Electrochemistry of dopamine at the polarised liquid|liquid interface facilitated by an homo-oxo-calix[3]arene ionophore

Herzog, Grégoire; McMahon, Brian; Lefoix, Myriam; Mullins, Nicholas D.; Collins, Courtney J.; Moynihan, Humphrey A.; Arrigan, Damien W. M.

doi:10.1016/j.jelechem.2008.05.006

Cited by 21 publications

(19 citation statements)

References 32 publications

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“…In recent years there have been many reports on the behaviour and detection of biomolecules at the ITIES. The detection of a range of biomolecules including amino acids [19], heparin [20,21], protamine [22,23], haemoglobin [24,25], lysozyme [26,27], insulin [28], dopamine [29][30][31], noradrenaline [31] and DNA [32] have been reported at the ITIES.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical behaviour of myoglobin at an array of microscopic liquid–liquid interfaces

O'Sullivan

Arrigan

2012

Electrochimica Acta

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Electrochemistry at liquid-liquid interfaces, or at interfaces between two immiscible electrolyte solutions (ITIES), provides a basis for the non-redox detection of biological molecules, based on iontransfer or adsorption processes. The electroactivity of myoglobin at an array of micron-sized liquidorganogel interfaces was investigated. The µITIES array was patterned with a silicon membrane consisting of an array of eight pores with radii of ~12.8 µm and a pore to pore separation of ~400 µm.Using cyclic voltammetry at the ITIES, the protein was shown to adsorb at the interface and facilitate the transfer of the organic phase electrolyte anions to the aqueous side of the interface. The electrochemical current response was linear with concentration in the range of 1 -6 µM, with corresponding surface coverage of 10 -50 pmol cm -2 . The reverse peak currents was found to be proportional to the voltammetric scan rate, indicating a desorption process. The detection of the protein was only possibly when the pH of the aqueous phase solution was below the pI of the protein. The steady-state simple ion transfer behaviour of tetraethylammonium cation was decreased on the forward sweep, providing a qualitative indication of the presence of adsorbed protein at the interface.Increasing the ionic strength of the aqueous phase resulted in enhanced peak currents, possibly due to aggregation of protein precipitates in the aqueous solution. UV/Vis absorbance spectroscopy was used 1 ISE Member.2 | P a g e to investigate the effects of various aqueous electrolyte solutions on the structure of the protein, and it was shown that at low pH the protein is at least partially denatured. These results provide the basis for label-free detection of myoglobin at the ITIES.

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Section: Introductionmentioning

confidence: 99%

Electrochemical behaviour of myoglobin at an array of microscopic liquid–liquid interfaces

O'Sullivan

Arrigan

2012

Electrochimica Acta

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“…Ion transfer voltammetry of aromatic amines, including amino acids, dipeptides, neurotransmitters, and anesthetics, at the organic solvent (O)|water (W) interface has been studied by many authors [7][8][9][10][11][12][13][14][15][16][17][18]. Much attention has been paid to the hydrophobicity of protonated cations of the aromatic amines, as determined by the reversible half-wave potentials of the voltammograms, and to the relationship to their biological or pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Ion transfer voltammetry of tryptamine, serotonin, and tryptophan at the nitrobenzene/water interface

Tatsumi

Ueda

2011

Journal of Electroanalytical Chemistry

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The transfer of the cationic forms of tryptamine and serotonin across the nitrobenzene (NB)|water (W) interface was studied by cyclic voltammetry. Well-defined voltammetric waves were observed within the potential window. The standard potentials of the transfer were determined from the midpoint potentials of the voltammograms.The transfer of the cationic form of tryptophan across the NB|W interface was also observed using an acidic aqueous solution.

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“…Similarly, Arrigan et al [42][43][44] studied the DAH + transfer across the water/DCE interface facilitated by the DB18C6 ionophore from the analytical point of view. The sensitivity [44,45], selectivity in the presence of ascorbate [42,43] and effect of the nature of ligands [45] on the determination of DAH + was extensively studied by Arrigans research group. They achieved a limit of detection (LOD) of 3.8 mM by SWV for the homooxocalix [3]areneassisted transfer of DAH + across the interface [45].…”

Section: Introductionmentioning

confidence: 99%

“…The sensitivity [44,45], selectivity in the presence of ascorbate [42,43] and effect of the nature of ligands [45] on the determination of DAH + was extensively studied by Arrigans research group. They achieved a limit of detection (LOD) of 3.8 mM by SWV for the homooxocalix [3]areneassisted transfer of DAH + across the interface [45]. The LOD was then improved to 0.5 mM by the use of microporous array membrane at the same interface and using DB18C6 as ionophore [44].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensing of Catecholamines at the Water/ 1,6‐Dichlorohexane Interface

2013

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In this work, the analytical use of facilitated ion transfer of catecholamines by dibenzo-18-crown-6 was investigated at the water/1,6-dichlorohexane interface using electrochemical methods (cyclic and square wave voltammetry). The experimental conditions for the analytical determination of noradrenaline and dopamine were established and detection limits of 1.7 and 0.35 mM were obtained, respectively. The effect of excess ascorbic acid on the transfer and detection of the two catecholamines was investigated. The selectivity coefficients obtained for dopamine and noradrenaline in the presence of ascorbic acid were 3.5 10 À4 and 2.5 10 À3 , respectively.

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Electrochemistry of dopamine at the polarised liquid|liquid interface facilitated by an homo-oxo-calix[3]arene ionophore

Cited by 21 publications

References 32 publications

Electrochemical behaviour of myoglobin at an array of microscopic liquid–liquid interfaces

Electrochemical behaviour of myoglobin at an array of microscopic liquid–liquid interfaces

Ion transfer voltammetry of tryptamine, serotonin, and tryptophan at the nitrobenzene/water interface

Electrochemical Sensing of Catecholamines at the Water/ 1,6‐Dichlorohexane Interface

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