Approaches for enantioselective resolution of pharmaceuticals by miniaturised separation techniques with new chiral phases based on nanoparticles and monolithis

Sierra, Isabel; Marina, Marı́a Luisa; Pérez‐Quintanilla, Damián; Morante‐Zarcero, Sonia; Silva, Mariana

doi:10.1002/elps.201600131

Cited by 16 publications

(9 citation statements)

References 76 publications

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“…Several reviews have been devoted to molecularly-imprinted CSPs, mainly focusing on their developments and the different fields of application [45,88,246,247,248,249,250,251,252,253]. Although the developments concerning this type of CSPs are becoming more usual, their enantioresolution performance is currently not competitive in comparison to the existing CSPs.…”

Section: Chiral Stationary Phases: Recent Developmentsmentioning

confidence: 99%

Chiral Stationary Phases for Liquid Chromatography: Recent Developments

et al. 2019

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The planning and development of new chiral stationary phases (CSPs) for liquid chromatography (LC) are considered as continuous and evolutionary issues since the introduction of the first CSP in 1938. The main objectives of the development strategies were to attempt the improvement of the chromatographic enantioresolution performance of the CSPs as well as enlarge their versatility and range of applications. Additionally, the transition to ultra-high-performance LC were underscored. The most recent strategies have comprised the introduction of new chiral selectors, the use of new materials as chromatographic supports or the reduction of its particle size, and the application of different synthetic approaches for preparation of CSPs. This review gathered the most recent developments associated to the different types of CSPs providing an overview of the relevant advances that are arising on LC.

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Section: Chiral Stationary Phases: Recent Developmentsmentioning

confidence: 99%

Chiral Stationary Phases for Liquid Chromatography: Recent Developments

et al. 2019

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“…Furthermore, organic-silica hybrid monoliths are of interest for MIP implementation as the integrity of the template cavities is kept mostly intact and the template removal is more straightforward [243]. To date, the best separation efficiency has been observed with OT-CEC columns [250]. The further development of MIP columns is therefore expected to go alongside advances in the field of OT-CEC.…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Past, present, and future developments in enantioselective analysis using capillary electromigration techniques

2020

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Past, present, and future developments in enantioselective analysis using capillary electromigration techniques Enantioseparation of chiral products has become increasingly important in a large diversity of academic and industrial applications. The separation of chiral compounds is inherently challenging and thus requires a suitable analytical technique that can achieve high resolution and sensitivity. In this context, CE has shown remarkable results so far. Chiral CE offers an orthogonal enantioselectivity and is typically considered less costly than chromatographic techniques, since only minute amounts of chiral selectors are needed. Several CE approaches have been developed for chiral analysis, including chiral EKC and chiral CEC. Enantioseparations by EKC benefit from the wide variety of possible pseudostationary phases that can be employed. Chiral CEC, on the other hand, combines chromatographic separation principles with the bulk fluid movement of CE, benefitting from reduced band broadening as compared to pressure-driven systems. Although UV detection is conventionally used for these approaches, MS can also be considered. CE-MS represents a promising alternative due to the increased sensitivity and selectivity, enabling the chiral analysis of complex samples. The potential contamination of the MS ion source in EKC-MS can be overcome using partial-filling and counter-migration techniques. However, chiral analysis using monolithic and open-tubular CEC-MS awaits additional method validation and a dedicated commercial interface. Further efforts in chiral CE are expected toward the improvement of existing techniques, the development of novel pseudostationary phases, and establishing the use of chiral ionic liquids, molecular imprinted polymers, and metalorganic frameworks. These developments will certainly foster the adoption of CE(-MS) as a well-established technique in routine chiral analysis.

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“…However, nanoLC is not limited to "omics", and has furthermore become of increasing interest for e.g. enantiomer separations 7,8 . Due to nanoLC´s compatibility with limited sample amounts, emerging bio-applications include single-cell analyses and increasing focuses on clinical analysis.…”

Section: Introductionmentioning

confidence: 99%