Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Li, Liyan; Liu, Shudong; Yu, Junxia

doi:10.1177/2042018820958329

Cited by 23 publications

(41 citation statements)

References 252 publications

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“…The study was conducted to assess the correlation between the occurrence of AITD and the development of DKD. AITD and DM1 are common autoimmune diseases [ 17 ]. AITD occurs in 17–30% of DM1 patients, and approximately 25% of children with DM1 have antithyroid antibodies (ATA) at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Stefanowicz-Rutkowska

Matuszewski

Gontarz-Nowak

et al. 2021

Open Life Sciences

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Autoimmune thyroid disease (AITD) is more common among diabetes mellitus (DM) patients and may impact its microvascular complications. The present study aimed to assess the relationship between AITD and the prevalence of diabetic kidney disease (DKD) in patients with diabetes mellitus type 1 (DM1). Anthropometric parameters, parameters of metabolic control of DM, thyreometabolic status, and the UACR were assessed. DKD was diagnosed if patients’ UACR level was ≥30 mg/g or eGFR level was <60 mL/min. This study involved 144 patients with DM1 aged 36.2 ± 11.7 years: 49 men and 95 women. Significant differences in creatinine, eGFR, and UACR levels were found in patients with DKD. fT3 concentration was significantly lower among DKD patients. A significantly higher probability of DKD was found in DM1 patients with lower fT3 levels. Patients with DM1 and AITD had significantly lower creatinine levels than the control group. However, the study did not show any significant relationship between AITD and the occurrence of DKD in patients with DM1. Significantly lower fT3 concentrations in DKD patients may be caused by metabolic disorders in the course of DKD and require further cohort studies in a larger population of patients with DM1 and AITD.

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Section: Discussionmentioning

confidence: 99%

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Stefanowicz-Rutkowska

Matuszewski

Gontarz-Nowak

et al. 2021

Open Life Sciences

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show abstract

“…T lymphocytes in ltrate the glands, then subsequent development of various degrees of thyroid dysfunction. 7 Thyroid hormones T4 and T3 were produced by a glycosylated transmembrane protein named thyroid peroxidase, which is distributed in the apical part of follicular thyroid cells. 13 Metabolomics techniques have shown that people who develop diabetes have different levels of certain lipids when compared with people who remain non-diabetic.…”

Section: Discussionmentioning

confidence: 99%

“…Autoimmune thyroid disease (AITD) and T1DM are two common autoimmune diseases and can occur concomitantly. 7 Many studies have demonstrated that changes in serum thyroid hormone parameters are associated with diabetes. A study concluded that thyroid hormone parameters seemed to re ect the effects of a prolonged period of catabolism, DKA, or both.…”

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confidence: 99%

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Correlation of serum vitamin D level with ketoacidosis in Chinese children with type 1 diabetes mellitus

Shu

Wang

Zhang

et al. 2021

Preprint

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Objective: Diabetic ketoacidosis is a common complication in children with type 1 diabetes mellitus. The purposes of the present study were to explore clinical correlates of serum vitamin D level in Chinese children with type 1 diabetes.Methods: A total of 143 inpatients (boys/girls = 60/83) were recruited from Tianjin Children’s Hospital. Their demographic and clinical characteristics were collected. These patients were divided into the non-DKA group(n=43) and DKA group(n=100).Results: The positive ZnT8-ab was significantly higher in DKA patients compared with non-DKA patients (p=0.038). There was a negative correlation between plasma glucose and the concentration of vitamin D(r =−0.188, p=0.024), although there was no significant difference in vitamin D between two groups of T1DM patients with or without DKA (p=0.317). The multiple logistic regression revealed that sex(male) and BMI were independent risk factors to predict the deficiency or insufficiency of Vitamin D in T1DM children. When BMI is lower than 16 kg/m2 according to the cut-off value of the ROC curve, it provides some implications of Vitamin D deficiency or insufficiency in TIDM children ( 95%CI:0.534~0.721, P=0.014). Conclusions: Our results suggested that positive ZnT8-ab was associated with a greater risk of DKA at T1DM onset. Additionally, neither vitamin D levels nor the proportion of patients with different levels of vitamin D differed between the two groups inT1DM children with or without DKA. Furthermore, Vitamin D level was negatively correlated with plasma glucose, lower BMI and male children with T1DM were prone to be deficient or insufficient of Vitamin D.

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“…The pathogenesis of AITD involves cellular and humoral autoimmune mechanisms against the thyroid gland. T lymphocytes in ltrate the glands, then subsequent development of various degrees of thyroid dysfunction [22] . Thyroid hormones T4 and T3 were produced by a glycosylated transmembrane protein named thyroid peroxidase, which is distributed in the apical part of follicular thyroid cells [23] .Metabolomics techniques have shown that people who develop diabetes have different levels of certain lipids when compared with people who remain non-diabetic [24] .In addition, thyroid dysfunction can lead to metabolic disorders.…”

Section: 62±342 Years)mentioning

confidence: 99%

Association of Triglyceride-Glucose Index with the Incidence of Ketoacidosis in Chinese Children with Type 1 Diabetes

Gao

Wang

Shu

et al. 2021

Preprint

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Objective: The relationship between triglyceride-glucose index (TyG index) and the prevalence of type 2 diabetes mellitus (T2DM) has been confirmed by former studies. However, it remains uncertain whether TyG index has a predictive value in T1DM patients with diabetic ketoacidosis (DKA).Methods: The study retrospectively enrolled 143 patients ((boys/girls = 60/83) with T1DM in the Endocrine inpatient wards of Tianjin Children’s Hospital from June 2017 to May 2019.TyG index was calculated as follows: ln[fasting triglycerides (mg/dL)×fasting plasma glucose (mg/dL)/2]. These patients stratifed by the optimal cut-off point of TyG index were divided into the lower TyG index group (n=73) and higher TyG index group (n=70).Results: TyG index and related lipid parameters were significantly higher in patients with DKA compared with those without. Compared with patients in lower TyG index group, those with higher TyG index seemed to be younger. Multiple linear regression analysis showed that increase of TC (95%CI: 0.018~0.568, p=0.037) level and decrease of T3(95%CI:-2.314~-0.668,p=0.001) level were associated with the risk of higher TyG index. A linear equation was obtained between TC, T3 and TyG index (TyG index=10.226+0.299*TC-1.384*T3, R2=0.481). Conclusions: Increased TyG index is a significant predictor of DKA in children with T1DM. Higher TC and lower T3 levels were associated with higher TyG index. Further studies need to be conducted to determine whether interventions for TyG index have a positive impact on improving clinical prognosis.

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Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Cited by 23 publications

References 252 publications

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Correlation of serum vitamin D level with ketoacidosis in Chinese children with type 1 diabetes mellitus

Association of Triglyceride-Glucose Index with the Incidence of Ketoacidosis in Chinese Children with Type 1 Diabetes

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Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

Cited by 23 publications

References 252 publications

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Is there a relationship between the prevalence of autoimmune thyroid disease and diabetic kidney disease?

Correlation of serum vitamin D level with ketoacidosis in Chinese children with type 1 diabetes mellitus

Association of Triglyceride-Glucose&nbsp;Index&nbsp;with the Incidence of Ketoacidosis in Chinese Children with Type 1 Diabetes

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Association of Triglyceride-Glucose Index with the Incidence of Ketoacidosis in Chinese Children with Type 1 Diabetes