Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice

Lee, Hee Jung; Jo, Suzy; Ryu, Jeonghyun; Jeong, Hyein; Lee, Guemsan; Ryu, Mi Heon; Jung, Myeong Ho; Kim, Hyungwoo; Kim, Byung Joo

doi:10.3892/mmr.2015.3618

Cited by 16 publications

(7 citation statements)

References 17 publications

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“…Topical application of the extract daily for six consecutive days led to the inhibition of ear thickness (30 or 300 μg on the left ear, p < 0.001; 30 μg on the right ear, p < 0.001), hyperplasia, spongiosis (100 μg/ear, p < 0.05 and 300 μg/ear, p < 0.001, respectively) and immune cell infiltration (100 μg/ear, p < 0.05; 300 μg/ear, p < 0.001) induced by DNFB. Moreover, the extract reduced the production of some pro-inflammatory mediators, such as IFN-γ (significant effect starting from 30 µg/ear), TNF-α (significant effect starting from 100 µg/ear), IL-6 (significant effect at 30 µg/ear), and MCP-1 (significant effect starting from 30 µg/ear) [ 80 ].…”

Section: Resultsmentioning

confidence: 99%

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A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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During the last 30 years, berries have gained great attention as functional food against several risk factors in chronic diseases. The number of related publications on Pubmed rose from 1000 items in 1990 to more than 11,000 in 2019. Despite the fact that a common and clear definition of “berries” is not shared among different scientific areas, the phytochemical pattern of these fruits is mainly characterized by anthocyanins, flavanols, flavonols, and tannins, which showed antioxidant and anti-inflammatory properties in humans. Skin insults, like wounds, UV rays, and excessive inflammatory responses, may lead to chronic dermatological disorders, conditions often characterized by long-term treatments. The application of berries for skin protection is sustained by long traditional use, but many observations still require a clear pharmacological validation. This review summarizes the scientific evidence, published on EMBASE, MEDLINE, and Scholar, to identify extraction methods, way of administration, dose, and mechanism of action of berries for potential dermatological treatments. Promising in vitro and in vivo evidence of Punica granatum L. and Vitis vinifera L. supports wound healing and photoprotection, while Schisandra chinensis (Turcz.) Baill. and Vaccinium spp. showed clear immunomodulatory effects. Oral or topical administrations of these berries justify the evaluation of new translational studies to validate their efficacy in humans.

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Section: Resultsmentioning

confidence: 99%

“…berries. Interestingly, S. chinensis berries polar extract has been assayed in a DNFB-induced dermatitis model with positive results after both topical or oral administration by Lee et al [ 80 ] and Jeon et al [ 79 ], respectively.…”

Section: Discussionmentioning

confidence: 99%

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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“…This plant has long been used for the treatment of night blindness, skin burn, aseptic inflammation, and liver diseases in traditional oriental medicine [23,24]. S. chinensis fruit extract and its lignan compounds have been shown to possess various pharmacological effects in murine cell lines.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, several studies using mouse models and human skin cell lines have revealed the therapeutic potential of S. chinensis for treating skin disorders. Lee et al reported that the methanol extract of S. chinensis fruit alleviated contact dermatitis symptoms by reducing the production of pro-inflammatory cytokines such as TNF-α and IFN-γ when topically applied [8,24]. Kang et al showed that Schisandra fructus water extract inhibited IκB activation, thereby suppressing the production of TNF-α, IL-6, and GM-CSF in the human mast cell line HMC-1 [26].…”

Section: Introductionmentioning

confidence: 99%

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes

Chae

Subedi

Jeong

et al. 2017

IJMS

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Gomisin N, one of the lignan compounds found in Schisandra chinensis has been shown to possess anti-oxidative, anti-tumorigenic, and anti-inflammatory activities in various studies. Here we report, for the first time, the anti-melenogenic efficacy of Gomisin N in mammalian cells as well as in zebrafish embryos. Gomisin N significantly reduced the melanin content without cellular toxicity. Although it was not capable of modulating the catalytic activity of mushroom tyrosinase in vitro, Gomisin N downregulated the expression levels of key proteins that function in melanogenesis. Gomisin N downregulated melanocortin 1 receptor (MC1R), adenylyl cyclase 2, microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2). In addition, Gomisin N-treated Melan-A cells exhibited increased p-Akt and p-ERK levels, which implies that the activation of the PI3K/Akt and MAPK/ERK pathways may function to inhibit melanogenesis. We also validated that Gomisin N reduced melanin production by repressing the expression of MITF, tyrosinase, TRP-1, and TRP-2 in mouse and human cells as well as in developing zebrafish embryos. Collectively, we conclude that Gomisin N inhibits melanin synthesis by repressing the expression of MITF and melanogenic enzymes, probably through modulating the PI3K/Akt and MAPK/ERK pathways.

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“…Both dexamethasone and MEBO showed similar anti-inflammatory efficacies in CD mice. However, dexamethasone significantly lowered the spleen/body weight ratio, which can be used as a hallmark of immune reaction,[ 25 26 27 ] compared to the normal group and the CTL group [ Figure 6b ]. In addition, average body weight gain was significantly lowered by treatment with dexamethasone [ Figure 6a ].…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of Brassica oleracea Var. capitata L. (Cabbage) methanol extract in mice with contact dermatitis

et al. 2018

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Background:Cabbage, Brassica oleracea var. capitata L., is one of the most common vegetables in the world. Because of its high levels of flavonoids and anthocyanins, cabbage has long been used as a herbal medicine. The antioxidant and anti-inflammatory properties of cabbage were also recently been reported.Objective:This study was designed to investigate the anti-inflammatory effects of cabbage in mice with contact dermatitis (CD).Materials and Methods:We investigated the effects of methanol extract of B. oleracea var. capitata L. (MEBO) on ear swelling, erythema, and histopathological changes in CD mice. Moreover, the effects on cytokine production and the spleen/body weight ratio were investigated.Results:Topical treatment with MEBO inhibited ear swelling and erythema significantly. MEBO also significantly inhibited epidermal hyperplasia and infiltration of immune cells. Furthermore, the levels of tumor necrosis factor-alpha, interferon-gamma, interleukin-6, and monocyte chemotactic protein-1 in inflamed tissues were effectively lowered by MEBO. Finally, MEBO did not affect body weight gain or spleen body weight ratio.Conclusions:These results indicate that cabbage can be used for the treatment of skin inflammation and that its anti-inflammatory activity is closely related to the inhibition of Th1 skewing reactions.SUMMARY MEBO inhibited ear thickness, weight, and erythema in inflamed skinMEBO also prevented epidermal hyperplasia and infiltration of immune cellsThe levels of tumor necrosis factor-α, interferon-γ, interleukin-6, and monocyte chemotactic protein-1 in inflamed tissues were lowered by MEBO. Abbreviations used: AOO: Acetone and olive oil (4:1), CBA: Cytometric bead array, CD: Contact dermatitis, DEX: Dexamethasone, DNFB: 1-fluoro-2,4-dinitrofluorobenzene, GM-CSF: Granulocyte-macrophage colony-stimulating factor, ICAM-1: Intercellular Adhesion Molecule-1, LPS: Lipopolysaccharide, MEBO: Methanol extract of Brassica oleracea, MCP-1: Monocyte chemotactic protein-1, NO: Nitric oxide.

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Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice

Cited by 16 publications

References 17 publications

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes

Anti-inflammatory effects of Brassica oleracea Var. capitata L. (Cabbage) methanol extract in mice with contact dermatitis

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