Insights into the epidemiology of community-associated methicillin-resistant Staphylococcus aureus in special populations and at the community-healthcare interface

Romero, Letícia Calixto; Cunha, Maria de Lourdes Ribeiro de Souza da

doi:10.1016/j.bjid.2021.101636

Cited by 23 publications

(16 citation statements)

References 79 publications

(111 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study found a high prevalence of CA-MRSA infections, most of which were related to skin infections. CA-MRSA have been described as causing severe infections, usually pneumonia and skin and soft tissue infections in individuals not exposed to healthcare settings [ 18 ]. While in some regions of the world MRSA remains mostly an HA and HCA pathogen, in others it has become endemic in the community, and in Latin America, it is an increasing problem [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and risk factors for mortality among methicillin-resistant Staphylococcus aureus bacteremic patients in Southern Brazil

Riche

Cassol²,

Falci³

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

This study aimed to evaluate the epidemiology and 30-day mortality of adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. We retrospectively reviewed the demographic and clinical data of adult patients with S. aureus bloodstream infections (BSI), admitted to a tertiary public teaching medical center in Porto Alegre, Southern Brazil, from January 2014 to December 2019. A total of 928 patients with S. aureus BSI were identified in the study period (68.5 per 100,000 patient-years), and the proportion of MRSA isolates was 22% (19–27%). Thus, 199 patients were included in the analyses. The median age was 62 (IQR: 51–74) years, Charlson Comorbidity Index (CCI) median was 5 (IQR: 3–6), the Pitt bacteremia score (PBS) median was 1 (IQR: 1–4), and the most common site of infection was skin and soft tissue (26%). Most infections were hospital-acquired (54%), empirical anti-MRSA treatment was initiated in 34% of the cases, and in 44% vancomycin minimum inhibitory concentration was 1.5mg/L or above. Sixty-two (31.2%) patients died up to 30 days after the bacteremia episode. Patients with more comorbid conditions (higher CCI; aOR 1.222, p = 0.006) and a more severe presentation (higher PBS; aOR 1.726, p<0.001) were independently associated with mortality. Empiric antimicrobial therapy with an anti-MRSA regimen was associated with reduced mortality (aOR 0.319, p = 0.016). Our study identified significant risk factors for 30-day mortality in patients with MRSA BSI in a population with a high incidence of S. aureus bacteremia. Empiric treatment with an anti-MRSA drug was a protective factor. No significant variation in the incidence of S. aureus BSI was recorded throughout the period.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiology and risk factors for mortality among methicillin-resistant Staphylococcus aureus bacteremic patients in Southern Brazil

Riche

Cassol²,

Falci³

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Their average age was 4.4 years (range of 2 to 9 years). The cats had an average of 4.3 years (range of 2 to 8 years), and most of them were domestic short hairs (41), domestic long hairs (18) and a Siamese (1).…”

Section: Study Populationmentioning

confidence: 99%

“…For decades, S. aureus has been considered the most important pathogen of the genus [14][15][16][17]. In people, it can be found in community settings [18] or hospital premises, constituting an important source of infections associated with healthcare [19]. The bacterium can produce infections in humans associated with skin and soft tissue, pneumonia, septicemia and osteomyelitis [19], which have also been reported in animals [20].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Staphylococcus Species Obtained from Healthy Companion Animals and Humans

Thomson

García

Miles

et al. 2022

Veterinary Sciences

View full text Add to dashboard Cite

The close contact between people and their pets has generated the exchange of skin microbiota, accompanied by bacteria that present resistance to antibiotics. Staphylococcus spp., opportunistic pathogens present in the skin and mucosa of mammals, have had their importance recognized in human and veterinary medicine. The objectives of this study were to identify Staphylococcus spp. present in isolates from the nostrils of healthy humans, dogs and cats as well as to determine their phenotype of resistance to methicillin. Strain identification was performed by MALDI-TOF mass spectrometry and antimicrobial susceptibility was determined using a disk diffusion assay for 12 antibiotics. Sixty humans (veterinary and technicians), sixty dogs and sixty cats were sampled; of them, 61.6%, 56.6% and 46.6%, respectively, carried Staphylococcus spp. in their nostrils, and only two people carried two different species of Staphylococcus in the only anatomical site sampled. A methicillin-resistant phenotype was present in 48.7% of the humans, 26.5% of the dogs and 57.1% of the cats, and sampled. These results demonstrate the presence of Staphylococcus spp. strains resistant to methicillin in personnel who work in contact with animals, as well as in dogs and cats that entered the same hospital or veterinary clinic, which alerts us to the potential transfer of these strains to or between people, dogs and/or cats.

show abstract

“…E-mail: orlando.sousa@ufjf.br Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License and communities in different countries, methicillinresistant Staphylococcus aureus (MRSA), which causes meningitis and pneumonia, and Pseudomonas aeruginosa, which affects individuals with compromised immunity (AIDS, cancer, transplant or cystic fibrosis), have been a worldwide public health problem that needs new treatments (Reddy, 2022). Furthermore, from an epidemiological point of view, MRSA is constantly changing, and circulating clones and their antibiotic resistance profiles vary considerably by region and country (Romero and Cunha, 2021). Considering these aspects, natural products are one of the most promising sources of antibacterial agents that can be associated with antibiotics to enhance the therapeutic potential by inhibiting infectious mechanisms (Qadri et al, 2022;Ramata-Stunda et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antibiotic efficacy of Ocimum gratissimum L. essential oil against Staphylococcus aureus and Pseudomonas aeruginosa

Leonardo¹,

Flávia²,

Celia³

et al. 2023

J. Med. Plants Res.

View full text Add to dashboard Cite

Ocimum gratissimum essential oil (EOGT) has been evaluated for its antibacterial efficacy, and its combinational therapy with antibiotics may enhance the therapeutic efficiency against infectioncausing bacteria. Herein, we evaluated the chemical composition of EOGT and its antibiotic efficacy against Staphylococcus aureus and Pseudomonas aeruginosa. GC-MS and GC-FID analyzed EOGT. The antibiotic efficacy was determined by the agar diffusion method, microdilution, minimum inhibitory concentration (MIC), and fractional inhibitory concentration index (FICI). Eugenol (74.2%) was the main component of OGT. Using the agar diffusion method, the action of rifampicin, ciprofloxacin, and tetracycline was evaluated against S. aureus, while the action of cefepime and ciprofloxacin was evaluated against P. aeruginosa. FICI showed a reduced MIC of ciprofloxacin and tetracycline associated with EOGT. In the presence of EOGT, MIC of ciprofloxacin reduced from 0.6 to 0.0006 μg/mL and of tetracycline decreased from 0.028 to 0.0018 μg/mL against S. aureus and from 4 to 0.12 μg/mL against P. aeruginosa. EOGT enhanced the antibacterial efficacy of the antibiotics suggesting a synergistic effect, thereby enhancing the efficacy in treating infection against S. aureus and P. aeruginosa.

show abstract

Insights into the epidemiology of community-associated methicillin-resistant Staphylococcus aureus in special populations and at the community-healthcare interface

Cited by 23 publications

References 79 publications

Epidemiology and risk factors for mortality among methicillin-resistant Staphylococcus aureus bacteremic patients in Southern Brazil

Epidemiology and risk factors for mortality among methicillin-resistant Staphylococcus aureus bacteremic patients in Southern Brazil

Isolation and Identification of Staphylococcus Species Obtained from Healthy Companion Animals and Humans

Evaluation of antibiotic efficacy of Ocimum gratissimum L. essential oil against Staphylococcus aureus and Pseudomonas aeruginosa

Contact Info

Product

Resources

About