Emergence of methicillin-resistant Staphylococcus aureus from clonal complex 398 with no livestock association in Brazil

Abstract

CC398 is a livestock-associated Staphylococcus aureus. However, it has also been isolated from humans with no previous contact with livestock. A surveillance of methicillin-resistant S. aureus colonisation among children attending public day care centres and hospitals in Niterói and Rio de Janeiro, Brazil, between 2011 and 2013, resulted in the isolation of six cases of CC398 from individuals with no previous exposure to livestock. These isolates showed a high frequency of the erm(C) gene (4/6, 66.7%) with induced resistance to clindamycin, and a relatively high frequency of SEs and lukS/lukF genes. These results suggest the emergence of a non-LA-CC398 in Brazil.

Insights into the epidemiology of community-associated methicillin-resistant Staphylococcus aureus in special populations and at the community-healthcare interface

“…The genes encoding PVL were detected in these isolates. 67 These findings indicate that the ST398 clone might be emerging in the community in different parts of the country and in different population groups, with this occurrence being underreported, as suggested by Neto et al. 67 …”

Prevalence of methicillin-resistant Staphylococcus aureus colonization among healthcare workers at a tertiary care hospital in northeastern Brazil

“…In this study, one sample presented ST 1232, which belongs to CC 398, being one of the most important clones of S. aureus associated with cattle, and contact with these animals represents a risk factor for human colonization [ 46 ]. However, a study carried out in Rio de Janeiro with 1,852 children identified 6 CC398 bacterial isolates, and the individuals did not have previous contact with animals, suggesting that the transmission of this clone can occur routinely in urban areas regardless of previous exposure [ 47 ]. The distribution of complexes between different environments highlights the importance of developing preventive measures in the control of bacterial transmission [ 48 ].…”

First report of meticillin-resistant Staphylococcus aureus harboring mecC gene in milk samples from cows with mastitis in southeastern Brazil

“…Yet, all MRSA isolates from these studies carried the mecA gene, while in our study, ST97 harboring mecC was for the first time identified. In Brazil, only few studies reported MRSA ST398 [25,26], ST126, and ST133 [27]. Besides ST97, we identified mecC in a ST746 strain, and to the best of our knowledge, a mecC ST746 has never been reported before.…”