Pharmaceutical Applications of Electrospraying

Nguyen, Duong Nhat; Clasen, Christian; Mooter, Guy Van den

doi:10.1016/j.xphs.2016.04.024

Cited by 154 publications

(138 citation statements)

References 166 publications

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“…A high voltage potential on the needle forces the polymer solution out of the syringe and results in the formation of a jet that breaks into monodisperse droplets, which form the microparticles. Electrospraying is associated with many advantages including the ability to fabricate particles with narrow size distribution, its experimental setup requires low investment and it allows for scalable fabrication . A main reason for using electrospraying instead of the common emulsion solvent extraction/evaporation technique is that electrospraying is associated with high entrapment efficiency .…”

Section: Introductionmentioning

confidence: 99%

“…Electrospraying is associated with many advantages including the ability to fabricate particles with narrow size distribution, its experimental setup requires low investment and it allows for scalable fabrication. 31,32 A main reason for using electrospraying instead of the common emulsion solvent extraction/evaporation technique is that electrospraying is associated with high entrapment efficiency. 32 The effects of solvent used for fabrication (i.e., different volume ratio of dichloromethane [DCM] and acetonitrile) of TMZloaded PLGA microparticles fabricated by electrospraying on drug loading, loading efficiency, drug release kinetics, surface morphology, and particle size were determined.…”

Section: Introductionmentioning

confidence: 99%

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Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide‐loaded PLGA microparticles for the treatment of glioblastoma

et al. 2019

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Glioblastoma multiforme (GBM) is the most common and invasive form of malignant brain tumors and despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with GBM still remains poor. Temozolomide (TMZ) is the chemotherapy drug that is most commonly given orally after surgical resection of these tumors. In this study, the effects of solvents (i.e., dichloromethane and acetonitrile) used for the fabrication of electrosprayed TMZ‐loaded poly(lactic‐co‐glycolic acid) (PLGA) on drug loading, loading efficiency, drug release kinetics, surface morphology, and particle size were investigated. The results from this study demonstrated that by using a larger volume of a solvent with higher polarity (i.e., acetonitrile) which allows for a higher amount of hydrophilic TMZ to dissolve into the polymer solution, higher drug loading could be achieved. However, the particles fabricated with high amount of acetonitrile, which has a lower vapor pressure, had large pores and a smaller diameter which led to an initial burst release and high cumulative release at the end of the study. An optimal combination of the two solvents is needed to result in particles with a good amount of loading and minimal initial burst release. The electrosprayed microparticles were able to illicit a cytotoxic response in U‐87 MG glioblastoma cells at a lower concentration of drug compared to the free drug. This work indicated that electrospraying is a promising method for the fabrication of TMZ‐loaded PLGA microparticles for the treatment of GBM and solvent composition can be altered to control drug loading and release kinetics. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2317–2324, 2019.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide‐loaded PLGA microparticles for the treatment of glioblastoma

et al. 2019

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“…Finally, the working distance, or the distance between the tip and the collector (TTC), is also an important parameter. At a constant voltage, a short distance is advantageous for generating a high electrical field strength, and a long TTC distance would require a higher applied voltage to compensate for the reduced electrical field strength to obtain particles …”

Section: Discussionmentioning

confidence: 99%

“…Another study indicated that electrospray can produce microspheres with a controlled size and morphology at room temperature . Controlling electrospinning parameters in electrospray is a flexible and versatile method to prepare microspheres with customized microstructures and tailored properties, including size, morphology, and shape, for many kinds of biomedical applications . However, some studies have recently shown that there are several limitations associated with microsphere electrospinning, including a difficulty in achieving zero‐order drug release, a lack of long‐term release of drugs, and an initial burst release caused by rapid release of drug located on or near the external surface…”

Section: Introductionmentioning

confidence: 99%

Effect of microsphere size on the drug release and experimental characterization of an electrospun naringin‐loaded microsphere/sucrose acetate isobutyrate (SAIB) depot

Zhang

Song

Almassri

et al. 2020

Polymers for Advanced Techs

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The aims of this study were to prepare different sizes of electrospun naringin-loaded microspheres (Ng-ms) and investigate the effects of the particle size of these microspheres on drug release from naringin-loaded microsphere/sucrose acetate isobutyrate (Ng-m-SAIB) hybrid depots to develop an improved drug delivery system for tissue engineering. Different sizes of microspheres were produced using electrospray methods by controlling electrospinning parameters. The Ng-m-SAIB depots were prepared by dispersing Ng-ms in SAIB depots. The morphology and size distributions of the electrospun Ng-ms were characterized by polarizing microscopy and scanning electron microscopy (SEM). To better understand the release behavior of Ng-m-SAIB, the porosity of SAIB depots was measured. Consequently, both small (2.51 ± 0.191 μm) and large (5.03 ± 0.172 μm) microspheres exhibited smooth surfaces and good monodispersity. The initial and long-term drug release rates of the large microspheres were lower than those of small microspheres. On the first day after 2.5-μm and 5-μm Ng-m-SAIB depots were produced, the burst release reduced dramatically from 68.79% to 3.30% and from 63.20% to 0.00%, respectively. After 92 days of release, the drug release rate of 5-μm Ng-m-SAIB was still lower than that of 2.5-μm Ng-m-SAIB, with values of 58.54% and 63.93%, respectively. These results demonstrate that drug release from Ng-m-SAIB depots can be tailored solely by varying the size of the microspheres and that good drug release behavior occurred. K E Y W O R D S drug release system, electrospray, microspheres, naringin, sucrose acetate isobutyrate

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“…Despite all the advantages associated polymers, such as poly-lactide-co-glycolide (PLGA), polycaprolactone (PCL) etc. has found its biggest applications in biomedical engineering [4][5][6][7] and drug delivery [8][9][10][11][12][13][14]. Despite all the advantages associated with electrospraying, nevertheless, the optimization of the spraying procedure has been based on a time-consuming trial-and-error process.…”

Section: Introductionmentioning

confidence: 99%

An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles

et al. 2019

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Electrospraying has been recognized as an important technique for the production of microparticles for pharmaceutical applications. Nevertheless, the produce of poly (d,l)-lactide-co-glycolide (PLGA) microspheres with a desired size distribution remains a challenge. We conducted an empirical study, based on a fractional orthogonal design, to optimize the size distribution of electrosprayed particles. The influence of different processing factors, including PLGA concentration in the solution, volumetric flow rate of the solution, travel distance between the needle tip and the collection, voltage applied to the polymer solution, size of the needle, and type of solvent on the electrospraying of polymeric microparticles was investigated. After electrospraying, the size distribution of the PLGA particles was characterized and analyzed. Among the selected factors, the type of solvent used was the principal factor affecting the particle size of electrosprayed microspheres. Hexafluoro-2-propanol (HFIP) electrosprayed microparticles with the smallest diameter. However, hollowed particles could be seen among these microspheres. Dichloromethane (DCM) was found to electrospray microspheres with a fairly spherical geometry, while trichloromethane (TCM) electrosprayed particles with relatively rougher surfaces. Finally, the particle size of sprayed microspheres decreases somewhat with the polymer concentration and travel distance.with electrospraying, nevertheless, the optimization of the spraying procedure has been based on a time-consuming trial-and-error process.In past three decades, PLGA has been one of the most attractive polymeric materials used to manufacture devices for drug delivery and tissue engineering applications [15]. PLGA is biocompatible and biodegradable, possesses a wide range of erosion times, has tunable mechanical strengths, and most importantly, is a FDA approved polymer. Crystalline PGA, when co-polymerized with PLA, reduces the degree of crystallinity of PLGA, and as a result, increases the rate of hydration and hydrolysis. As a rule, a higher content of PGA leads to quicker rates of degradation, with an exception of 50:50 ratio of PLA/PGA, which exhibits the fastest degradation. A ratio of 50:50 PLGAs have been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research [16].An empirical study, based on a fractional orthogonal array design, was completed to investigate the effect of different processing factors on the size distribution of electrosprayed particles. 50:50 PLGA materials were selected. Experiments were carried out on an electrospraying setup consisting of a syringe and needle, a ground electrode, and a high voltage supply. After electrospraying, the particle size and morphology were characterized by a scanning electron microscope. A fractional orthogonal was designed based on a design matrix proposed by Dr. Genichi Taguchi [17]. It allows one to examine a selected subset of combin...

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Pharmaceutical Applications of Electrospraying

Cited by 154 publications

References 166 publications

Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide‐loaded PLGA microparticles for the treatment of glioblastoma

Effects of solvent used for fabrication on drug loading and release kinetics of electrosprayed temozolomide‐loaded PLGA microparticles for the treatment of glioblastoma

Effect of microsphere size on the drug release and experimental characterization of an electrospun naringin‐loaded microsphere/sucrose acetate isobutyrate (SAIB) depot

An Orthogonal Model to Study the Effect of Electrospraying Parameters on the Morphology of poly (d,l)-lactide-co-glycolide (PLGA) Particles

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