Ellagic acid ameliorates lung damage in rats via modulating antioxidant activities, inhibitory effects on inflammatory mediators and apoptosis-inducing activities

Aslan, Abdullah Nabi; Hussein, Yousif Taha; Gök, Özlem; Beyaz, Seda; Erman, Orhan; Başpınar, Serpil

doi:10.1007/s11356-019-07352-8

Cited by 40 publications

(19 citation statements)

References 75 publications

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“…During the process, ellagic acid dramatically inhibited production of inflammatory cytokines IL-1β, IL-6 and COX-2, as well as increased CAT, GSH and IL-10 expression. These effects were associated with its activation of caspase-3 as well as down-regulation of the Bcl-2/Bax and NF-κB signaling pathways [ 332 , 333 ].…”

Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

197

121

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Section: Natural Compounds That Exert Anti-ali Effectsmentioning

confidence: 99%

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Zhou

et al. 2021

Pharmacological Research

197

121

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“…However, when compared with the STZ group, caspase‐3 levels were increased and bcl‐2 protein levels were decreased in the kidney tissue of diabetic rats where CUR, C60, and their combinations were applied (Figure 1). It has been reported that caspase‐3 levels decreased in rats where toxic compounds were administered and caspase‐3 levels increased in tissue as a result of therapeutic phytochemicals (Aslan et al., 2020). CUR has been reported to weaken in vitro high glucose‐induced podocyte apoptosis and in vivo diabetic nephropathy due to its strong antioxidant properties (Sun, Liu, Chen, Guan, & Liu, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…SDS‐PAGE method was utilized and accordingly, the protein samples of this tissue were run on 12% of gel. These proteins (caspase‐3, bcl‐2, and beta‐actin) were then relocated to the nitrocellulose membrane in accordance with the western blotting method after which their synthesis ratios were examined (Aslan, Gok, Erman, & Kuloglu, 2018; Aslan et al., 2020; Laemmli, 1970). Density measurement analysis system (Image J; National Institute of Health, Bethesda, USA) was used afterward for determining the protein levels.…”

Section: Methodsmentioning

confidence: 99%

Protective effect of pristine C60 fullerene nanoparticle in combination with curcumin against hyperglycemia‐induced kidney damage in diabetes caused by streptozotocin

Demir

Aslan

2020

J. Food Biochem.

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Today, diabetes has become a significant metabolic disease.Sedentary lifestyle and obesity increase the incidence of this disease. The International Diabetes Federation states that approximately 425 million people are affected from diabetes worldwide as of now, but by 2045, the number of patients is projected to exceed 600 million (Matoba et al., 2020).Diabetes develops due to deficiency of insulin secretion or decreased tissue sensitivity to insulin. It leads to complications such as uncontrolled hyperglycemia, diabetic nephropathy, cardiomyopathy, retinopathy in diabetic patients. Diabetic nephropathy is a common complication linked to type-1 and type-2 diabetes, with end-term kidney failure seen in almost 30% of individuals with diabetes (Chowdhury, Ghosh, Das, & Sil, 2019). There are numerous studies reporting that chronic hyperglycemia causes an increase in

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“…They have potent antioxidants, metabolic, and cardiovascular effects. They can inhibit the proliferation of lung cancer cells by increasing autophagy [97,98]. Resveratrol and ellagic acid may also help protect DNA and balance cell cycles.…”

Section: Plants and Phytochemicalsmentioning

confidence: 99%

Natural Antioxidants to the Rescue?

Aydin¹,

Seyidoğlu²

2021

Antioxidants - Benefits, Sources, Mechanisms of Action

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Natural antioxidant compounds have different mechanisms of treatment and prevention against various diseases due to their richest ingredients. There are several antioxidants used today, such as phytogenic ingredients, flavonoids, capsaicin, spirulina, beta-glucan, polyphenol etc. Besides the outbreak of diseases, the ability to scavenge oxidative conditions of the natural antioxidants have been notably important. Thereby, therapeutic strategies of diseases have been interested by researchers. Try to seek a kind of effects of natural antioxidants to various diseases, especially viral or pandemic diseases are being important nowadays. This chapter we’ll mention about how to viral or pandemic disease’s effects on oxidative status in both animals and humans, and what kind of phytochemical ingredients would be a positive effect on. At the same time, the latest advances about these natural antioxidant compounds and pharmaceuticals will be critically highlighted and discussed with newest literatures.

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Ellagic acid ameliorates lung damage in rats via modulating antioxidant activities, inhibitory effects on inflammatory mediators and apoptosis-inducing activities

Cited by 40 publications

References 75 publications

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Protective effect of pristine C60 fullerene nanoparticle in combination with curcumin against hyperglycemia‐induced kidney damage in diabetes caused by streptozotocin

Natural Antioxidants to the Rescue?

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