Ovarian carcinoma: An overview of current status

Lugani, Yogita; Asthana, Smita; Labani, Satyanarayana

doi:10.18282/amor.v2.i5.143

Cited by 4 publications

(6 citation statements)

References 85 publications

(106 reference statements)

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“…According to ICMR in 2012, breast cancer accounted for nearly 25% new cases and 15% of all cancer cases death amongst women, In India the age adjusted rate of breast cancer is as high as 25. 8…”

Section: Overall Burdenmentioning

confidence: 99%

Cancer (Sartan) amongst women and its preventive approach in Unani system of medicine

Anjum

2019

J. Drug Delivery Ther.

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Cancer has been defined as, malignant growth characterized by the uninhibited proliferation of cells, often affecting healthy tissues locally or throughout the body. Cancer is not a new disease some of the cancers that most often affect women are breast, colon, endometrial, lung, cervical, skin, and ovarian cancers. The most significant risk factor for cancer is age; two-thirds of all cases were in those older than age 65 years, Owing to its high incidence in nature, it is the second leading cause of death after cardiovascular aetiology. Unani or Greek-o-Arab medicine originated in Greece about 2500 years back and is based upon the four humours theory, Unani scholars believed that the body contained four humours (Akhlaat) any imbalance of these fluids will result in disease and excess of black bile (Sauda) in a particular organ site was thought to cause cancer (Sartan). The world’s oldest recorded case of breast cancer hails from ancient Egypt in 1500 BC and it was recorded that there was no treatment for the cancer, only palliative treatment. According to inscriptions, surface tumours were surgically removed in a similar manner as they are removed today. So it is an effort through this paper to highlight the preventive measures mention in the classical Unani literature for cancer prevalent amongst females and some of the cancers can be prevented by avoiding the accumulation of abnormal humours inside the body. Keywords: Akhlaat, Sartan, Preventive measures, sauda

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Section: Overall Burdenmentioning

confidence: 99%

Cancer (Sartan) amongst women and its preventive approach in Unani system of medicine

Anjum

2019

J. Drug Delivery Ther.

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“…Primarily, OC is classified into three broad categories (based on the ovarian cells): − (i) surface epithelial cells (cells that can cover the ovary and its subtypes); (ii) germ cells, cells that become ova (OC subtypes include yolk sac tumor, immature teratoma, and dysgerminoma); and (iii) sex cord-stromal cells that can produce hormones (OC subtypes include malignant granulosa cells and Sertoli-Leydig cells). Among these, EOC comprises nearly 85–90% of all forms of OC cases, characterized by heterogeneity at the histopathological, clinical, and molecular levels .…”

Section: Introductionmentioning

confidence: 99%

“…There are numerous hypotheses on the occurrence of OC among women, including those that can attribute the disease to incessant ovulation, gonadotropin-based stimulation, inflammation, and hormonal factors. Based on their clinical behavior, each of these is further subdivided into three groups: benign, malignant, and intermediate (low malignancy potential or borderline tumor) . Nearly 70% of high-grade OC patients respond satisfactorily to the chemotherapy, but unfortunately, most of them develop chemotherapy resistance, leading to treatment failure.…”

Section: Introductionmentioning

confidence: 99%

“…Based on their clinical behavior, each of these is further subdivided into three groups: benign, malignant, and intermediate (low malignancy potential or borderline tumor). 5 Nearly 70% of high-grade OC patients respond satisfactorily to the chemotherapy, but unfortunately, most of them develop chemotherapy resistance, leading to treatment failure. According to the SEER registry and other studies, the 10 year survival rate for all OC is approximately 30−40%, while the long-term survival of patients with high-grade serous carcinoma is low.…”

Section: Introductionmentioning

confidence: 99%

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Biomarkers for Early Diagnosis of Ovarian Carcinoma

Manasa¹,

Mascarenhas²,

Shetti

et al. 2022

ACS Biomater. Sci. Eng.

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The leading cause of gynecological cancer-related morbidity and mortality is ovarian cancer (OC), which is dubbed a silent killer. Currently, OC is a target of intense biomarker research, because it is often not discovered until the disease is advanced. The goal of OC research is to develop effective tests using biomarkers that can detect the disease at the earliest stages, which would eventually decrease the mortality, thereby preventing recurrence. Therefore, there is a pressing need to revisit the existing biomarkers to recognize the potential biomarkers that can lead to efficient predictors for the OC diagnosis. This Perspective covers an update on the currently available biomarkers used in the triaging of OC to gain certain insights into the potential role of these biomarkers and their estimation that are crucial to the understanding of neoplasm progression, diagnostics, and therapy.

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“…In the United States alone, 22 440 new ovarian cancer cases were recorded in 2017 . In India, the expected numbers of cases for ovarian cancer during 2015 and 2020 are 45 231 and 59 276, respectively . The majority of cancers are associated with mutated p53 protein, a loss of function mutation. , P53 protein is generally known as a tumor suppressor protein that regulates the cell cycle and works as a guardian of the genome. , Mutation in the p53 protein is the main cause of ovarian malignancies .…”

Section: Introductionmentioning

confidence: 99%

Restoration of p53 Function in Ovarian Cancer Mediated by Gold Nanoparticle-Based EGFR Targeted Gene Delivery System

Kotcherlakota

Vydiam

Srinivasan

et al. 2019

ACS Biomater. Sci. Eng.

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Targeted gene delivery of wild type tumor suppressor gene p53 is a promising approach to inhibit the progression of ovarian cancer. Although several gene delivery vehicles have been reported earlier, there is paucity for targeted delivery of wild type p53 to ovarian cancer using gold nanoparticles. As it is well-known that EGFR (epidermal growth factor receptor) is overexpressed in ovarian cancer, in this study we hypothesized that the FDA approved monoclonal antibody C225 (cetuximab) that targets EGFR could be used for targeted delivery of wild type p53 gene. With this impetus, we devised an approach wherein cationic gold nanoparticles (AuNPs) were employed to generate gold nanoparticle-based drug delivery system (DDS, Au-C225-p53DNA where p53DNA is pCMVp53 plasmid) that was formulated and characterized by biochemical and biophysical methods. The nanoconjugate complexed with DNA (Au-C225-p53DNA) is serum-stable and protects the bound DNA from digestion by DNase-I. Additionally, in vitro reporter gene expression assays demonstrated efficient and specific gene transfection in EGFR overexpressing SK-OV-3 cells. Further, the intraperitoneal administration of Au-C225-p53DNA in SK-OV-3 xenograft mouse model displayed significant tumor targeting and tumor regression. Altogether, these studies indicated a promising nanoparticle-based approach for targeting ovarian cancers caused by mutated p53.

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Ovarian carcinoma: An overview of current status

Cited by 4 publications

References 85 publications

Cancer (Sartan) amongst women and its preventive approach in Unani system of medicine

Cancer (Sartan) amongst women and its preventive approach in Unani system of medicine

Biomarkers for Early Diagnosis of Ovarian Carcinoma

Restoration of p53 Function in Ovarian Cancer Mediated by Gold Nanoparticle-Based EGFR Targeted Gene Delivery System

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