Facile synthesis and application of teicoplanin‐modified magnetic microparticles for enantioseparation

Abstract

A facile, mild method for the preparation of teicoplanin (TE) modified Fe O microparticles (MPs) employing polydopamine (PDA) layer as a versatile secondary reaction platform was developed. The synthesized magnetic MPs (Fe O @PDA@TE) were characterized by various characterization techniques, such as TEM, zeta potential etc, to affirm the successful modification of TE to magnetic Fe O MPs. Using the as-synthesized materials as chiral adsorbents, efficient chiral separation of representative racemic compounds was successfully achieved. Due to the magnetic responsivity, the materials were easily isolated from the racemic solutions under an external magnetic field and could be readily reused for at least three times. Thus, the well-prepared functional magnetic MPs have great potential in preparative chiral separation.

Recent advances in nanomaterial‐based capillary electrophoresis

“…Efficient chiral separation of racemic compounds was successfully achieved. Due to the magnetic responsively, the materials were easily isolated from the racemic solutions under an external magnetic field . Recently, CE‐based determination and separation of antidepressant from human urine was developed using poly(styrene‐co‐divinylbenzene)‐coated magnetic multiwalled carbon nanotube (MMWCNT) composite.…”

Applications of polydopamine modifications in capillary electrophoretic analysis

“…Although the prepared chiral adsorbents exhibited good stability, the adsorption process was tedious. Therefore, Wang et al [40] proposed to simplify the adsorption process by preparing a teicoplanin-modified Fe 3 O 4 microparticles employing PDA as an intermediate layer to study the chiral recognition ability of teicoplanin in chiral separating the aromatic amino acids. The separation process is greatly simplified as the magnetic responsivity was incorporated.…”

Novel Smart Polymer-Brush-Modified Magnetic Graphene Oxide for Highly Efficient Chiral Recognition and Enantioseparation of Tryptophan Enantiomers

“…Therefore, it is highly desirable to carry out effective chiral identification and enantioseparation of AA enantiomers. To date, several technologies including chromatography, electromigration, membrane separation, , and nanomaterials-based adsorption ,− have been utilized to recognize and separate AA enantiomers. Among them, nanomaterials-based adsorption is a competitive technology to discriminate and separate AA enantiomers because of its operational simplicity, time savings, and low cost. ,− The crucial point of this technique is to develop high-performance nanoselectors.…”

“…Chiral magnetic nanoparticles (NPs) are one type of newly emerging nanoselectors from the past several years. They were obtained through surface modification of magnetic NPs with various chiral molecules like cellulose derivatives, , macrocyclic antibiotics, , proteins, , polysaccharide or its derivatives, ,− and so on . Several research groups have developed a large number of magnetic nanoselectors through surface decoration of Fe 3 O 4 or silica-coated Fe 3 O 4 NPs with numerous chiral molecules, such as macrocyclic teicoplanin, , bovine serum albumin (BSA), human serum albumin (HSA), and β-cyclodextrin (β-CD) or its derivatives, ,− and investigated their enantioselectivity and separation performances toward AA enantiomers.…”

“…They were obtained through surface modification of magnetic NPs with various chiral molecules like cellulose derivatives, , macrocyclic antibiotics, , proteins, , polysaccharide or its derivatives, ,− and so on . Several research groups have developed a large number of magnetic nanoselectors through surface decoration of Fe 3 O 4 or silica-coated Fe 3 O 4 NPs with numerous chiral molecules, such as macrocyclic teicoplanin, , bovine serum albumin (BSA), human serum albumin (HSA), and β-cyclodextrin (β-CD) or its derivatives, ,− and investigated their enantioselectivity and separation performances toward AA enantiomers. Although those magnetic nanoselectors display excellent enantioselectivity toward L -enantiomers over D -enantiomers and can be utilized in direct chiral identification and enantioseparation of AA enantiomers.…”