Efficacy of topical silver against fungal burn wound pathogens

Wright, Jason; Lam, Kei Fong; Hansen, Dennis Schrøder; Burrell, Robert E.

doi:10.1016/s0196-6553(99)70055-6

Cited by 333 publications

(178 citation statements)

References 19 publications

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“…The CPC-fleece was tested against the three bacterial strains in a modified test procedure based on a previously published culture broth method (Thomas & McCubbin, 2003;Wright et al, 1999) and ISO EN 20743 (International Organization for Standardization, 2012), evaluating its direct impact on the microbes, as well as the efficacy of the released CPC only. Pieces of area 1 cm 2 were prepared in an aseptic manner using sterile scissors.…”

mentioning

confidence: 99%

Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations

Fromm‐Dornieden

Rembe

Schäfer

et al. 2015

Journal of Medical Microbiology

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The antimicrobial activity of cetylpyridinium chloride (CPC) and miramistin (MST) solutions at different concentrations (5¾10 "5 to 0.4 %) and a dressing, containing 0.15 % CPC, were tested against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli after 30 (solutions) and 60 min (fleece) incubation, respectively. Furthermore, the cytotoxic effects of CPC and MST were examined in human keratinocyte (HaCaT) and murine fibroblast (L929) cell lines. A dose of 3¾10 "3 % CPC or MST was sufficient to entirely eradicate S. aureus after 30 min incubation. To achieve the same effect, higher concentrations were required against E. coli (0.025 % CPC; 0.0125 % MST) and P. aeruginosa (0.5 % CPC; 0.05 % MST). The CPC-fleece showed a high antiseptic effect against all three bacterial strains, although it did not completely eliminate P. aeruginosa. Both substances showed a high cytotoxic impact at higher tested concentrations (CPC .3¾10 "3 %; MST .8¾10 "4 %). CPC showed high antimicrobial potency at low concentrations against S. aureus, accompanied by low cytotoxic (side) effects at these concentrations, whilst the required minimal concentration to eradicate E. coli and P. aeruginosa was shown to be cytotoxic for keratinocytes and fibroblasts. The necessary antibacterial amounts of MST were lower, but also cytotoxic in direct contact with typical human wound cells. With regard to demographic changes and increasing bacterial resistance, new effective antiseptics, such as CPC and MST, incorporated in wound dressings without releasing an active substance could help to improve the treatment and healing rates of chronic wounds.

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confidence: 99%

Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations

Fromm‐Dornieden

Rembe

Schäfer

et al. 2015

Journal of Medical Microbiology

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“…Silver nanoparticles are effective factor for destroying a wide range of Gram-negative and Gram-positive bacteria. It also has bactericidal activity against strains resistant to antibiotics [24]. Recent studies have shown that the use of silver nanoparticles in combination with certain antibiotics, such as penicillin G, amoxicillin, erythromycin, clindamycin and vancomycin, creates synergies against Escherichia coli or Staphylococcus aureus [25].…”

Section: Discussionmentioning

confidence: 99%

Environmental Aspects of Using Nanomaterials

Banach

Pulit-Prociak

2017

JAPLR

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The paper presents the nanotechnology as a one of main fields of modern science. Since nanotechnology accompanies the everyday life, one should focus on its benefits and disadvantages. Some nanoparticles exhibit animicrobial properties and using them definitely improves the quality of life. Silver nanoparticles are used in many consumer products which serve as antibacterial or antifungal agents. However, due to the fact that the market of nanomaterials is constantly growing, most of living organisms may be exposed on nanoparticles. Silver nanoparticles may be easily accumulated in various organs, such as liver, kidneys, lungs and others. Despite the fact that their activity may not be seen immediately, their impact on living matter may have negative consequences in the future. Hazard and responses issues are raised in the review.

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“…Silver and its various derivatives have been used extensively. (34)(35)(36)(37)(38)(39)(40)(41)(42).…”

Section: Figure 3 Schematic Representation Of Switching Behavior Of mentioning

confidence: 99%

Smart Coatings

Baghdachi

2009

ACS Symposium Series

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Materials that are capable of adapting their properties dynamically to an external stimulus are called responsive, or smart. The term "smart coating" refers to the concept of coatings being able to sense their environment and make an appropriate response to that stimulus. The standard thinking regarding coatings has been as a passive layer unresponsive to the environment. The current trend in coatings technology is to control the coating composition on a molecular level and the morphology at the nanometer scale. The idea of controlling the assembly of sequential macromolecular layers and the development that materials can form defined structures with unique properties is being explored for both pure scientific research and industrial applications. Several smart coating systems have been developed, examined, and are currently under investigation by numerous laboratories and industries throughout the world. Examples of smart coatings include stimuli responsive, antimicrobial, antifouling, conductive, self-healing, and super hydrophobic systems.

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Efficacy of topical silver against fungal burn wound pathogens

Cited by 333 publications

References 19 publications

Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations

Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations

Environmental Aspects of Using Nanomaterials

Smart Coatings

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