TGF)-α were determined by radioimmunoassay and enzyme-linked immunosorbent assay, respectively. Data were analyzed using Kaplan-Meier survival curves, a log-rank test and a Cox scale risk model. Quality of life was assessed in the patient groups and in healthy post-menopausal women (control) based on a questionnaire developed by the European Organization of Research and Treatment of Cancer (EORTC-C30), as well as our own specific questionnaire. A log-rank test revealed no difference in survival between the patients with and without HRT (p>0.05), and a Cox model showed that HRT was not an independent prognostic factor. The accumulated survival rate did not differ significantly based on the expression of ERα, ERβ or PR in patients with or without HRT (p>0.05). The serum TGFα levels prior to and following surgery were not significantly different in either of the two patient groups (p>0.05). Serum CT levels were higher in patients without HRT at 1.5 years following surgery (p<0.05), but no significant difference was found in the serum CT levels of patients receiving HRT. The HRT and non-HRT groups differed significantly with regard to the body and emotional functional sub-scales of the EORTC-C30 (p<0.05) and the sex quality and autonomic nerve maladjustment categories of our specific questionnaire (p<0.05). Findings of this study showed that HRT administered following surgery exhibited no apparent negative effect on prognosis in patients with ovarian cancer, regardless of ERα, ERβ or PR expression in cancer tissues, and had no effect on serum transforming growth factor (TGF)-α levels. Post-surgical HRT aided in the stabilization of serum CT levels and improved the quality of life in these patients.

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Etiology and Pathogenesis of Epithelial Ovarian Cancer

Cited by 43 publications

References 75 publications

Genomic analysis of epithelial ovarian cancer

Genomic analysis of epithelial ovarian cancer

Ovarian carcinoma: An overview of current status

Impact of post-operative hormone replacement therapy on life quality and prognosis in patients with ovarian malignancy

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