Elastic Polymeric Network Structure for Slow Release Drug Delivery Systems

Helaly, F. M.; Essawy, Hisham; Shabana, Mohamed A.

doi:10.1080/03602559.2010.543234

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…As a borneol polymeric ester, PLAB could be a potential solid borneol spice, polymeric drug, and biodegradable functional drug carrier and its molecular weight could be controlled by synthetic conditions. Now, the functional modification of PLA has been an important direction in PLA researches [35][36][37][38][39], this work will further promote its development in the future. …”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of a novel functional biodegradable material, poly(lactic acid-co-borneol)

Mao

Luo

Wang

et al. 2012

Designed Monomers and Polymers

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Directly starting from D,L-lactic acid (LA) and L-borneol, novel biodegradable material poly(lactic acid-co-borneol) (PLAB) was synthesized via melt polycondensation. When the molar feed ratio LA/borneol is 64/1, the influences of different conditions including catalyst kinds and its dosage, copolymerization time, and temperature on the synthesis of the polymer are discussed. When the SnO was used as catalyst and the dosage was 0.3 wt% of the prepolymer, the 5 h direct melt polycondensation at 170°C and absolute pressure of 70 Pa after prepolymerization gave the copolymer with the maximum intrinsic viscosity [η], 1.51 dL g À1 . The structure of copolymer was confirmed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance ( 1 H-NMR). According to the appropriate synthetic conditions, the copolymers with different molar feed ratios were synthesized and systematically characterized by [η], gel permeation chromatography (GPC), differential scanning calorimetry, thermogravimetric, and X-ray diffraction (XRD). The GPC results show that the maximum weight average molecular weight (M w ) of PLAB is 11,900, when the molar feed ratio LA/borneol is 64/1. With the increase of the molar feed ratio of borneol, [η], M w and its polydispersity index (M w /M n ) increase gradually. Due to the introduction of borneol into the copolymer, the glass-transition temperature (T g ) decreases gradually with the increasing feed ratio of borneol. The direct melt copolycondensation is a cheap and practical method for the synthesis of borneol modified polylactic acid, a potential solid borneol flavor, polymeric drug, and functional drug carrier.

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Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of a novel functional biodegradable material, poly(lactic acid-co-borneol)

Mao

Luo

Wang

et al. 2012

Designed Monomers and Polymers

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“…Then, newly developed polymers are rapidly utilized for medical applications based on their monomer's functional group properties. Having aromatic rings, phenyl methacrylate is considered a reactive monomer, and it is suitable to tune their biological behavior by substituting various functional groups in different ring positions [5,6]. Aliphatic substituted methacrylate copolymers are showing high efficiency against human pathogenic organisms [7].…”

Section: Introductionmentioning

confidence: 99%

Design of Novel Poly(Propranolol) Acrylate and Methacrylate Polymers through Radical Polymerization for Antibacterial Activity and Metal Ion Absorption

Kumar,

Kamaraj,

Vivekanand

et al. 2024

International Journal of Polymer Science

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The monomer 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanoacrylate (IANOPA) and monomer 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanomethacrylate (IANOPMA) were synthesized by treating 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol with acryloylchloride/methacryloyl chloride. The above esterification reactions were carried out in the presence of triethylamine. By employing the free radical polymerization method, the synthesized monomers were converted into polymers by using an initiator 2, 2′-azobisisobutyronitrile in the presence of nitrogen environment at 70±2°C. The monomers and polymers were characterized by various techniques such as FT-IR, UV, 1H NMR, and 13C NMR spectroscopic analyses. Further, differential scanning calorimetry (DSC) was used to estimate the glass transition temperature (Tg). Gel permeation chromatography (GPC) was used to estimate the molecular weight of the polymers. In addition, monomer and polymer surfaces’ morphology was analyzed using SEM analysis. As a primary application, the effectiveness of synthesized monomers and polymers was explored as antibacterial agents against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacteria (Pseudomonas aeruginosa) which were measured from their inhibitory zone diameters. Further, the synthesized polymers, poly-IANOPA and poly-IANOPMA, were utilized for the uptake ability study of heavy metal ions such as Zn2+, Cu2+, Ni2+, and Pb2+ present in water sources by equilibrium method.

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“…Phenyl methacrylates are reactive monomers due to the presence of aromatic ring. They have higher thermal stability which gains much interest due to its potential industrial applications [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Study of Antibacterial Activity of Methacrylic Copolymer

Mageswari

Subramanian

2012

Polymer-Plastics Technology and Engineering

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4-Benzyloxyphenylmethacrylic copolymers with Glycidyl methacrylate were synthesized from the monomer, 4-Benzyloxyphenylmethacrylate (4-BOPMA) by free radical solution polymerization. The synthesized monomer and co-polymer were characterized by UV, FT-IR, H 1 -NMR and C 13 -NMR spectroscopic techniques. The thermal stability of the polymers was determined by TGA in inert atmosphere. The glass transition temperatures of the polymers were determined by DSC analysis. The antibacterial activities of the polymers were also studied by UV spectroscopy at various concentration. The results of the TGA analysis showed that the polymers had good stability upto 250 C. Compared to homopolymer, the copolymer shows a broad spectrum of antibacterial properties.

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Elastic Polymeric Network Structure for Slow Release Drug Delivery Systems

Cited by 7 publications

References 20 publications

Synthesis and characterization of a novel functional biodegradable material, poly(lactic acid-co-borneol)

Synthesis and characterization of a novel functional biodegradable material, poly(lactic acid-co-borneol)

Design of Novel Poly(Propranolol) Acrylate and Methacrylate Polymers through Radical Polymerization for Antibacterial Activity and Metal Ion Absorption

Synthesis, Characterization and Study of Antibacterial Activity of Methacrylic Copolymer

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