The most commons woods used for production of medium density particleboard (MDP) are Eucalyptus and Pinus. The Cajueiro and Amescla wood are typical trees coming from the center-west of Brazil, from the States of Mato Grosso and Tocatins. These are medium density woods similar to Pinus sp, the Brazilian's wood's industries usually used these woods only as piece of wood for structures or furniture. The purpose of this research is to investigate, in a preliminary study, the possibility of MDP panel's production using Cajueiro and Amescla wood species. The panels were produced under a pressure of 4 MPa for 10 minutes at 100°C, and it was produced a total of 12 MDP panels, 6 of Cajueiro and 6 of Amescla, with a thickness of 10mm, dimensions 250mm×250mm and 0.5 kg mass. For the bending modulus of elasticity, 2200 MPa were obtained for Cajueiro and 2700 MPa for Amescla, which are considered good values. The results can be considered satisfactory because it is a preliminary and unpublished study in the case of MDP panels manufactured with Cajueiro and Amescla wood species.