A case of clear cell carcinoma arising in extragonadal endometriosis

Abstract

Malignancy developing in extragonadal endometriosis is rare with the majority of cases being endometrioid adenocarcinomas. We present a 54-year-old woman who developed a clear cell carcinoma in her perineum, 25 years after excision of a perineal endometrioma in an episiotomy scar. Treatment involved radiotherapy and surgery, with a view to preserving vaginal function. Where benign extragonadal endometriosis occurs, the potential for malignant transformation persists even years after primary treatment.

Exclusive nodal recurrence after treatment of degenerated parietal endometriosis

“…Todd et al (6) described 11 cases of CCC arising in extraovarian endometriotic lesions, of which two were at episiotomy scars and one was at a cesarean section scar. We were able to find 19 cases of pure parietal lesions reported in the literature, and their histologic types are presented in Table 1 (63% CCC, 16% EC, and 21% mixed tumors) (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24).…”

Mixed Clear Cell and Endometrioid Carcinoma Arising in Parietal Endometriosis

“…Todd et al [5] reported 11 cases of clear cell carcinomas arising from extraovarian endometriosis; two of these carcinomas were from an episiotomy and one from a cesarean section scar. To our knowledge, the presence of both carcinoma types at a single endometriosis site is an exception.…”

Endoanal ultrasonography in the diagnosis and operative management of perianal endometriosis: report of two cases

“…Only surgery can provide the histologic specimens required to rule out the rare development of malignancy in patients with extragenital endometriosis [8].…”