Recent advances in nanomaterial‐based capillary electrophoresis

Kitte, Shimeles Addisu; Fereja, Tadesse Haile; Halawa, Mohamed Ibrahim; Lou, Baohua; Li, Haijuan; Xu, Guobao

doi:10.1002/elps.201800534

Cited by 21 publications

(5 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This concept has been extensively reviewed considering the material used [436][437][438][439][440] or the target analytes (i.e., parabens [441], peptides [442], natural products [443], drugs of abuse [444], pollutants [445], organic acids [435],…”

Section: Passive Sample Pretreatment Stepsmentioning

confidence: 99%

“…One of the simplest (and most widely used) sample pretreatment procedures (for clean‐up and preconcentration) prior to CE is off‐line solid‐phase extraction (SPE). This concept has been extensively reviewed considering the material used [436–440] or the target analytes (i.e., parabens [441], peptides [442], natural products [443], drugs of abuse [444], pollutants [445], organic acids [435], or oligonucleotides [446]). Beyond the use of non‐specific hydrophobic (C 18 [447] or carbon‐based materials [165, 448]) or electrostatic interactions [449, 450], perhaps the most significant advancements reported involve the use of much smaller volumes (typically just a few µL) of both sample and elution [451] and the application of custom materials [452] that can give some selectivity prior to the separation.…”

Section: Direct Injection Sample Pretreatment and Preconcentrationmentioning

confidence: 99%

See 1 more Smart Citation

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

et al. 2023

View full text Add to dashboard Cite

This review is in support of the development of selective, precise, fast, and validated capillary electrophoresis (CE) methods. It follows up a similar article from 1998, Wätzig H, Degenhardt M, Kunkel A. “Strategies for capillary electrophoresis: method development and validation for pharmaceutical and biological applications,” pointing out which fundamentals are still valid and at the same time showing the enormous achievements in the last 25 years. The structures of both reviews are widely similar, in order to facilitate their simultaneous use. Focusing on pharmaceutical and biological applications, the successful use of CE is now demonstrated by more than 600 carefully selected references. Many of those are recent reviews; therefore, a significant overview about the field is provided. There are extra sections about sample pretreatment related to CE and microchip CE, and a completely revised section about method development for protein analytes and biomolecules in general. The general strategies for method development are summed up with regard to selectivity, efficiency, precision, analysis time, limit of detection, sample pretreatment requirements, and validation.

show abstract

Section: Passive Sample Pretreatment Stepsmentioning

confidence: 99%

Section: Direct Injection Sample Pretreatment and Preconcentrationmentioning

confidence: 99%

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The separation properties of CEC are mainly attributed to the noncovalent interactions between analytes and the stationary phase, including hydrophobic, hydrophilic, electron donor-acceptor interaction and size exclusion [3,4]. Development of novel chiral-stationary phases for chiral CEC is an eternal research subject either in chemical industry or pharmaceutical production [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

β‐Cyclodextrin covalent organic framework supported by polydopamine as stationary phases for electrochromatographic enantioseparation

Guan

Huang

et al. 2022

Electrophoresis

View full text Add to dashboard Cite

In this work, a new open‐tubular capillary electrochromatography (OT‐CEC) column was prepared using β‐cyclodextrin covalent organic framework (β‐CD COF) as a stationary phase. Polydopamine was used to assist fabrication of β‐CD COF on an inner wall of a fused‐silica capillary. The coating layer on the capillary was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Electroosmotic flow (EOF) was also studied to evaluate the variation of the inner wall of immobilized columns. Furthermore, the chiral separation effectiveness of the fabricated capillary column was evaluated by CEC using enantiomers of several related proton pump inhibitors as model analytes, including omeprazole, lansoprazole, pantoprazole and tenatoprazole. The effects of bonding time and concentration of β‐CD COF, the type, concentration and pH of buffer, applied voltage were investigated to obtain satisfactory enantioselectivity. In the optimum conditions, the enantiomers of four analytes were resolved within 15 min with resolutions of 1.63–2.62. The relative standard deviation values for migration times and resolutions of the analytes representing intraday and interday were less than 6.75% and 4.24%, respectively. The results reveal that β‐CD COF has great potential as chiral‐stationary phases for enantioseparation in CEC.

show abstract

“…Production of composite materials with specified dielectric properties is an important task in many fields, including production of protective dielectric layers in various electronic devices, supercondensers, as well as functional layers of sorbents, which increase efficiency of electrophoretic separation of components in capillary columns and microfluidic chips [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Dielectric properties of oligomeric diisocyanate based composites with barium titanate

Mjakin

Bubis

Kuznetsov

et al. 2022

Physics of the Solid State

View full text Add to dashboard Cite

A series of composites is synthesized on the basis of oligomeric diisocyanate with different contents of ferroelectric filler barium titanate (BaTiO3). The dielectric performances of the obtained composites are found to follow extreme dependences on the filler content with a sharp minimum of the dielectric permittivity and maximum of the dielectric loss tangent at BaTiO3 content 30 vol.%. The characterization of the composite layers by confocal microscopy revealed that the observed dependences of their dielectric properties upon the composition are determined by structural changes of the composites, including percolation, formation of a single infinite cluster and structures of matrix-island and chain types at certain critical concentrations. Keywords: composites, coatings, diisocyanate, barium titanate, dielectric permittivity, dielectric loss, electrochromatography, supercapacitors.

show abstract

Recent advances in nanomaterial‐based capillary electrophoresis

Cited by 21 publications

References 75 publications

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition

β‐Cyclodextrin covalent organic framework supported by polydopamine as stationary phases for electrochromatographic enantioseparation

Dielectric properties of oligomeric diisocyanate based composites with barium titanate

Contact Info

Product

Resources

About