Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization

Chen, Fenghua; Zhao, Taonan; Chen, Qingtao; Han, Lifeng; Fang, Shaoming; Chen, Zhijun

doi:10.1016/j.matlet.2013.06.108

Cited by 19 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results clearly proved the ability of DC to control the MTX release over time, and are consistent with literature data evaluating the drug delivery performance of nanoparticle systems [34,35].…”

Section: Drug Release Experimentssupporting

confidence: 89%

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

et al. 2019

View full text Add to dashboard Cite

With the aim to effectively deliver methotrexate (MTX) to breast cancer cells, we designed a nanocarrier system (DC) derived from the self-assembly of a dextran-curcumin conjugate prepared via enzyme chemistry with immobilized laccase acting as a solid biocatalyst. Nanoparticles consisted of homogeneously dispersed nanospheres with a mean diameter of 290 nm, as characterized by combined transmission electron microscopy and dynamic light scattering investigations. DC was able to control the MTX release overtime (t1/2 value of 310 min), with cell internalization studies proving its presence inside MCF-7 cytoplasm. Finally, improved MTX efficacy was obtained in viability assays, and attributed to the synergy of curcumin moieties and loaded MTX as underlined by a combination index (CI) < 1.

show abstract

Section: Drug Release Experimentssupporting

confidence: 89%

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The nanofiber mats exhibited all the functional groups vibrations with shifting of bands from pure 5Fu and PLA spectrum. The shifting of the bands by the incorporation of 5Fu, Fe 3 O 4 , MC, and PEG into the PLA mats are due to (i) hydrogen bonding between the −NH of 5Fu and CO of PLA, (ii) coordination bonding between the 5Fu, Fe 3 O 4 and PLA, and (iii) the occurrence of hydrogen and weak chelating bonding between the molecules, as shown in Scheme .…”

Section: Resultsmentioning

confidence: 98%

“…Besides several metal oxides, Fe 3 O 4 nanoparticles are considered as one of the promising materials to be used as MRI contrast agents, tissue repair, hyperthermia, and carriers for targeted drug delivery. It could support chemotherapy along with the drugs by generating reactive oxygen species that directly damages DNA, proteins, and lipid molecules of the cancer cells. , In order to reduce the risk of nanoparticles in damaging the healthy tissues, hydrophilic and natural polymers such as polyethylene glycol and methylcellulose can be used as capping agents . Methylcellulose (MC) is nonimmunogenic, safe, and proven biomaterial that has been approved by the Food and Drug Administration (FDA), mostly used as a mucosal protectant to restrict the mucosal toxicity that occurs because of chemotherapy. − Polyethylene glycol (PEG) is found to be a well-recognized FDA-approved hydrophilic polymer that is largely used in drug delivery due to its nontoxicity, as well as its nonimmunogenic, bioinert, highly bioavailable, and solubility properties .…”

Section: Introductionmentioning

confidence: 99%

Nanofibers Embedded with Nanoparticles as Carriers for the Controlled Release of Anticancer Drug: Promoting the Apoptosis of Breast Cancer Cell Line and Growth Inhibition of Microbial Strains

Jaisankar,

Azarudeen,

Thirumarimurugan

2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

The polymeric nanofiber mats were produced from polylactic acid, methylcellulose, and polyethylene glycol with 5fluorouracil (5Fu) drug and iron oxide (Fe 3 O 4 ) nanoparticles. Spectral and crystallographic studies clearly elucidated the ionic interactions, structure and nature of the mats. Fe 3 O 4 nanoparticles <10 nm in size, along with methyl cellulose and polyethylene glycol, have significantly reduced the size of nanofiber mats. The mechanical properties for the mats was found to be challenging; however, surface wettability, swelling capacity, and drug encapsulation efficiency results were promising. A controlled drug release pattern was observed from in vitro drug release study, zero-order kinetics, and a Higuchi model. Nanofiber mats showed higher anticancer activity (78%) against MDA-MB 231 cancer cells, which reveals that a small amount of 5Fu drug (15.86%) with high levels of O 2 ••, H 2 O 2 , and OH • radicals generated from Fe 3 O 4 have catalyzed the Fenton's reaction to eradicate the cancer cells, in a shorter span of 24 h, itself. In addition, the apoptosis assay by dual AO/PI staining method clearly exhibited the apoptotic cancer cells by fluorescence microscopy. Incorporation of Fe 3 O 4 nanoparticles enhanced the anticancer activity of the mats, compared to the commercially available standard 5Fu drug. Nanofiber mats significantly controlled the growth of selected pathogenic microbial strains by the action of the 5Fu drug and Fe 3+ ions. The degradation of mats was investigated by an in vitro mass loss study for a period of 360 days. In a nutshell, promising nanofiber mats were produced as targeted drug delivery devices for chemotherapy.

show abstract

“…The stretching vibrations at B3269 and 842 cm À1 and the bending vibration at B1585 cm À1 are assigned to the N-H bond. 5,33,34 The stretching vibrations of the C-H bond occur at B2936 and 2882 cm À1 . 33 The absorption at B1390 cm À1 is assigned to the CQO stretching vibration.…”

Section: Analysis Of the Morphology And Structure Of Polymer-like Coated Osinpsmentioning

confidence: 99%

Facile synthesis of solid-state fluorescent organosilica nanoparticles with a photoluminescence quantum yield of 73.3% for fingerprint recognition and white-light-emitting diodes

Liang

Gong

et al. 2021

J. Mater. Chem. C

View full text Add to dashboard Cite

show abstract

Synthesis and release behavior of methotrexate from Fe3O4/PLA–PEG core/shell nanoparticles with high saturation magnetization

Cited by 19 publications

References 15 publications

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

Nanofibers Embedded with Nanoparticles as Carriers for the Controlled Release of Anticancer Drug: Promoting the Apoptosis of Breast Cancer Cell Line and Growth Inhibition of Microbial Strains

Facile synthesis of solid-state fluorescent organosilica nanoparticles with a photoluminescence quantum yield of 73.3% for fingerprint recognition and white-light-emitting diodes

Contact Info

Product

Resources

About