Electrosprayed inulin microparticles for microbiota triggered targeting of colon

Jain, Arvind; Sood, Vishesh; Bora, Meghali; Vasita, Rajesh; Katti, Dhirendra S.

doi:10.1016/j.carbpol.2014.05.087

Cited by 70 publications

(31 citation statements)

References 21 publications

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“…At higher WG concentrations, molecules tend to agglomerate among themselves, compared to the lowest concentration, where the molecules are farther apart; similar results were reported by Jain et al [46] There is less viscosity, hence better stability. As we predicted, this parameter possessed great variation throughout the speed ramp.…”

Section: Rheology Of Wheat Gluten Solutionssupporting

confidence: 81%

Porous wheat gluten microparticles obtained by electrospray: Preparation and characterization

et al. 2017

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Currently, microporous polymer materials are being studied extensively due to their attractive properties which allow for a wide potential of applications, such as prolonged-release systems (PRS). The objective of the present work was to prepare and characterize porous microparticles of wheat gluten (WG) using the electrospray technique. The effect of the physicochemical parameters of the solution and electrospray technique parameters on the morphology and size of the materials obtained was studied. For all of the concentrations of WG, porous microparticles with sphere geometry were obtained. At higher concentrations of WG (8% w/v), higher values of viscosity (0.32405 ± 0.002 Pa·s), density (0.997 ± 0.0005 g/cm 3 ), and particle size (1.42 ± 0.71 μm) were obtained, while at lower concentration, high stability rheological is presented, which exhibited Newtonian fluid behavior. Characterization by scanning electron microscopy (SEM), Fourier transform-infrared spectroscopy (FT-IR), and X-ray diffraction indicated that the material obtained has a potential application in the PRS industry. K E Y W O R D SFourier transform-infrared spectroscopy, porous microparticles, rheology, wheat gluten, X-ray

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Section: Rheology Of Wheat Gluten Solutionssupporting

confidence: 81%

Porous wheat gluten microparticles obtained by electrospray: Preparation and characterization

et al. 2017

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“…With these results, it may be concluded that 1% w/v of GA is more stable for the formation of nanoparticles with a similar morphology and monodisperse particles during the electrospray process and as corroborated in Figure . When an electrosprayed solution possesses less viscosity and less change in viscosity with respect to time, thus, better stability, it remains constant during the electrospray technique and tends to form more uniform and monodispersed particles (Jain, Sood, Bora, Vasita, & Katti, ; Tapia‐Hernández et al., ).…”

Section: Resultsmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

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“…68 release of paclitaxel was triggered by ultrasound stimulation and the release profile could be controlled by the length of repeatable ultrasonication time. Jain et al 65 successfully prepared indomethacin-loaded spherical microparticles for colon-targeted drug delivery. By using inulin acetate as carrier, in vitro release studies in simulated gastrointestinal conditions showed that indomethacin was only released when the particles were incubated in inulinase-containing simulated colonic fluid (pH 6.8).…”

Section: Preparation Of Targeted Drug Delivery Systemsmentioning

confidence: 99%

Pharmaceutical Applications of Electrospraying

Nguyen

Clasen

Mooter

2016

Journal of Pharmaceutical Sciences

154

128

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The electrohydrodynamic atomization technique, or simply called electrospraying, has been extensively studied for biomedical as well as for pharmaceutical applications over the past years. The simplicity, flexibility, and efficiency of producing particles at the microscale or nanoscale, with tailored size, shape, morphology, and microstructure, make electrospraying to become one of the most promising and well-practiced approaches to be applied in many biomedical and pharmaceutical fields, from improving the bioavailability of poorly aqueous soluble drugs, preparing targeted drug delivery systems, and controllable drug release systems to delivering sensitive therapeutic agents such as protein-based drugs or even living cells. Nevertheless, some issues still remain with respect to low throughput as well as the complex interplay between a great number of processing and formulation factors. A comprehensive understanding of these fundamental aspects is essential for the successful application of electrospraying for the production of particulate formulations with desired properties.

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Electrosprayed inulin microparticles for microbiota triggered targeting of colon

Cited by 70 publications

References 21 publications

Porous wheat gluten microparticles obtained by electrospray: Preparation and characterization

Porous wheat gluten microparticles obtained by electrospray: Preparation and characterization

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Pharmaceutical Applications of Electrospraying

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