Efficacy of Tulathramycin in the Treatment of Respiratory Pasteurollosis in Rabbits

Abstract

| Pasteurella multocida is the most critical respiratory bacterial infection of rabbits, around the globe. Beside passive immunization, anti-bacterial treatment is the primary choice of disease control. Since tulathromycin may be retained in the lung for many days after single administration, it can be applied for treatment of respiratory diseases. Hence, the purpose of current study was to evaluate the efficacy of tulathromycin in treating experimentally infected rabbits with P. multocida. In the sensitivity test, tulathromycin showed a potent inhibitory effect on P. multocida compared to several well-established antimicrobial agents. In vivo, treatment with tulathromycin improved clinical signs, mortality rate, lesion scores and growth performance parameters in infected rabbits. Furthermore, treatment with tulathromycin ameliorated the hematological picture, lowered the level of biochemical parameters which were significantly increased due to infection as liver enzymes, blood urea, creatinine and creatine kinase (CK-MB) and elevated the levels of total protein and albumin. Biochemical findings were supported by histopathological picture. It can be concluded that tulathromycin is an ideal and safe antibiotic for treating infection with Pasteurella multocida in rabbits.

Efficacy of grape seed hydro‐alcoholic extract in the treatment of experimentally Pasteurella multocida infected rabbits

“…Lymphocytopenia is commonly accompanied by a rise in neutrophil count in various infectious causes (Hawkins et al., 2006; Seebach et al., 1997; Wyllie et al., 2004). Our haematological results were supported by those of (Alam et al., 2018; Edrees et al., 2017). The treatment of P. multocida ‐infected rabbits with GSE improves the haematological status compared to infected non‐treated rabbits.…”

“…Lymphocytopenia is commonly accompanied by a rise in neutrophil count in various infectious causes (Hawkins et al, 2006;Seebach et al, 1997;Wyllie et al, 2004). Our haematological results were supported by those of (Alam et al, 2018;Edrees et al, 2017).…”

“…This is due to off food and poor appetite. These results were supported by the studies (Alam et al., 2018; Edrees et al., 2017). Infected groups treated with GSE for five successive days showed milder clinical symptoms, reduction in mortality rate, and significant improvement of BW and BWG compared to the infected non‐treated group.…”

“…This is due to off food and poor appetite. These results were supported by the studies (Alam et al, 2018;Edrees et al, 2017).…”