Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

He, Yu-Qiong; Zhou, Cancan; Yu, Luyao; Wang, Liang; Deng, Jiaming; Tao, Yulong; Zhang, Feng; Chen, Wansheng

doi:10.1016/j.phrs.2020.105224

Cited by 226 publications

(144 citation statements)

References 434 publications

(536 reference statements)

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“…Curcumin is a multipotential compound from C. longa that possesses diverse medicinal properties. It is a potent anti-inflammatory agent that is effective against numerous chronic diseases [ 14 , [440] , [441] , [442] , [443] ].…”

Section: Curcumin and Covid-19mentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

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Section: Curcumin and Covid-19mentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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“…Non-intoxicating CBD is a phytocannabinoid isolated from the Cannabis sativa plant [ 13 , 14 ] and, apart from the psychoactive ∆ 9 -tetrahydrocannabinol (THC), represents the best-studied compound in this group.…”

Section: Cannabidiol—pharmacological Potential and Mechanism Of Acmentioning

confidence: 99%

“…Nonetheless, the antiviral drug remdesivir shortens hospitalization time and the glucocorticoid dexamethasone even reduces mortality [ 10 , 11 ]. In addition, it is suggested that alternative compounds, including phytochemicals and natural agents targeting coronavirus development directly or as a result of their immunomodulatory effects, could be applied as potential therapies and for the prevention of COVID-19 [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19

Malinowska

Baranowska-Kuczko

Kicman

et al. 2021

IJMS

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to coronavirus disease 2019 (COVID-19) which, in turn, may be associated with multiple organ dysfunction. In this review, we present advantages and disadvantages of cannabidiol (CBD), a non-intoxicating phytocannabinoid from the cannabis plant, as a potential agent for the treatment of COVID-19. CBD has been shown to downregulate proteins responsible for viral entry and to inhibit SARS-CoV-2 replication. Preclinical studies have demonstrated its effectiveness against diseases of the respiratory system as well as its cardioprotective, nephroprotective, hepatoprotective, neuroprotective and anti-convulsant properties, that is, effects that may be beneficial for COVID-19. Only the latter two properties have been demonstrated in clinical studies, which also revealed anxiolytic and antinociceptive effects of CBD (given alone or together with Δ9-tetrahydrocannabinol), which may be important for an adjuvant treatment to improve the quality of life in patients with COVID-19 and to limit post-traumatic stress symptoms. However, one should be aware of side effects of CBD (which are rarely serious), drug interactions (also extending to drugs acting against COVID-19) and the proper route of its administration (vaping may be dangerous). Clearly, further clinical studies are necessary to prove the suitability of CBD for the treatment of COVID-19.

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“…As a traditional source for modern pharmaceutical discovery and potential drug leads, natural products have played an integral role in treating patients due to their unique structural, chemical, and biological diversity [ 1 , 2 , 3 ]. The current race to identify efficacious drugs, natural products with promising therapeutic effects has attracted significant attention, especially for the prevention and treatment of lung diseases, such as pulmonary fibrosis [ 4 ], asthma [ 5 ], acute lung injury [ 6 ], chronic obstructive pulmonary disease [ 7 ], defective pulmonary innate immunity [ 8 ], coronavirus disease 2019 (COVID-19) [ 9 ], and lung cancer [ 10 ]. Among the myriad of known lung maladies, COVID-19 and lung cancer are currently the most important public health concerns and burdens worldwide [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

Yang

Wang

2021

Biomedicines

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As a public health emergency of international concern, the highly contagious coronavirus disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of billions of individuals. Lung cancer, a malignant tumor with the highest mortality rate, has brought significant challenges to both human health and economic development. Natural products may play a pivotal role in treating lung diseases. We reviewed published studies relating to natural products, used alone or in combination with US Food and Drug Administration-approved drugs, active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and lung cancer from 1 January 2020 to 31 May 2021. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib). Natural products have demonstrated potential value and with the assistance of nanotechnology, combination drug therapies, and the codrug strategy, this “natural remedy” could serve as a starting point for further drug development in treating these lung diseases.

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Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Abstract: Graphical abstract

Cited by 226 publications

References 434 publications

COVID-19, cytokines, inflammation, and spices: How are they related?

COVID-19, cytokines, inflammation, and spices: How are they related?

Opportunities, Challenges and Pitfalls of Using Cannabidiol as an Adjuvant Drug in COVID-19

Natural Products, Alone or in Combination with FDA-Approved Drugs, to Treat COVID-19 and Lung Cancer

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