Enantioselective resolution of chiral drugs using BSA functionalized magnetic nanoparticles

Fu, Yan; Huang, Tiantian; Chen, Bin; Shen, Jue; Duan, Xingwu; Zhang, Jinli; Li, Wei

doi:10.1016/j.seppur.2013.01.007

Cited by 59 publications

(42 citation statements)

References 44 publications

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“…Thus, it has been a promising alternative to conventional chemotherapy for the treatment of cancer [1][2][3]. Generally, due to the easy agglomeration and oxidation and the limited functional groups of magnetite nanoparticles [4], a suitable material coating, such as silica [5], chitosan [6], poly ε-caprolactone(PCL) [7], poly(ethyl-2-cyanoacrylate) (PECA) [8], bovine serum albumin (BSA) [9] and so on, is always necessary to improve these situations and is of significance for applications. However, to the best of our knowledge, the saturation magnetization (Ms) value of the drug loaded polymer-magnetic composition reported in literature, is much lower than the corresponding bare magnetic nanoparticles due to the formation of a non-magnetic shell.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization

et al. 2013

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“…The applications of new materials in different sample preparation techniques have been introduced in some recently published papers. Despite this application is out of the scope of this review, it is noteworthy to mention some investigations that showed different strategies for selective enantioseparations of chiral drugs by using chiral imprinted polymers as coatings for stir bar sorptive extraction devices , magnetic NPs functionalised with BSA and magnetic molecularly imprinted mesoporous silicas .…”

Section: Chiral Analysis By Miniaturised Liquid Phase Separation Techmentioning

confidence: 99%

Approaches for enantioselective resolution of pharmaceuticals by miniaturised separation techniques with new chiral phases based on nanoparticles and monolithis

et al. 2016

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This article discusses new developments in the preparation of nanoparticles and monoliths with emphasis upon their application as the stationary and pseudo-stationary phases for miniaturised liquid phase separation techniques, which have occurred in the last 10 years (from 2006 to the actuality). References included in this review represent current trends and state of the art in the application of these materials to the analysis, by EKC, CEC and miniaturised chromatography, of chiral compounds with environmental interest such as pharmaceuticals. Due to their extraordinary properties, columns prepared with these new chiral stationary or pseudo-stationary phases, based on materials such as gold nanoparticles, metal-organic frameworks, ordered mesoporous silicas, carbonaceous materials, polymeric-based and silica-based monoliths or molecularly imprinted materials, can usually show some improvements in the separation selectivity, column efficiency and chemical stability in comparison with conventional chiral columns available commercially.

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“…With bovine serum albumin (BSA) anchored on the surface of Fe 3 O 4 particles, Li et al. synthesized magnetic chiral adsorbent which demonstrated the ability for chiral recognition of ibuprofen and ofloxacin enantiomers . However, multistep operations and harsh reaction conditions (specific organic solvent or higher temperature) are usually required in the preparation process.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis and application of teicoplanin‐modified magnetic microparticles for enantioseparation

et al. 2017

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A facile, mild method for the preparation of teicoplanin (TE) modified Fe O microparticles (MPs) employing polydopamine (PDA) layer as a versatile secondary reaction platform was developed. The synthesized magnetic MPs (Fe O @PDA@TE) were characterized by various characterization techniques, such as TEM, zeta potential etc, to affirm the successful modification of TE to magnetic Fe O MPs. Using the as-synthesized materials as chiral adsorbents, efficient chiral separation of representative racemic compounds was successfully achieved. Due to the magnetic responsivity, the materials were easily isolated from the racemic solutions under an external magnetic field and could be readily reused for at least three times. Thus, the well-prepared functional magnetic MPs have great potential in preparative chiral separation.

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Enantioselective resolution of chiral drugs using BSA functionalized magnetic nanoparticles

Cited by 59 publications

References 44 publications

Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization

Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization

Approaches for enantioselective resolution of pharmaceuticals by miniaturised separation techniques with new chiral phases based on nanoparticles and monolithis

Facile synthesis and application of teicoplanin‐modified magnetic microparticles for enantioseparation

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