Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis

Kathpalia, Meghavi; Mishra, Pinki; Bajpai, Ram; Bhurani, Dinesh; Agarwal, Nidhi

doi:10.1007/s00277-022-04880-1

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…Nevertheless, it can be inhibited by pathway inhibitors in leukemia models [45]. The nucleoside analogue nelarabine has proven to show early activity in patients with relapsed/refractory T-ALL, but it was associated with neurotoxicity [46]. The proteasome inhibitor, bortezomib was examined in the Children's Oncology Group phase III clinical trial AALL123, in which only patients with T-lymphoblastic lymphoma showed a significantly improved survival [47].…”

Section: Molecular Basis Of Acute Lymphoblastic Leukemiamentioning

confidence: 99%

Proteomics in Childhood Acute Lymphoblastic Leukemia: Challenges and Opportunities

Kourti,

Aivaliotis,

Hatzipantelis

2023

Diagnostics

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Acute lymphoblastic leukemia (ALL) is the most common cancer in children and one of the success stories in cancer therapeutics. Risk-directed therapy based on clinical, biologic and genetic features has played a significant role in this accomplishment. Despite the observed improvement in survival rates, leukemia remains one of the leading causes of cancer-related deaths. Implementation of next-generation genomic and transcriptomic sequencing tools has illustrated the genomic landscape of ALL. However, the underlying dynamic changes at protein level still remain a challenge. Proteomics is a cutting-edge technology aimed at deciphering the mechanisms, pathways, and the degree to which the proteome impacts leukemia subtypes. Advances in mass spectrometry enable high-throughput collection of global proteomic profiles, representing an opportunity to unveil new biological markers and druggable targets. The purpose of this narrative review article is to provide a comprehensive overview of studies that have utilized applications of proteomics in an attempt to gain insight into the pathogenesis and identification of biomarkers in childhood ALL.

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Section: Molecular Basis Of Acute Lymphoblastic Leukemiamentioning

confidence: 99%