Pathogen-Inaktivierungssysteme für Thrombozytenkonzentrate

doi:10.1007/s00103-018-2766-3

Cited by 2 publications

(1 citation statement)

References 142 publications

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“…Vergleichbare klinische Studiendaten für den europäischen, nicht-endemischen Raum liegen aktuell nicht vor. Auf der Basis der niedrigen Prävalenz im deutschen Spenderkollektiv und dass eine transfusionsbedingte Übertragung der Malaria auch durch die Anwendung von Pathogenonaktivierungsverfahren nicht zu 100 % verhindert werden kann, kann der generelle Einsatz der Pathogenonaktivierungsverfahren in Deutschland ausschließlich zur Prävention der Transfusionsmalaria aktuell nicht begründet werden [126]. Zudem gibt es derzeit noch keine zugelassenen Pathogenonaktivierungsverfahren für Erythrozytenkonzentrate oder Vollblut.…”

Section: Möglichkeiten Zur Pathogeninaktivierungunclassified

Malaria

2022

Bundesgesundheitsbl

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Section: Möglichkeiten Zur Pathogeninaktivierungunclassified

Malaria

2022

Bundesgesundheitsbl

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West Nile Virus in Germany: An Emerging Infection and Its Relevance for Transfusion Safety

Frank

Schmidt‐Chanasit

Ziegler

et al. 2022

Transfus Med Hemother

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West Nile virus (WNV) is an arthropod-borne virus (arbovirus). It circulates in an enzootic cycle between ornithophilic mosquitoes as vectors and reservoirs and avian host species for amplification, but humans can be infected as accidental hosts. In most individuals, WNV infection remains silent, while 20% develop mild symptoms of West Nile fever, and only 1% develop neuroinvasive disease (WNND). Human WNV cases have been identified in Southern and Eastern Europe for more than 20 years, but until 2018, Germany was considered to be a non-endemic country. This changed when in the exceptionally warm summer of 2018, conditions for viral replication in mosquitoes were ideal, and the first WNV cases among birds and horses were identified. The widespread domestic <i>Culex</i>mosquitoes are efficient vectors for WNV. Autochthonous mosquito-borne WNV infections in humans were reported in all following years, indicating a continuous circulation in the affected areas of Central-East Germany. So far, no clear expansion of the affected areas is discernible but may develop. WNV is a transfusion-transmissible-infection, and donor deferral or testing of donations after a stay in an affected area are effective means to ensure transfusion safety. WNV transmissions via blood products often result in WNND due to the predisposing underlying medical conditions of transfusion recipients. From 2020 onwards, roughly 80% of all blood establishments in Germany tested their donations for WNV using nucleic acid amplification techniques in the transmission season. Altogether, 19 confirmed WNV infections were identified from 2020–2021. As long as effective and affordable pathogen reduction is not available for all blood components, WNV testing or donor deferral will be essential. In order to timely identify affected areas, combined results of human and veterinary surveillance are needed. Partnerships between public health experts, transfusion medicine specialists, veterinarians, and entomologists should be strengthened to ensure a One Health approach.

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Pathogen-Inaktivierungssysteme für Thrombozytenkonzentrate

Cited by 2 publications

References 142 publications

Malaria

Malaria

West Nile Virus in Germany: An Emerging Infection and Its Relevance for Transfusion Safety

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