Histopathological Effects of using Grape Seed Extract Alone or in Combination with Ofloxacin against Pasteurella Multocida in Rabbits

Abstract

R abbits are viewed as one of the essential domesticated animals that give high quality protein sustenance. One of the most important health problems in rabbit is pasteurellosis, which is considered as a common bacterial disease caused by Pasteurella multocida (P. multocida) and has been reported as a constant serious and highly contagious disease of domestic rabbits (Nassar et al., 2013). Rabbit pasteurellosis causes symptoms that range from fatal septicemia, severe pleuritis, and pneumonia to less severe sequelae such as multiple abscesses, chronic rhinitis, and otitis media. It mostly affects rabbits at 4-8 weeks of age causing manifestations going from lethal septicemia, serious pleuritis, and pneumonia to less extreme sequelae, for example, various abscesses, perpetual rhinitis, and otitis media. The result of any type of the ailment is extreme financial misfortunes. Rabbits older than 8months to 1 year of age showed lower incidence (Mohamed et al., 2019). Pasteurellosis exhibited 3 forms in rabbits. The first one is snuffles or nasal catarrhal inflammation which is characterized by acute, subacute, and chronic inflammation of the air passages and lungs. This form of the disease often ends with death and the cured animals became carriers. The second form is characterized by abscess formation at any part of the body and the case is terminated with septicemia. The last form is characterized by genital infection, which manifests as acute and subacute inflammation of uterus

Efficacy of grape seed hydro‐alcoholic extract in the treatment of experimentally Pasteurella multocida infected rabbits

“…However, infected rabbits treated with GSE revealed a significant decrease in serum ALT, AST, LDH, urea and creatinine levels in contrast to the infected‐non‐treated group. These findings were supported by histopathological findings of liver and kidney that recorded in our previously published paper (El‐Sheikh et al, 2020). These results confirmed the antibacterial activity, hepato‐renal protective effect of GSE that reduced the harmful effects of bacteria on the liver and kidney.…”

“…These findings were supported by histopathological findings of liver and kidney that recorded in our previously published paper (El-Sheikh et al, 2020). These results confirmed the antibacterial activity, hepato-renal protective effect of GSE that reduced the harmful effects of bacteria on the liver and kidney.…”