Effects of Sunset Yellow FCF on immune system organs during different chicken embryonic periods

Abstract

IntroductionSunset Yellow FCF (SY), used frequently in ready-made foods, cosmetics, and the pharmaceutical industry, may cause many health problems. This study is intended to evaluate the morphological and cellular effects of SY on the embryonic chicken immune system throughout incubation.Material and MethodsBabcock white leghorn eggs were randomly divided into four groups. Besides a control group, there were three treatment groups which received a single injection of 200, 1,000, or 2,000 ng of SY into the air sac just before incubation. The eggs were opened on the 10th, 13th, 16th, and 21st days of incubation. Samples of the bursa of Fabricius, thymus, and spleen were taken from embryos. Serial sections of 5 μm thickness were stained with histological methods and routine histological procedures were performed.ResultsAn increase in the spleen volume was determined as the hatching time of the chicks approached. The highest eosinophil ratio was found in the SY1,000 and SY2,000 groups (P < 0.05), where the most significant change was developmental retardation in the thymus. In the bursa of Fabricius, there was less lymphocyte accumulation and eosinophilic cell infiltration with increasing doses.ConclusionIt was concluded that in ovo administered SY has undesired effects on embryonic development of the bursa of Fabricius, spleen, and thymus, and on spleen volume.

Aditivos alimentarios adicionados en alimentos envasados o enlatados en México ¿información confiable?

“…Se estima que tan solo en Estados Unidos más de 10000 productos químicos son agregados a los alimentos o tienen contacto en el envasado directa o indirectamente, de los cuales aproximadamente 1000 se utilizan bajo la denominación "Generalmente reconocido como seguro" 5 , sin embargo, no cuentan con la aprobación de la Administración de Drogas y Alimentos de los Estados Unidos (FDA). Aunque actualmente los AA son una parte fundamental de los alimentos, recientes investigaciones sugieren que potencialmente pueden ocasionar daños a la salud 6,7 . Esta situación contrapone la definición de seguridad alimentaria "todas las personas tienen, en todo momento, acceso físico, social y económico a alimentos suficientes, inocuos y nutritivos…" 8 .…”