Effect of vitamin D deficiency treatment on thyroid function and autoimmunity markers in hashimoto's thyroiditis: A double-blind randomized placebo-controlled clinical trial

Anaraki, Parichehr Vahabi; Aminorroaya, Ashraf; Amini, Massoud; Momeni, Fatemeh; Feizi, Awat; Iraj, Bijan; Tabatabaei, Azamosadat

doi:10.4103/jrms.jrms_1048_16

Cited by 21 publications

(12 citation statements)

References 33 publications

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“…After reviewing the full text of 24 articles, eight eligible randomized controlled trials were included in the meta-analysis. [7][8][9][10][11][12][13][14] The study characteristics are shown in Table 1. [7][8][9][10][11][12][13][14] These eight studies involved 652 patients with HT, including 332 in the intervention groups and 320 in the control groups.…”

Section: Resultsmentioning

confidence: 99%

“…[7][8][9][10][11][12][13][14] The study characteristics are shown in Table 1. [7][8][9][10][11][12][13][14] These eight studies involved 652 patients with HT, including 332 in the intervention groups and 320 in the control groups. All were published between 2015 and 2020, with study periods ranging from 4 to 24 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…Figure2. Risk of bias graph and summary of bias assessment of the eight randomized controlled trials included in a meta-analysis of the effect of vitamin D supplementation on thyroid autoimmunity markers in patients with Hashimoto's thyroiditis (HT) [7][8][9][10][11][12][13][14]. The colour version of this figure is available at: http://imr.sagepub.com.…”

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confidence: 99%

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Effects of vitamin D on thyroid autoimmunity markers in Hashimoto’s thyroiditis: systematic review and meta-analysis

Zhang

Chen

et al. 2021

J Int Med Res

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Objective To perform a meta-analysis of randomized controlled trials to evaluate the efficacy of vitamin D supplementation on thyroid autoimmunity markers in Hashimoto’s thyroiditis (HT). Methods This meta-analysis included randomized controlled clinical trials identified by a systematic search of electronic databases (PubMed®, MEDLINE®, EMBASE, The Cochrane Library, China National Knowledge Infrastructure) from inception to August 2020. All studies included patients with HT that received vitamin D supplementation irrespective of the doses administered or the duration of treatment. The primary and secondary outcome measures were thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TGAb) titres. Results Eight studies ( n = 652) were included. There was significant heterogeneity between the studies. Using a random-effect model, vitamin D supplementation reduced TPOAb titre (standardized mean difference [SMD]: –1.11; 95% confidence interval [CI]: 1–1.92, –0.29) and TGAb titre (SMD: –1.12; 95% CI: –1.96, –0.28). A subgroup analysis demonstrated that vitamin D supplementation for >3 months resulted in a decrease in TPOAb titre (SMD: –1.66, 95% CI: –2.91, –0.41) but treatment ≤3 months was ineffective. Treatment with vitamin D3 decreased TPOAb titre (SMD: –1.48; 95% CI: –2.53, –0.42) whereas vitamin D did not. Conclusion These data suggest that vitamin D reduces autoantibody titre in patients with HT.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effects of vitamin D on thyroid autoimmunity markers in Hashimoto’s thyroiditis: systematic review and meta-analysis

Zhang

Chen

et al. 2021

J Int Med Res

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“…Clinical trials investigating the effect of vitamin D supplementation in AITD are limited and inconclusive. While some of them suggested the significant reduction in thyroid auto-antibodies levels (thyroperoxidase autoantibody (TPO-Ab) and thyroglobulin autoantibody (TgAb)) and the improvement in thyroid function tests (thyroid-stimulating hormone (TSH) and Free Thyroxine (FT4) levels) with vitamin D supplementation in AITD patients [ 219 , 220 ], others showed no effect of vitamin D treatment on thyroid function and autoimmunity in AITD patients [ 221 ].…”

Section: Molecular and Clinical Studies Of Vitamin D In Various Dimentioning

confidence: 99%

Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies

Umar

Sastry

Chouchane

2018

IJMS

172

151

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The classical function of Vitamin D, which involves mineral balance and skeletal maintenance, has been known for many years. With the discovery of vitamin D receptors in various tissues, several other biological functions of vitamin D are increasingly recognized and its role in many human diseases like cancer, diabetes, hypertension, cardiovascular, and autoimmune and dermatological diseases is being extensively explored. The non-classical function of vitamin D involves regulation of cellular proliferation, differentiation, apoptosis, and innate and adaptive immunity. In this review, we discuss and summarize the latest findings on the non-classical functions of vitamin D at the cellular/molecular level and its role in complex human diseases.

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“…Beside levothyroxine, some medications like supplementations or plants are used to help the treatment of hypothyroidism. These components could decrease the peripheral hypothyroidism symptoms or increase the production of related hormones (6)(7)(8). Although the well-known hypothyroidism medication, levothyroxine, shows an excellent efficacy, it causes different side effects like tachycardia, heat intolerance and tremor (9).…”

Section: Introductionmentioning

confidence: 99%

The effects of Urtica dioica hydroalcoholic extract on the propylthiouracil induced hypothyroidism in rat

Abdolhosseinipoor¹,

Dinani²,

Hosseini-Sharifabad³

2018

J Herbmed Pharmacol

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The extract of Urtica dioica, in some especial doses reversed the PTU-induced T 3 diminution. The results show that it might be effective in hypothyroidism disease.Please cite this paper as: Abdolhosseinipoor F, Sadeghi-Dinani M, Hosseini-Sharifabad A. The effects of Urtica dioica hydroalcoholic extract on the propylthiouracil induced hypothyroidism in rat. Introduction:Hypothyroidism is an important endocrine disorder determined by some depressed symptoms. Urtica dioica (Urticaceae) is a medicinal plant which has been traditionally used for treatment of a wide range of decreased functions of different organs. In the current study, we aimed to evaluate the effect of hydroalcoholic extract of aerial parts of U. dioica on thyroid hormones in propylthiouracil (PTU)-induced hypothyroidism in rats. Methods: Forty-two male Wistar rats were randomly divided into 7 groups including control, PTU, different doses of Urtica dioica hydroalcoholic extract (UDHAE) treated and levothyroxine treated groups. The animals in various groups received water (control group) or water containing 0.1% W/V PTU and then injected saline (control group) or 25, 50, 100, 150 mg/kg UDHAE, respectively for 4 weeks. Positive control group was fed levothyroxine 0.5 mg/kg during the PTU treatment. Then, the blood samples were collected and the levels of thyroxine (T 4 ), triiodothyronine (T 3 ), free triiodothyronine (FT 3 ) and thyroid-stimulating hormone (TSH) measured via the Elisa method. Results: The data showed that PTU decreased the blood level of thyroid hormones but increased TSH, significantly. The 50 or 100 mg/kg doses of UDHAE remarkably increased the blood level of T 3 and FT 3 . The 50 mg/kg doses of UDHAE increased the blood level of T 4 . None of the UDHAE doses showed significant change in the TSH levels. 25 and 150 mg/kg doses of UDHAE did not change the PTU-diminished level of thyroid related hormones. Conclusion: The findings suggest that 50 mg/kg dose of UDHAE has stimulatory effect on thyroid gland function and raises plasma T 3 & T 4 & FT 3 levels. UDHAE at the dose of 50 or 100 mg/kg could enhance blood level of T 3 and FT 3 perhaps by increase in T 4 to T 3 transformation. Higher doses of UDHAE could not increase the level of these hormones probably due to the presence of inhibitory materials.

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Effect of vitamin D deficiency treatment on thyroid function and autoimmunity markers in hashimoto's thyroiditis: A double-blind randomized placebo-controlled clinical trial

Cited by 21 publications

References 33 publications

Effects of vitamin D on thyroid autoimmunity markers in Hashimoto’s thyroiditis: systematic review and meta-analysis

Effects of vitamin D on thyroid autoimmunity markers in Hashimoto’s thyroiditis: systematic review and meta-analysis

Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies

The effects of Urtica dioica hydroalcoholic extract on the propylthiouracil induced hypothyroidism in rat

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