Elevated advanced oxidation protein products levels in patients with liver cirrhosis.

Abstract

Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.

Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis.

“…The present study provides several lines of evidence to suggest that advanced oxidation protein products that we previously biochemically characterized in plasma from cirrhotic patients (Zuwała-Jagiełło et al, 2009) act as mediators of the chronic inflammatory state associated with alcohol-related compensated cirrhosis.…”

Monitoring oxidative stress in acute‐on‐chronic liver failure by advanced oxidation protein products

“…The MELD score is a reliable measure of mortality risk in patients with end‐stage liver disease. Likewise, Zuwała‐Jagiełło discovered that patients with decompensated liver cirrhosis with higher MELD scores have higher concentrations of AOPP than compensated patients 26 . Furthermore, the TBIL mirrored the severity of acute hepatocellular injury in ACLF patients.…”

Histopatological alterations and oxidative stress in liver and kidney of Leuciscus cephalus following exposure to heavy metals in the Tur River, North Western Romania

“…These results in deamination of lysyl residues and/or oxidation of tyrosyl and hystidyl residues (Witko-Sarsat et al, 1999) and can be correlated with levels of dityrosine (Zuwala-Jagiello et al, 2009) and resistance to proteolysis. Fish tissues collected downstream showed moderately elevated levels of AOPP in liver and kidneys of L. cephalus (increase by 36% and 31%) compared to those from upstream river (Fig.…”