Efficacy of apheresis platelets treated with riboflavin and ultraviolet light for pathogen reduction

Abstract

PLTs treated with B2 plus UV light demonstrate some alterations in in vitro measures but retain in vitro and in vivo capabilities similar to pathogen-reduced and licensed PLT components that have been shown to have useful clinical applicability. The recovery, survival, and metabolic properties of Mirasol PLTs should provide sufficient hemostatic support in thrombocytopenia to justify patient clinical trials.

Pathogen-Inaktivierungssysteme für Thrombozytenkonzentrate

“…Glukoseverbrauch eine Korrelation zur Wiederfindung und Überlebensra-te der Thrombozyten in Probanden [118,119].…”

“…Die Transfusion markierter autologer PIbehandelter TK zeigte eine signifikante Verringerung sowohl der Wiederfindungs-als auch der Überlebensrate verglichen mit unbehandelten TK bei allen drei Verfahren [118,140,[145][146][147].…”

Antimicrobial susceptibility of photodynamic therapy (UVA/riboflavin) against Staphylococcus aureus

“…Given that, UV-radiation can cause biosynthesis failures leading to cell death (11) , the application of long-wavelength ultraviolet light (UVA) associated with vitamin B2 (riboflavin), as a photosensitizer, can emerge as an alternative tool for inactivation of bacterial pathogens. Such therapy, has been proposed for inactivation or reduction of the amount of bacterial pathogens from blood components and corneal tissue (12,13) . In order to provide information concerning a potential therapeutic effect on Gram-positive bacterial keratitis, the antimicrobial effect of UVA light in association with B2 against S. aureus strain was evaluated.…”

Pathogen Reduction Technologies: The Best Solution for Safer Blood?

“…After UVC irradiation of PCs HSR decreased by 20-30% but recovered partly during storage [34]. All in all, in vitro quality of UVC irradiated PLTs was shown to be comparable to other PRTs [19,[52][53][54].…”