Effects of the combination of low-level laser therapy and anionic polymer membranes on bone repair

Santos, Daniel Alves dos; Plepis, Ana Maria de Guzzi; Martins, Virgínia da Conceição Amaro; Cardoso, Guinéa Brasil Camargo; Santos, Arnaldo Rodrigues; Iatecola, Amilton; Andrade, Tiago Neves; Monteiro, Fabrício Moreira; Calegari, Amanda Regina Alves; Chacon, Erivelto Luís; Cunha, Marcelo Rodrigues da

doi:10.1007/s10103-019-02864-8

Cited by 10 publications

(3 citation statements)

References 37 publications

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“…The collagen matrix was derived from bovine intestinal serosa and the elastin matrix from bovine auricular cartilage. The manufacturing process of matrices and their characterizations have been described in detail in previously published studies [ 16 , 27 , 28 , 29 , 30 , 31 , 32 ]. In summary, the bovine serosa and auricular cartilage were washed exhaustively in 0.9% saline (NaCl) and distilled water.…”

Section: Methodsmentioning

confidence: 99%

In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats

et al. 2022

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The aim of the present study was to evaluate the use of collagen, elastin, or chitosan biomaterial for bone reconstruction in rats submitted or not to experimental alcoholism. Wistar male rats were divided into eight groups, submitted to chronic alcohol ingestion (G5 to G8) or not (G1 to G4). Nasal bone defects were filled with clot in animals of G1 and G5 and with collagen, elastin, and chitosan grafts in G2/G6, G3/G7, and G4/G8, respectively. Six weeks after, all specimens underwent radiographic, tomographic, and microscopic evaluations. Bone mineral density was lower in the defect area in alcoholic animals compared to the abstainer animals. Bone neoformation was greater in the abstainer groups receiving the elastin membrane and in abstainer and alcoholic rats receiving the chitosan membrane (15.78 ± 1.19, 27.81 ± 0.91, 47.29 ± 0.97, 42.69 ± 1.52, 13.81 ± 1.60, 18.59 ± 1.37, 16.54 ± 0.89, and 37.06 ± 1.17 in G1 to G8, respectively). In conclusion, osteogenesis and bone density were more expressive after the application of the elastin matrix in abstainer animals and of the chitosan matrix in both abstainer and alcoholic animals. Chronic alcohol ingestion resulted in lower bone formation and greater formation of fibrous connective tissue.

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Section: Methodsmentioning

confidence: 99%

In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats

et al. 2022

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“…The manufacturing process of elastin and collagen matrices and their characterizations have been described in greater detail in previously published studies [7,19,27,[40][41][42]. The elastin matrices used were prepared by the Biochemistry and Biomaterials Group of the São Carlos Institute of Chemistry (University of São Paulo-USP, Brazil) by adapting the methodology used to obtain collagen [7,8,14].…”

Section: Elastin Matrix Derived From Bovine Auricular Cartilagementioning

confidence: 99%

In Vivo Biological Behavior of Polymer Scaffolds of Natural Origin in the Bone Repair Process

et al. 2021

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Autologous bone grafts, used mainly in extensive bone loss, are considered the gold standard treatment in regenerative medicine, but still have limitations mainly in relation to the amount of bone available, donor area, morbidity and creation of additional surgical area. This fact encourages tissue engineering in relation to the need to develop new biomaterials, from sources other than the individual himself. Therefore, the present study aimed to investigate the effects of an elastin and collagen matrix on the bone repair process in critical size defects in rat calvaria. The animals (Wistar rats, n = 30) were submitted to a surgical procedure to create the bone defect and were divided into three groups: Control Group (CG, n = 10), defects filled with blood clot; E24/37 Group (E24/37, n = 10), defects filled with bovine elastin matrix hydrolyzed for 24 h at 37 °C and C24/25 Group (C24/25, n = 10), defects filled with porcine collagen matrix hydrolyzed for 24 h at 25 °C. Macroscopic and radiographic analyses demonstrated the absence of inflammatory signs and infection. Microtomographical 2D and 3D images showed centripetal bone growth and restricted margins of the bone defect. Histologically, the images confirmed the pattern of bone deposition at the margins of the remaining bone and without complete closure by bone tissue. In the morphometric analysis, the groups E24/37 and C24/25 (13.68 ± 1.44; 53.20 ± 4.47, respectively) showed statistically significant differences in relation to the CG (5.86 ± 2.87). It was concluded that the matrices used as scaffolds are biocompatible and increase the formation of new bone in a critical size defect, with greater formation in the polymer derived from the intestinal serous layer of porcine origin (C24/25).

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“…Controlar suas propriedades mecânicas e taxas de degradação se torna difícil, e existe o potencial de um polímero natural causar uma resposta imune ou transportar vírus ou micróbios (Song et al, 2018). Vários estudos estão sendo realizados com polímeros sintéticos para evitar os efeitos potenciais de longo prazo associados aos polímeros não degradáveis, como cicatrizes, inflamação e além disso esses estudos estão sendo bastantes direcionados na área de engenharia de tecido para aplicação na regeneração do tecido ósseo sem qualquer complicação, fazendo-se necessário o uso de um polímero sintético, pois provomem o crescimento e a proliferação de células ósseas, é biocompativel, tem que foi sintetizado com materiais bioativos que imitam as células ósseas para uma melhor adesão ao tecido lesionado, podendo atuar no processo de regeneração do tecido ósseo, ainda ser reabsorvido e substituído pelo tecido recém-formado (Bharadwaz & Jayasuriya, 2020;George, Sanjay, Srisuk, Parameswaranpillai, & Siengchin, 2020;Santos et al, 2020). Os polímeros biodegradáveis são uma classe de polímero que vem crescendo bastante, pois sua degradação resulta da ação de micro-organismos de ocorrência natual, essa decomposição pode ocorrer em semanas ou até meses sob condições favoráveis para a ocorrência da decomposição (Filho, Luna, Siqueira, Araújo, & Wellen, 2020).…”

Section: Introductionunclassified

Estudo sobre a utilização de polianidrido como abordagem terapêutica para o tratamento de lesões no tecido ósseo

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Silva

Filho

et al. 2021

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O polianidrido (PA) é um polímero sintético, biodegradável, que possui um mecanismo de erosão que se torna bem útil na aplicação de regeneração do tecido ósseo. O presente trabalho teve por objetivo avaliar a evolução das publicações cientificas relacionadas aos polianidridos biodegradáveis com a sua aplicação em regeneração do tecido ósseo. Foram realizadas buscas nas bases de periódicos Web of Science e Scopus a partir da combinação de palavras-chave, e os resultados reportados nas bases foram tabulados. Verificou-se que o número de publicações se deu no horizonte temporal de 1993 a 2019, com maior número de publicações pertencente aos Estados Unidos. Constatou-se também que farmacologia, toxicologia e farmacêutica (18%), imunologia e microbiologia (13%) e engenharia química (13%) foram as áreas de maior destaque, sendo que 46% das publicações são referentes a artigos originais e 39% a artigos de revisão. O alto impacto das publicações nessa área foi evidenciado pelo número crescente de citações, reforçando a produtividade e notoriedade da temática diante dos pesquisadores. Pode-se concluir, portanto, que essa é uma área de pesquisa que vem obtendo notório crescimento, evidenciando seu caráter promissor.

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Effects of the combination of low-level laser therapy and anionic polymer membranes on bone repair

Cited by 10 publications

References 37 publications

In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats

In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats

In Vivo Biological Behavior of Polymer Scaffolds of Natural Origin in the Bone Repair Process

Estudo sobre a utilização de polianidrido como abordagem terapêutica para o tratamento de lesões no tecido ósseo

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