Effects of Vitamin D treatment on thyroid autoimmunity

Şimşek, Yasin; Cakir, Ilkay; Yetmiş, Mikail; Dizdar, Oğuzhan Sıtkı; Başpınar, Osman; Gökay, Ferhat

doi:10.4103/1735-1995.192501

Cited by 44 publications

(27 citation statements)

References 31 publications

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“…These findings suggest that VD is associated with the pathogenesis and development of AITD. 178 – 188 A VD deficiency has been proposed to increase the immune response through activating the production of autoimmune thyroid antibodies in T helper-2 cells (Th-2) and B cells. 189 , 190 …”

Section: Environmental Factors and Autoimmunitymentioning

confidence: 99%

Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Li¹,

Liu

2020

Therapeutic Advances in Endocrinology

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Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.

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Section: Environmental Factors and Autoimmunitymentioning

confidence: 99%

Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Li¹,

Liu

2020

Therapeutic Advances in Endocrinology

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“…The number of responders (≥25% fall in anti-TPO level) was higher in the group that received vitamin D supplementation (68% vs. 44%; p = 0.015) [ 42 ]. Simsek et al, demonstrated that anti-TPO and anti-Tg levels in AITD patients with a 25(OH)D level <50 nmol/L were significantly decreased as a result of administration of vitamin D at 1000 IU/day for 1 month ( p = 0.02 and p = 0.03, respectively) [ 43 ].…”

Section: Vitamin D and Autoimmune Thyroid Diseasesmentioning

confidence: 99%

The Role of Vitamin D in Thyroid Diseases

Kim

2017

IJMS

178

144

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The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases such as Hashimoto’s thyroiditis and Graves’ disease, and impaired vitamin D signaling has been reported in thyroid cancers. This review will focus on recent data on the possible role of vitamin D in thyroid diseases, including autoimmune thyroid diseases and thyroid cancers.

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“…Several other studies also reported similar results regarding the inverse association between Vitamin D level and AITDs. [ 26 27 28 29 30 ]…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D deficiency treatment on thyroid function and autoimmunity markers in hashimoto's thyroiditis: A double-blind randomized placebo-controlled clinical trial

et al. 2017

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Background:The link between autoimmune thyroid diseases and Vitamin D deficiency has been reported. However, there are controversies in this regard. We conducted a double-blind randomized placebo-controlled clinical trial to investigate the effect of Vitamin D deficiency treatment on thyroid function and autoimmunity marker (thyroid peroxidase antibody [TPO-Ab]) in patients with Hashimoto's thyroiditis.Materials and Methods:Fifty-six patients with Hashimoto's thyroiditis and Vitamin D deficiency (25-hydroxyvitamin D level ≤20 ng/mL) were randomly allocated into two groups to receive Vitamin D (50000 IU/week, orally) or placebo for 12 weeks, as Vitamin D-treated (n = 30) and control (n = 26) groups, respectively. TPO-Ab, thyroid-stimulating hormone (TSH), parathormone, calcium, albumin, and creatinine concentrations were compared before and after trial between and within groups. The data were presented as mean (standard error [SE]) and analyzed by appropriate tests.Results:Mean (SE) of Vitamin D was increased in Vitamin D-treated group (45.5 [1.8] ng/mL vs. 12.7 [0.7] ng/mL, P = 0.01). Mean (SE) of TPO-Ab did not significantly change in both groups (734 [102.93] IU/mL vs. 820.25 [98.92] IU/mL, P = 0.14 in Vitamin D-treated and 750.03 [108.7] [IU/mL] vs. 838.07 [99.4] [IU/mL] in placebo-treated group, P = 0.15). Mean (SE) of TSH was not changed in both groups after trial, P = 0.4 and P = 0.15 for Vitamin D-treated and control groups, respectively. No significant difference was observed between two study groups in none studied variables (P > 0.05).Conclusion:Vitamin D treatment in Vitamin D deficient patients with Hashimoto's thyroiditis could not have significant effect on thyroid function and autoimmunity.

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Effects of Vitamin D treatment on thyroid autoimmunity

Cited by 44 publications

References 31 publications

Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

The Role of Vitamin D in Thyroid Diseases

Effect of vitamin D deficiency treatment on thyroid function and autoimmunity markers in hashimoto's thyroiditis: A double-blind randomized placebo-controlled clinical trial

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