Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis.

Zuwała−Jagiełło, Jolanta; Pazgan−Simon, Monika; Simon, Krzysztof; Warwas, Maria

doi:10.18388/abp.2011_2286

Cited by 29 publications

(24 citation statements)

References 49 publications

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“…In contrast, other studies have shown elevated CRP levels in CHC infection . In a study of patients with angiographically documented CAD, CRP, and fibrinogen levels were significantly elevated in HCV‐infected patients compared to controls and HCV seropositivity was associated with increased severity of CAD .…”

Section: Resultsmentioning

confidence: 69%

“…21 TNF-dependent processes are up regulated and activated in CHC, and TNF-α mRNA is ubiquitously expressed in hepatocytes, Kupffer cells, and infiltrating mononuclear cells at higher levels in CHC patients than in healthy controls. 22,23 31 Falasca et al 32 Helaly et al 33 Khan et al 34 Migita et al 36 Zekri et al 37 Malaguarnera et al 38 Costantini et al 39 Capone et al 40 Oyanagi et al 41 Lapinski et al 42 Lecube et al 43 Sandler et al 44a Grungreiff et al 46a Cotler et al 48a Hung et al 49 Antonelli et al 50 Shive et al 52 Cua et al 53 Grungreiff et al 54 Lee et al 84 Mishra et al 87 Sousa et al 91 Tsui et al 35 Zuwała-Jagiełło et al 57 Mourtzikou et al 58 Han et al 85 Müller et al 92…”

Section: Biomarkers Of Inflammationmentioning

confidence: 99%

“…Migita et al 36 Zekri et al 37 TNF-α Larrea et al 22 a Oliveira et al 31 Falasca et al 32 Helaly et al 33 Khan et al 34 Tsui et al 35 Zekri et al 37 Lecube et al 43 Hung et al 49 Cua et al 53 Zuwała-Jagiełło et al 57 Mourtzikou et al 58 Akcam et al 59 Talaat et al 60 Abdel-Latif et al 61 Kallinowski et al 62a Al-Jiffri 63 Kaplanski et al 64 Jia et al 65a El-Bassiouni et al 66 Antonelli et al 67 Sayed-Ahmed et al 69 Toyoda et al 70a Kishihara et al 71a Raghuraman et al 72 Valenti L et al 73 Nelson et al 75 Glowacki et al 76 Riordan et al 77 32 Khan et al 34 Capone et al 40 Hung et al 49 Mourtzikou et al 58 Akcam et al 59…”

Section: Il-6rmentioning

confidence: 99%

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Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Babiker

Hassan

Muhammed

et al. 2019

Clinical Cardiology

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Hepatitis C virus (HCV) infects 180 million people worldwide and over 4 million people in the United States. HCV infection is a major cause of chronic liver disease and is recognized as a risk factor for clinical cardiovascular disease (CVD). Many studies have shown increased prevalence of cardiac and inflammatory biomarkers in patients with chronic HCV infection (CHC), and though these markers may be used to risk stratify people for cardiac disease in the general population their role in the HCV population is unknown. Patients with CHC have elevated cardiac and inflammatory biomarkers compared to noninfected controls which may play a role in CVD risk stratification. We undertook a systematic review of inflammatory and cardiac biomarkers in people with HCV infection with a focus on the effect of CHC on serum levels of these markers and their utility as predictors of CVD in this population. Medline, EMBASE, and Cochrane databases were searched for relevant articles until June 2019. A total of 2430 results were reviewed with 115 studies included. Our review revealed that HCV infection significantly alters serum levels of markers of inflammation, endothelial function, and cardiac dysfunction prior to HCV treatment, and some of which may change in response to HCV therapy. Current risk stratification tools for development of CVD in the general population may not account for the increased inflammatory markers that appear to be elevated among HCV‐infected patients contributing to increased CVD risk.

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Section: Resultsmentioning

confidence: 69%

Section: Biomarkers Of Inflammationmentioning

confidence: 99%

Section: Il-6rmentioning

confidence: 99%

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Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Babiker

Hassan

Muhammed

et al. 2019

Clinical Cardiology

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“…Lipid peroxidation and advanced oxidation protein products as well as 8-hydroxydeoxyguanosine (8-OHdG) are ROS-modified biological molecules, and were found at significantly higher levels in PBMCs in HCV patients compared to healthy controls ([19,28,29,32,33,34,39,40] and others). Significant increase of 8-OHdG was detected in situ in liver samples from CHC patients [41].…”

Section: Oxidative Stress In Patients With Chronic Hepatitis Cmentioning

confidence: 99%

HCV and Oxidative Stress in the Liver

Ivanov

Bartosch

Smirnova

et al. 2013

Viruses

182

151

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Hepatitis C virus (HCV) is the etiological agent accounting for chronic liver disease in approximately 2–3% of the population worldwide. HCV infection often leads to liver fibrosis and cirrhosis, various metabolic alterations including steatosis, insulin and interferon resistance or iron overload, and development of hepatocellular carcinoma or non-Hodgkin lymphoma. Multiple molecular mechanisms that trigger the emergence and development of each of these pathogenic processes have been identified so far. One of these involves marked induction of a reactive oxygen species (ROS) in infected cells leading to oxidative stress. To date, markers of oxidative stress were observed both in chronic hepatitis C patients and in various in vitro systems, including replicons or stable cell lines expressing viral proteins. The search for ROS sources in HCV-infected cells revealed several mechanisms of ROS production and thus a number of cellular proteins have become targets for future studies. Furthermore, during last several years it has been shown that HCV modifies antioxidant defense mechanisms. The aim of this review is to summarize the present state of art in the field and to try to predict directions for future studies.

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“…Although structure of several AGEs has been reported, it has been demonstrated that Nε‐(carboxymethyl) lysine (CML) is the major antigenic AGE structure . Serum concentration of CML is also increased in diabetic patients with complications like nephropathy , retinopathy and atherosclerosis . CML is also recognized by RAGE and the interaction of CML–RAGE activates signaling pathways like NF‐B .…”

Section: Immunochemical Techniques Used For Detection and Measurementmentioning

confidence: 99%

Recent advances in detection of AGEs: Immunochemical, bioanalytical and biochemical approaches

et al. 2015

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Advanced glycation end products (AGEs) are a cohort of heterogeneous compounds that are formed after the nonenzymatic glycation of proteins, lipids and nucleic acids. Accumulation of AGEs in the body is implicated in various pathophysiological conditions like diabetes, cardiovascular diseases and atherosclerosis. Numerous studies have reported the connecting link between AGEs and the various complications associated with diseases. Hence, detection and measurement of AGEs becomes centrally important to understand and manage the menace created by AGEs inside the body. In recent years, an increasing number of immunotechniques as well as bioanalytical techniques have been developed to efficiently measure the levels of AGEs, but most of them are still far away from being clinically consistent, as relative disparity and ambiguity masks their standardization. This article is designed to critically review the recent advances and the emerging techniques for detection of AGEs. It is an attempt to summarize the major techniques that exist currently for the detection of AGEs both qualitatively and quantitatively. This review primarily focuses on the detection and quantification of AGEs which are formed in vivo. Immunochemical approach though costly but most effective and accurate method to measure the level of AGEs. Literature review suggests that detection of autoantibody targeting AGEs is a promising way that can be utilized for detection of AGEs. Future research efforts should be dedicated to develop this method in order to push forward the clinical applications of detection of AGEs. V C 2015 IUBMB Life, 67(12):897-913, 2015

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Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis.

Cited by 29 publications

References 49 publications

Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review

HCV and Oxidative Stress in the Liver

Recent advances in detection of AGEs: Immunochemical, bioanalytical and biochemical approaches

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