R abbits are viewed as one of the essential domesticated animals that give high quality protein sustenance. One of the most important health problems in rabbit is pasteurellosis, which is considered as a common bacterial disease caused by Pasteurella multocida (P. multocida) and has been reported as a constant serious and highly contagious disease of domestic rabbits (Nassar et al., 2013). Rabbit pasteurellosis causes symptoms that range from fatal septicemia, severe pleuritis, and pneumonia to less severe sequelae such as multiple abscesses, chronic rhinitis, and otitis media. It mostly affects rabbits at 4-8 weeks of age causing manifestations going from lethal septicemia, serious pleuritis, and pneumonia to less extreme sequelae, for example, various abscesses, perpetual rhinitis, and otitis media. The result of any type of the ailment is extreme financial misfortunes. Rabbits older than 8months to 1 year of age showed lower incidence (Mohamed et al., 2019). Pasteurellosis exhibited 3 forms in rabbits. The first one is snuffles or nasal catarrhal inflammation which is characterized by acute, subacute, and chronic inflammation of the air passages and lungs. This form of the disease often ends with death and the cured animals became carriers. The second form is characterized by abscess formation at any part of the body and the case is terminated with septicemia. The last form is characterized by genital infection, which manifests as acute and subacute inflammation of uterus

Rabbit production is very important to improve the consumption of animal proteins in developing nations (Adeyinka, 2007). The occurrence of diseases is inevitable in any animal production unit and leads to prospective economic losses (Quesada et al., 2013). Pasteurellosis induced by Pasteurella multocida (P. multocida), a virulent and readily transmitted coccobacillus, is one of the rabbit's most serious bacterial diseases and leads to great financial damages in big production systems worldwide (Takashima et al., 2001). This disease is characterized by multiple clinical symptoms, like respiratory distress, genital disorders, otitis, abscesses and septicaemia, but P. multocida infection may also asymptomatic (Jaglic et al., 2008). Rabbits could become infected with P. multocida instantly after birth, and the incidence of colonization rises with age to approximately 5 months. Most adult rabbits are thought to have been infected with P. multocida (Palócz et al., 2014).

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