Effects of vitamin D on thyroid autoimmunity markers in Hashimoto’s thyroiditis: systematic review and meta-analysis

Zhang, Jingwen; Chen, Yuting; Li, Hongyan; Li, Hong

doi:10.1177/03000605211060675

Cited by 20 publications

(20 citation statements)

References 33 publications

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“…On the other hand, a small number of studies,showed no significant association between AITDs and vitamin D deficiency [ 14 – 17 ]. These pieces of evidence led several researchers to examine the effectiveness of vitamin D supplementation in the prevention/treatment of this group of conditions [ 18 , 19 ]. The results are conflicting, so the potential of vitamin D in thyroid diseases treatmentneeds to be clarified.…”

Section: Introductionmentioning

confidence: 99%

“…To our knowledge, no published study has evaluated the quality of RCTs for vitamin D supplement in thyroidautoimmunity based on the CONSORT statement. The most recent study published in December 2021 was a meta-analysis focusing on cases of Hashimoto disease and the evaluation was conducted using the Cochrane CollaborationRisk of Bias tool Statistical analysis [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the reporting quality of randomised controlled trials for vitamin D supplementation in autoimmune thyroid disorders based on the CONSORT statement

et al. 2022

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Background—Purpose Randomized controlled trials (RCTs) are the cornerstone of evidence-based medicine, yet their quality is often suboptimal. The Consolidated Standards of Reporting Trials (CONSORT) statement is a list of advice to upgrade the quality of RCTs. The aim of this study was the assessment of the quality of RCTs for vitamin D supplements in thyroid autoimmunity according to the revised CONSORT 2010 checklist. Methods Databases were searched for RCTs involving patients with autoimmune thyroid disorders (AITDs) who received vitamin D supplements published from 2011 to 2021. A list of 37-items was used and adherence ≥75% was considered of optimal quality. The primary outcome was the mean CONSORT adherence of studies. Secondary outcomes were the estimation of compliance per CONSORT item and the examination for possible determinants of the reporting quality. Results Thirteen eligible trials were finally included. The mean compliance was 61.15% ± 14.86%. Only threeof the studies (23%) achieved a good reporting quality (≥75%), while ten (77%) were presented with inadequate reporting (<75%). Randomization and blinding were mainly poorly reported. Impact Factor (IF) of journal was associated with the reporting quality in the univariate analysis [ p = 0.033, OR = 1.65, 95%CI = (1316, 1773)]. Sample size ( p = 0.067), number of authors ( p = 0.118) and number of citations ( p = 0.125) were marginally not significant. None of the factors showed significant results in multivariate analysis. Reporting quality and IF were strongly positively correlated [Pearson’s r = 0.740, p = 0.04]. Conclusion This study shows that mean CONSORT adherence of RCTs for Vitamin D supplementation in AITDs is moderate, reflecting that study quality and transparency could be improved with better adherence to CONSORT rules.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of the reporting quality of randomised controlled trials for vitamin D supplementation in autoimmune thyroid disorders based on the CONSORT statement

et al. 2022

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“…A systematic review and meta-analysis from 2021 which included 8 studies (n = 652) also suggests that vitamin D supplementation for >three months reduces autoantibody titers in patients with HT, although treatment ≤3 months was ineffective [ 32 ]. Another recent systematic review and meta-analysis which included six randomized controlled trials with 330 HT patients also showed that after six months of vitamin D supplementation, TPOAb and TgAb levels significantly decreased as compared with the control group.…”

Section: Micronutrients In Htmentioning

confidence: 99%

“…On the other hand, inadequate dietary Se intake may exacerbate HT [ 2 , 4 , 7 ]. Moreover, recent data demonstrated that vitamin D supplementation may have a beneficial effect on the course of HT [ 27 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview

Mikulska

Karaźniewicz−Łada

Filipowicz

et al. 2022

IJMS

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Hashimoto’s thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism, in which damage to the thyroid gland occurs due to the infiltration of lymphocytes. It is characterized by increased levels of antibodies against thyroid peroxidase and thyroglobulin. In this review, we present the metabolic profile, the effectiveness of micronutrient supplementation and the impact of dietary management in patients with HT. For this current literature review, the databases PubMed, Cochrane, Medline and Embase were reviewed from the last ten years until March 2022. This article provides a comprehensive overview of recent randomized controlled trials, meta-analyses, and clinical trials. Many patients with HT, even in the euthyroid state, have excess body weight, metabolic disorders, and reduced quality of life. Due to frequent concomitant nutritional deficiencies, the role of vitamin D, iodine, selenium, magnesium, iron and vitamin B12 is currently debated. Several studies have underlined the benefits of vitamin D and selenium supplementation. There is still no specific diet recommended for patients with HT, but a protective effect of an anti-inflammatory diet rich in vitamins and minerals and low in animal foods has been suggested. There is insufficient evidence to support a gluten-free diet for all HT patients. Pharmacotherapy, along with appropriate nutrition and supplementation, are important elements of medical care for patients with HT. The abovementioned factors may decrease autoantibody levels, improve thyroid function, slow down the inflammatory process, maintain proper body weight, relieve symptoms, and prevent nutritional deficiencies and the development of metabolic disorders in patients with HT.

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“…To the best of our knowledge, the reviews or meta-analyses conducted so far have focused on the importance of selected nutrients in Hashimoto’s disease, i.e., selenium, vitamin D, iodine, gluten, zinc, iron, and goitrogens [ 8 , 10 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. However, current clinical evidence of the effect of the dietary factors on HT is still scanty and inconclusive.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

Osowiecka

Myszkowska-Ryciak

2023

Nutrients

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Diet can be a complementary treatment for Hashimoto’s disease by affecting thyroid function and anti-inflammatory properties. It is still unclear which dietary strategy would be the most beneficial. The aim of this systematic review is to examine all the data currently available in the literature on the effects of nutritional intervention on biochemical parameters (anti-thyroid antibody and thyroid hormones levels) and characteristic symptoms in the course of Hashimoto’s thyroiditis. This systematic review was prepared based on PRISMA guidelines. Articles in PubMed and Scopus databases published up to November 2022 were searched. As a result of the selection, out of 1350 publications, 9 were included for further analysis. The nutritional interventions included the following: elimination of gluten (3 articles) or lactose (1 article), energy restriction with or without excluding selected foods (n = 2), consumption of Nigella sativa (n = 2), or dietary iodine restriction (n = 1). The intervention duration ranged from 21 days to 12 months and included individuals with various thyroid function. Of the nine studies, three studies were female only. An improvement was observed during an energy deficit and after the elimination of selected ingredients (e.g., gluten, lactose, or goitrogens), as well as after the intervention of Nigella sativa. These interventions improved antibody levels against peroxidase (anti-TPO), (thyrotropin) TSH, and free thyroxine (fT4). No improvement was seen on the iodine-restricted diet. Varied outcomes of analyzed dietary interventions may be due to the heterogeneous thyroid condition, high variability between patients, and differences in habitual intake of critical nutrients (e.g., iodine, selenium, and iron) in different populations. Therefore, there is a great need for further experimental studies to determine whether any nutritional interventions are beneficial in Hashimoto’s disease.

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Effects of vitamin D on thyroid autoimmunity markers in Hashimoto’s thyroiditis: systematic review and meta-analysis

Cited by 20 publications

References 33 publications

Assessment of the reporting quality of randomised controlled trials for vitamin D supplementation in autoimmune thyroid disorders based on the CONSORT statement

Assessment of the reporting quality of randomised controlled trials for vitamin D supplementation in autoimmune thyroid disorders based on the CONSORT statement

Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview

The Influence of Nutritional Intervention in the Treatment of Hashimoto’s Thyroiditis—A Systematic Review

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